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- 저자 : Chun-Shian Tsai (검색결과 2 건)
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Chun-Shian Tsai,Kun-Shien Tsai,Ming-Tsai Hsu 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10
Today’s automobile is featuring a large number of Electronic Control Units (ECUs). This will increase the system complexity, which will consequently increase the difficulties of programming design and safety and the software cost. Therefore, it is important to provide a reliable, real-time, effective and eventually a low-cost software development tool in the automotive industrial market. ERIKA Enterprise provides an open source for multi-processor real-time operating system kernel, implementing a collection of application programming interfaces similar to those of OSEK/VDX standard for automotive embedded controllers. In this paper, we research the automotive software framework for ERIKA Enterprise, and through the conducting of ERIKA software, the real time operating system for OSEK can be ported (embedded) into target ECU hardware in easily. Finally, we propose a demonstrative application for enhanced CAN (ECAN) bus network connection to show how real-time transmission of data frames through ECAN bus network connection is guaranteed by ERIKA Enterprise.
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Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target
Ming-Shian Tsai,Po-Huang Lee,Cheuk-Kwan Sun,Ting-Chia Chiu,Yu-Chun Lin,I-Wei Chang,Po-Han Chen,Ying-Hsien Kao 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in human livers with hepatolithiasis and the effects of NGF therapy on liver injury and hepatic SIRT1 expression in a bile duct ligation (BDL) mouse model. Histopathological and molecular analyses showed that the hepatocytes of human diseased livers expressed NGF, proNGF (a precursor of NGF), TrkA and p75NTR, whereas only p75NTR was upregulated in hepatolithiasis, compared with non-hepatolithiasis livers. In the BDL model without NGF therapy, p75NTR, but not TrkA antagonism, significantly deteriorated BDL-induced liver injury. By contrast, the hepatoprotective effect of NGF was abrogated only by TrkA and not by p75NTR antagonism in animals receiving NGF therapy. Intriguingly, a positive correlation between hepatic SIRT1 and NGF expression was found in human livers. In vitro studies demonstrated that NGF upregulated SIRT1 expression in mouse livers and human Huh-7 and rodent hepatocytes. Both NGF and proNGF induced protective effects against hydrogen peroxide-induced cytotoxicity in Huh-7 cells, whereas inhibition of TrkA and p75NTR activity prevented oxidative cell death. Mechanistically, NGF, but not proNGF, upregulated SIRT1 expression in human Huh-7 and rodent hepatocytes via nuclear factor (NF)-κB activity, whereas NGF-induced phosphoinositide-3 kinase/Akt, extracellular signal–regulated kinase and NF-κB signaling and SIRT1 activity were involved in its hepatoprotective effects against oxidative injury. These findings suggest that pharmacological manipulation of the NGF/SIRT1 axis might serve as a novel approach for the treatment of cholestatic disease.
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