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RISS 인기검색어
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- 저자 : Cuffini, Cecilia Gabriela (검색결과 3 건)
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Mutation Detection of E6 and LCR Genes from HPV 16 Associated with Carcinogenesis
Mosmann, Jessica P.,Monetti, Marina S.,Frutos, Maria C.,Kiguen, Ana X.,Venezuela, Raul F.,Cuffini, Cecilia G. Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3
Human papillomavirus (HPV) is responsible for one of the most frequent sexually transmitted infections. The first phylogenetic analysis was based on a LCR region fragment. Nowadays, 4 variants are known: African (Af-1, Af-2), Asian-American (AA) and European (E). However the existence of sub-lineages of the European variant havs been proposed, specific mutations in the E6 and LCR sequences being possibly related to persistent viral infections. The aim of this study was a phylogenetic study of HPV16 sequences of endocervical samples from C${\acute{o}}$rdoba, in order to detect the circulating lineages and analyze the presence of mutations that could be correlated with malignant disease. The phylogenetic analysis determined that 86% of the samples belonged to the E variant, 7% to AF-1 and the remaining 7% to AF-2. The most frequent mutation in LCR sequences was G7521A, in 80% of the analyzed samples; it affects the binding site of a transcription factor that could contribute to carcinogenesis. In the E6 sequences, the most common mutation was T350G (L83V), detected in 67% of the samples, associated with increased risk of persistent infection. The high detection rate of the European lineage correlated with patterns of human migration. This study emphasizes the importance of recognizing circulating lineages, as well as the detection of mutations associated with high-grade neoplastic lesions that could be correlated to the development of carcinogenic lesions.
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Venezuela, Raul Fernando,Monetti, Marina Soledad,Kiguen, Ana Ximena,Frutos, Maria Celia,Mosmann, Jessica Paola,Cuffini, Cecilia Gabriela Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5
Background: Most studies of human papilloma virus (HPV) are aimed at the natural history of the infection and its relation to cancer; however, there are few studies to assess knowledge of the general population. Our aim was analyze the degree of knowledge of Argentinians about HPV infection and its prevention. Materials and Methods: We conducted a voluntary, anonymous and non-binding survey with 27 multiple-choice items, in twelve private and public establishments, selected to include a broad population in terms of education, age and gender. The survey consisted of three sections: individual characteristics of the volunteer, HPV infection basic knowledge, its prevention and the virus relationship with other cancers. Results: One thousand two hundred ninety seven volunteers aged 18 to 80 participated. The total number of correct answers was 45.1%. The correct answers for relationship HPV and cervical cancer was 62.1%. Almost 55% did not know about types of HPV that the vaccines for protection. Statistical analysis showed that women, single people, workers, the better educated, those who have had a STDs or HPV and receiving information through medical or educational establishments had greater knowledge of the topic. Only 0.2% of participants answered all questions correctly. Conclusions: Knowledge plays an important role in health care and the deficiency found in our population could influence the success of the measures taken in the fight against cervical cancer. In this regard, we believe it would be appropriate, not only to emphasize early diagnosis and vaccine implementation, but also incorporate new communication strategies, facilitating reception of accurate and precise information by all strata of society.
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Thiago Caon,Ricardo Augusto Konig,Ariadne Cristiane Cabral da Cruz,Simone Gonc¸alves Cardoso,Carlos Eduardo Maduro Campos,Silvia Lucia Cuffini,Letı´cia Scherer Koester,Cla´udia Maria Oliveira Simo˜es 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.9
Solid dispersions of saquinavir mesylate containingeither Gelucire 44/14 or poly(ethylene glycol)(PEG) 4000, or mixtures of each carrier with Tween 80 orpolyvinyl pyrrolidone (PVP) K30 were prepared in order toenhance the drug dissolution rate. These systems wereprepared by the melting method and characterized by X-raypowder diffraction, microscopical techniques, and Ramanspectroscopy aiming to establish a relationship betweenphysicochemical and dissolution properties under differentcooling conditions. Modifications in degree of crystallineorder/disorder over time were observed in preparationswith both carriers. Overall, formulations cooled and stored at -20 C showed less variation in dissolution rates thanthose at 25 C. Although Tween 80 has enhanced theknown self-emulsifying properties of Gelucire 44/14, itscombination with PEG 4000 displayed miscibility problems. The addition of PVP K30 was not the most effectiveapproach in enhancing the dissolution in early steps;however, the drug dissolution was stable after 7 days ofstorage at 25 C. The combination of PEG 4000 and PVPK30 maintained the dissolution properties for 60 and90 days at 25 C/95 % relative humidity and 40 C/75 %(f2 values[50), respectively.
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