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RISS 인기검색어
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- 저자 : Cvjeticanin, Suzana (검색결과 2 건)
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Cvjeticanin, Suzana,Marinkovic, Dragoslav 한국유전학회 2005 Genes & Genomics Vol.27 No.1
Our study of genetic homozygosity degree includes an analysis of the presence, distribution and individual combination of 20 to 30 selected genetically controlled morpho-physiological traits in the four samples of patients from Belgrade affected with different diseases (OLD-congenital hip dislocation N = 93, DM-diabetes mellitus N = 95, TBC-tuberculosis N = 79, BC-bronchogen carcinoma N = 109). Taking into consideration our experience, as well as the experience of numerous scientists studying the nature of the inheritance of mono- and oligo-genetically controlled qualitative traits, we applied this methodology to estimate the proportion of such homozygously recessive characteristics (HRC-test). This population-genetic study did not only show statistically significant difference in the middle value of genetic homozygosity (CHD - 7.1±0.1, control - 5.2±0.1 ; DM - 6.3±0.3, control - 4.4±0.2 ; TBC - 6.1±0.3, BC - 5.9±0.3, control - 4.9±0.3), but also in the differences in the distribution type, as well as the differences in the presence of certain individual combinations of such traits. Further applications of HRC-testing may have practical use in genetic counselling, since homozygosity seems to be correlated with an individual's susceptibility to different diseases. The frequency of ABO blood types in the samples of patients with CUD, DM and BC were quite similar to the percentage of blood groups in the Serbian population. In the sample of TBC-affected patients, O blood group is almost significantly on the decrease, while the other blood groups are slightly on the increase, according to the average value of those blood groups in Serbian popoulation.
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