http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Cong X. Wu (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
ZO-1 and -2 Are Required for TRPV1-Modulated Paracellular Permeability
Li, J.,Cong, X.,Zhang, Y.,Xiang, R.L.,Mei, M.,Yang, N.Y.,Su, Y.C.,Choi, S.,Park, K.,Zhang, L.W.,Wu, L.L.,Yu, G.Y. SAGE Publications 2015 Journal of dental research Vol.94 No.12
<P>The tight junction based paracellular pathway plays an important role in saliva secretion. Zonula occludens (ZO) proteins are submembranous proteins of tight junction complex; however, their function in salivary epithelium is poorly understood. Here, we found that activation of transient receptor potential vanilloid subtype 1 (TRPV I) by capsaicin increased rat saliva secretion both in vivo and ex vivo. Meanwhile, TRPV I activation enlarged the width of tight junctions between neighboring acinar cells, increased the paracellular flux of 4-kDa fluorescein isothiocyanate (FITC)-dextran in submandibular gland (SMG) tissues, and decreased transepithelial electric resistance (TER) in SMG-C6 cells. ZO-1, -2, and -3 were distributed principally to the apical lateral region of acinar cells in SMG tissues and continuously encircled the peripheries of SMG-C6 cells in the untreated condition. TRPV I activation obviously diminished ZO-1 and -2 staining, but not ZO-3 or f3-catenin, at the cell-cell contacts ex vivo and in vitro. Moreover, in untreated SMG-C6 cells, ZO-1 and -2 single or double knockdown by small interfering RNA (siRNA) increased the paracellular flux of 4-kDa FITC-dextran. In capsaicintreated cells, ZO-1 and -2 single or double knockdown abolished, whereas their re-expression restored, the capsaicin-induced increase in paracellular permeability. Furthermore, TRPV I activation increased RhoA activity, and inhibition of either RhoA or Rho kinase (ROCK) abolished the capsaicin-induced TER decrease as well as ZO-1 and -2 redistribution. These results indicate that ZO-1 and -2 play crucial roles in both basal salivary epithelial barrier function and TRPV I -modulated paracellular transport. RhoA-ROCK signaling pathway is responsible for TRPVI -modulated paracellular permeability as well as ZO-1 and -2 redistribution.</P>
-
A methodology for design of metallic dampers in retrofit of earthquake-damaged frame
Chao Zhang,Yun Zhou,De H. Lu,Cong X. Wu,Da G. Weng 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.56 No.4
A comprehensive methodology is proposed for design of metallic dampers in seismic retrofit of earthquake-damaged frame structures. It is assumed that the metallic dampers remain elastic and only provide stiffness during frequent earthquake (i.e., earthquake with a 63% probability of exceedance in 50- year service period), while in precautionary earthquake (i.e., earthquake with a 10% probability of exceedance in 50-year service period), the metallic dampers yield before the main frame and dissipate most of the seismic energy to either prevent or minimize structural damages. Therefore by converting multi-story frame to an equivalent single-degree-of-freedom system, the added stiffness provided by metallic dampers is designed to control elastic story drifts within code-based demand under frequent earthquake, and the added damping with the combination of added stiffness influences is obtained to control structural stress within performance-based target under precautionary earthquake. With the equivalent added damping ratio, the expected damping forces provided by metallic dampers can be calculated to carry out the configuration and design of metallic dampers along with supporting braces. Based on a detailed example for retrofit of an earthquake-damaged reinforced concrete frame by using metallic dampers, the proposed design procedure is demonstrated to be simple and practical, which can not only meet current China’s design codes but also be used in retrofit design of earthquake-damaged frame with metallic damper for reaching desirable performance objective.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
