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        Pursuing prosthetic electronic skin

        Chortos, Alex,Liu, Jia,Bao, Zhenan Nature Publishing Group, a division of Macmillan P 2016 NATURE MATERIALS Vol.15 No.9

        Skin plays an important role in mediating our interactions with the world. Recreating the properties of skin using electronic devices could have profound implications for prosthetics and medicine. The pursuit of artificial skin has inspired innovations in materials to imitate skin's unique characteristics, including mechanical durability and stretchability, biodegradability, and the ability to measure a diversity of complex sensations over large areas. New materials and fabrication strategies are being developed to make mechanically compliant and multifunctional skin-like electronics, and improve brain/machine interfaces that enable transmission of the skin's signals into the body. This Review will cover materials and devices designed for mimicking the skin's ability to sense and generate biomimetic signals.

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        A bioinspired flexible organic artificial afferent nerve

        Kim, Yeongin,Chortos, Alex,Xu, Wentao,Liu, Yuxin,Oh, Jin Young,Son, Donghee,Kang, Jiheong,Foudeh, Amir M.,Zhu, Chenxin,Lee, Yeongjun,Niu, Simiao,Liu, Jia,Pfattner, Raphael,Bao, Zhenan,Lee, Tae-Woo American Association for the Advancement of Scienc 2018 Science Vol.360 No.6392

        <P>The distributed network of receptors, neurons, and synapses in the somatosensory system efficiently processes complex tactile information. We used flexible organic electronics to mimic the functions of a sensory nerve. Our artificial afferent nerve collects pressure information (1 to 80 kilopascals) from clusters of pressure sensors, converts the pressure information into action potentials (0 to 100 hertz) by using ring oscillators, and integrates the action potentials from multiple ring oscillators with a synaptic transistor. Biomimetic hierarchical structures can detect movement of an object, combine simultaneous pressure inputs, and distinguish braille characters. Furthermore, we connected our artificial afferent nerve to motor nerves to construct a hybrid bioelectronic reflex arc to actuate muscles. Our system has potential applications in neurorobotics and neuroprosthetics.</P>

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        A skin-inspired organic digital mechanoreceptor

        Tee, Benjamin C.-K.,Chortos, Alex,Berndt, Andre,Nguyen, Amanda Kim,Tom, Ariane,McGuire, Allister,Lin, Ziliang Carter,Tien, Kevin,Bae, Won-Gyu,Wang, Huiliang,Mei, Ping,Chou, Ho-Hsiu,Cui, Bianxiao,Deiss American Association for the Advancement of Scienc 2015 Science Vol.350 No.6258

        <P><B>Sensing the force digitally</B></P><P>Our skin provides us with a flexible waterproof barrier, but it also contains a sensor array that feels the world around us. This array provides feedback and helps us to avoid a hot object or increase the strength of our grip on an object that may be slipping away. Tee <I>et al.</I> describe an approach to simulate the mechanoreceptors of human skin, using pressure-sensitive foils and printed ring oscillators (see the Perspective by Anikeeva and Koppes). The sensor successfully converted pressure into a digital response in a pressure range comparable to that found in a human grip.</P><P><I>Science</I>, this issue p. 313; see also p. 274</P><P>Human skin relies on cutaneous receptors that output digital signals for tactile sensing in which the intensity of stimulation is converted to a series of voltage pulses. We present a power-efficient skin-inspired mechanoreceptor with a flexible organic transistor circuit that transduces pressure into digital frequency signals directly. The output frequency ranges between 0 and 200 hertz, with a sublinear response to increasing force stimuli that mimics slow-adapting skin mechanoreceptors. The output of the sensors was further used to stimulate optogenetically engineered mouse somatosensory neurons of mouse cortex in vitro, achieving stimulated pulses in accordance with pressure levels. This work represents a step toward the design and use of large-area organic electronic skins with neural-integrated touch feedback for replacement limbs.</P>

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