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RISS 인기검색어
- 검색키워드
- 저자 : Csaba Toth (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Toth, Csaba,Kiss, Ferenc,Klarik, Zoltan,Gergely, Eszter,Toth, Eniko,Vanyolos, Katalin Peto Erzsebet,Miko, Iren,Nemeth, Norbert 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2
It is known that a moderate mechanical stress can even improve the red blood cells' (RBC) micro-rheological characteristics, however, a more significant stress causes deterioration in the deformability. In this study, we aimed to investigate the effect of the presence of artificial graft on the RBC deformability and membrane stability in beagles. In the Control group only anesthesia was induced and in the postoperative (p.o.) period blood samplings were carried out. In the Grafted group under general anesthesia, the left femoral artery was isolated, from which a 3.5 cm segment was resected and a PTFE graft (O.D.: 3 mm) of equal in length was implanted into the gap. On the $1^{st}$, $3^{rd}$, $5^{th}$, $7^{th}$ and 14th p.o. days blood was collected the cephalic veins and RBC deformability was determined ektacytometry (LoRRca MaxSis Osmoscan). Membrane stability test consisted of two deformability measurements before and after the cells were being exposed to mechanical stress (60 or 100 Pa for 300 seconds). Compared to the Control group and the baseline values the red blood cell deformability showed significant deterioration on the $3^{rd}$, $5^{th}$ and mainly on the $7^{th}$ postoperative day after the graft implantation. The membrane stability of erythrocyte revealed marked inter-group difference on the $3^{rd}$, $5^{th}$ and $7^{th}$ day: in the Grafted group the deformability decreased and during the membrane stability test smaller difference was observed between the states before and after shearing. We concluded that the presence of a PTFE graft in the femoral artery may cause changes in RBC deformability in the first p.o. week. RBC membrane stability investigation shows a lower elongation index profile for the grafted group and a narrowed alteration in the deformability curves due to mechanical stress.
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Csaba Toth,Ferenc Kiss,Zoltan Klarik,Eszter Gergely,Eniko Toth,Katalin Peto,Erzsebet Vanyolos,Iren Miko,Norbert Nemeth 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2
It is known that a moderate mechanical stress can even improve the red blood cells’ (RBC) micro-rheologicalcharacteristics, however, a more significant stress causes deterioration in the deformability. In thisstudy, we aimed to investigate the effect of the presence of artificial graft on the RBC deformability andmembrane stability in beagles. In the Control group only anesthesia was induced and in the postoperative(p.o.) period blood samplings were carried out. In the Grafted group under general anesthesia, the leftfemoral artery was isolated, from which a 3.5 cm segment was resected and a PTFE graft (O.D.: 3 mm)of equal in length was implanted into the gap. On the 1st, 3rd, 5th, 7th and 14th p.o. days blood was collectedthe cephalic veins and RBC deformability was determined ektacytometry (LoRRca MaxSis Osmoscan). Membrane stability test consisted of two deformability measurements before and after the cells werebeing exposed to mechanical stress (60 or 100 Pa for 300 seconds). Compared to the Control group andthe baseline values the red blood cell deformability showed significant deterioration on the 3rd, 5th andmainly on the 7th postoperative day after the graft implantation. The membrane stability of erythrocyterevealed marked inter-group difference on the 3rd, 5th and 7th day: in the Grafted group the deformabilitydecreased and during the membrane stability test smaller difference was observed between the statesbefore and after shearing. We concluded that the presence of a PTFE graft in the femoral artery maycause changes in RBC deformability in the first p.o. week. RBC membrane stability investigation showsa lower elongation index profile for the grafted group and a narrowed alteration in the deformabilitycurves due to mechanical stress.
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