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Adhesion GPR123 is an indicator for recurrence and prognosis in bladder cancer
Liu Yaming,Wang Guodong,Cui Tongwei,Lv Lin 한국유전학회 2021 Genes & Genomics Vol.43 No.11
Background Bladder cancer is a common urinary cancer, and most patients sufer tumor recurrence after surgery. Identifying more prognostic biomarkers is an essential task for precious treatment. Objective To evaluate the expression and clinical signifcance of GPR123, Angiotensin-I a type of adhesion G proteincoupled receptors (aGPCRs), in bladder cancer. Methods The expressions of GPR123 in two retrospective cohorts comprised of 150 and 56 patients with bladder cancer respectively, were detected with and immunohistochemistry (IHC). Moreover, GPR123 mRNAs in 11 non-muscle-invasive bladder cancers (NMIBCs) and 11 muscle-invasive bladder cancers (MIBCs) were detected with qRT-PCR. The correlation between GPR123 and the clinicopathological characters was estimated by Chi-square test. The signifcance of GPR123 and other clinicopathological characters in recurrence and prognosis of bladder cancer was evaluated by univariate and multivariate analyses. Results GPR123 was mainly expressed in the cell membrane of bladder cancer. The percentages of high GPR123 expression in NMIBC and MIBC were 38.32 and 55.81% in cohort 1, and 16.00 and 43.90% in cohort 2. With qRT-PCR and IHC, we showed that GPR123 expression in MIBC was signifcantly higher than that in NMIBC. GPR123 was signifcantly associated with T and M stage of bladder cancer. GPR123 expression was all correlated with recurrence (disease-free survival rate), and prognosis (overall survival rate). High GPR123 expression was identifed as independent biomarker indicating easier recurrence and poorer prognosis. Conclusions GPR123 was an independent biomarker of bladder cancer for recurrence and prognosis, indicating that GPR123 detection with IHC after operation could help fnd the high-risk patients and direct the post-operational surveillance.