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Yuqin Jiao,Chunsheng Xiao,Dengke Wu 한국항공우주학회 2022 International Journal of Aeronautical and Space Sc Vol.23 No.4
The research on both direct force measuring test technique of dynamic aerodynamic performance of oscillating airfoils in low-speed flow and inertial force and pitching moment correction technique is carried out in the two-dimensional test section of the NF-3 low-speed wind tunnel of Northwestern Polytechnical University. The influence of the inertial force and pitching moment of the airfoil model on wind tunnel experimental data of dynamic aerodynamic performance is studied, the signal interference of the experimental data is analyzed, and the digital filtering method of the data, and the correction method for inertial force and pitching moment of airfoil models are proposed. The analysis of the results shows that the experimental data have obvious interference signal components within frequency interval between 16 and 60 Hz. When the oscillation frequency of the airfoil increases, the frequency band of the interference component becomes wider. Low-pass digital filtering in which the lift and drag data are subjected to a cutoff frequency of 16 Hz and the pitching moment data to a cut-off frequency of 8 Hz can eliminate the signal interference. The direct force measuring result of dynamic aerodynamic performance in the wind-off state contains a certain amount of aerodynamic forces, and there is a larger error in the method in which the influence of inertial force and pitching moment on the direct force measuring result is corrected by subtracting the wind-off data in the dynamic test. It is correct and feasible to use designed model motion law to fit the change of the angle of attack, to calculate and correct the inertial force and pitching moment. As the reduced frequency increases, the dynamic stall of the pitching oscillating airfoil is further delayed and the hysteresis loop of lift and pitching moment becomes larger.
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pH-Responsive Drug Delivery Systems Based on Clickable Poly(L-glutamic acid)-Grafted Comb Copolymers
Jianxun Ding,Xuesi Chen,Chaoliang He,Chunsheng Xiao,Jie Chen,Xiuli Zhuang 한국고분자학회 2012 Macromolecular Research Vol.20 No.3
Five pH-responsive alkyne-poly(2-aminoethyl methacrylate)-graft-poly(L-glutamic acid) (alkyne-PAMA-g-PLGA) comb copolymers were synthesized through the ring-opening polymerization (ROP) of γ-benzyl-L-glutamate N-carboxyanhydride (BLG NCA) and the subsequent deprotection of benzyl group from BLG unit. The chemical structures of copolymers were confirmed by proton nuclear magnetic resonance spectra (1H NMR) and Fourier transform infrared spectroscopy (FTIR). The pyrene-probe-based fluorescence technique and transmission electron microscopy (TEM) measurements revealed that the comb copolymers could spontaneously self-assemble into micellar or vesicular nanoparticles in phosphate buffered saline (PBS) at pH 7.4. Doxorubicin (DOX), an anthracycline anticancer drug, was loaded into nanoparticles as a model anticancer drug. The in vitro release results showed that the release behaviors could be altered by adjusting the composition of the comb copolymer and pH of the release medium. In vitro methyl thiazolyl tetrazolium (MTT) assays demonstrated that the copolymers were biocompatible,and DOX-loaded nanoparticles showed effective inhibition of cellular proliferation. Hemolysis tests indicated that the copolymers were also hemocompatible, and that the presence of the copolymers could reduce the hemolysis ratio (HR) of the DOX significantly. In addition, the comb copolymers could be modified through versatile Cu(I)-catalyzed “click chemistry” between the terminal alkyne group and azide-modified functional agents. These properties indicate that the pH-responsive clickable comb copolymers are promising candidates for multifunctional nanocarriers in cancer diagnosis and therapy.
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