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Excler, Jean-Louis,Delvecchio, Christopher J.,Wiley, Ryan E.,Williams, Marni,Yoon, In-Kyu,Modjarrad, Kayvon,Boujelal, Mohamed,Moorthy, Vasee S.,Hersi, Ahmad Salah,Kim, Jerome H. U.S. Department of Health and Human Services * Cen 2016 Emerging Infectious Diseases Vol.22 No.8
<P>Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, Saudi Arabia, on November 14–15, 2015, to discuss vaccine development challenges. The meeting was spearheaded by the Saudi Ministry of Health and co-organized by the International Vaccine Institute, South Korea. Accelerating the development of a preventive vaccine requires a better understanding of MERS epidemiology, transmission, and pathogenesis in humans and animals. A combination of rodent and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic vaccine candidates. Dromedary camels should be considered for the development of veterinary vaccines. Several vaccine technology platforms targeting the MERS-CoV spike protein were discussed. Mechanisms to maximize investment, provide robust data, and affect public health are urgently needed.</P>
Choi, Kyung Min,Kim, Dohyung,Rungtaweevoranit, Bunyarat,Trickett, Christopher A.,Barmanbek, Jesika Trese Deniz,Alshammari, Ahmad S.,Yang, Peidong,Yaghi, Omar M. American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.1
<P>Materials development for artificial photosynthesis, in particular, CO2 reduction, has been under extensive efforts, ranging from inorganic semiconductors to molecular complexes. In this report, we demonstrate a metal organic framework (MOF)-coated nanoparticle photocatalyst with enhanced CO2 reduction activity and stability, which stems from having two different functional units for activity enhancement and catalytic stability combined together as a single construct. Covalently attaching a CO2-to-CO conversion photocatalyst Re-I(CO)(3)(BPYDC)Cl, BPYDC = 2,2'-bipyridine-5,5'-dicarboxylate, to a zirconium MOF, UiO-67 (Re-n-MOF), prevents dimerization leading to deactivation. By systematically controlling its density in the framework (n = 0, 1, 2, 3, 5, 11, 16, and 24 complexes per unit cell), the highest photocatalytic activity was found for Re-3-MOF. Structural analysis of Re-MOFs suggests that a fine balance of proximity between photoactive centers is needed for cooperatively enhanced photocatalytic activity, where an optimum number of Re complexes per unit cell should reach the highest activity. Based on the structure-activity correlation of Ren-M0Fs, Rea-MOF was coated onto Ag nanocubes (AgCRe3-MOF), which spatially confined photoactive Re centers to the intensified near-surface electric fields at the surface of Ag nanocubes, resulting in a 7-fold enhancement of CO2-to-CO conversion under visible light with long-term stability maintained up to 48 h.</P>