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Disruption of TACE-filamin interaction can inhibit TACE-mediated ectodomain shedding
Cho, Yongcheol,Park, Dongeun,Kim, Chungho Elsevier 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Ectodomain shedding regulates functions of many membrane proteins through the cleavage of their juxtamembrane region mainly by a disintegrin and metalloproteinase family proteinases. Tumor necrosis factor-alpha converting enzyme (TACE) is known to be responsible for phorbol myristate acetate (PMA)-induced shedding of various membrane proteins. How PMA regulates TACE-dependent shedding and how TACE exhibits substrate specificity without proteolysis of other membrane proteins are questionable. Here, we show that TACE can interact with an actin-binding protein, filamin, through 20th filamin repeat. We found that the interaction between TACE and filamin was increased by PMA treatment. In addition, loss of filamin or specific disruption of TACE-filamin interaction inhibited ectodomain shedding of representative TACE substrates, CD44 and amyloid protein precursor. From these data, we suggest that filamin may work as a scaffold that can recruit TACE and its substrates in a PMA-dependent manner to achieve substrate specificity for TACE.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Upon PMA stimulation, filamin interacts with TACE through its 20th filamin repeat. </LI> <LI> Disruption of the interaction inhibits PMA-induced shedding of CD44 and APP. </LI> <LI> Filamin may work as a scaffold that can recruit TACE and its substrates. </LI> </UL> </P>
Cho, Yongcheol,Di Liberto, Valentina,Carlin, Dan,Abe, Namiko,Li, Kathy H.,Burlingame, Alma L.,Guan, Shenheng,Michaelevski, Izhak,Cavalli, Valeria American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.22
<P>Injured peripheral neurons successfully activate intrinsic signaling pathways to enable axon regeneration. We have previously shown that dorsal root ganglia (DRG) neurons activate the mammalian target of rapamycin (mTOR) pathway following injury and that this activity enhances their axon growth capacity. mTOR plays a critical role in protein synthesis, but the mTOR-dependent proteins enhancing the regenerative capacity of DRG neurons remain unknown. To identify proteins whose expression is regulated by injury in an mTOR-dependent manner, we analyzed the protein composition of DRGs from mice in which we genetically activated mTOR and from mice with or without a prior nerve injury. Quantitative label-free mass spectrometry analyses revealed that the injury effects were correlated with mTOR activation. We identified a member of the soluble <I>N</I>-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family of proteins, syntaxin13, whose expression was increased by injury in an mTOR-dependent manner. Increased syntaxin13 levels in injured nerves resulted from local protein synthesis and not axonal transport. Finally, knockdown of syntaxin13 in cultured DRG neurons prevented axon growth and regeneration. Together, these data suggest that syntaxin13 translation is regulated by mTOR in injured neurons to promote axon regeneration.</P>
조용철(Cho, Yongcheol) 역사학회 2017 역사학보 Vol.0 No.233
Since its foundation, the Joseon Dynasty maintained friendly relations with some of Jurchen due to their support of the Joseon founder, King Taejo. For this reason, the Joseon could expand the territory in northeast area. However, when King Taejo laid down the scepter and his son King Taejong ascended the throne, some of the Jurchen became agitated and participated in Josaui’s rebellion(1402). Meanwhile, the Ming Dynasty actively promoted a policy of assimilation for the Jurchen. In response to this phenomenon, some of Jurchen intented to resist influence of the Joseon. In the 10th year of King Taejong’s reign(1410), the Udike invaded to the northeast of the Joseon territory. This meant that the influence of the founder King Taejo, who died in the 8th year of King Taejong’s reign(1408), had worn off. In response, King Taejong chose to attack the Jurchen to make new relations. But, the territory in the northeast suffered. Eventually, the Joseon had to retreat back behind the northeast border. However, by the reign of Sejong who succeeded Taejong, all negative attitudes of the incident had disappeared internally and positive aspects were emphasized. In result, the Joseon started to assert their right to northeast area again. It’s one of the Sejong’s policy to make holy their ancestors.
Enhanced Photosensitivity in Monolayer MoS<sub>2</sub> with PbS Quantum Dots
Cho, Sangeun,Jo, Yongcheol,Woo, Hyeonseok,Kim, Jongmin,Kwak, Jungwon,Kim, Hyungsang,Im, Hyunsik The Korean Vacuum Society 2017 Applied Science and Convergence Technology Vol.26 No.3
Photocurrent enhancement has been investigated in monolayer (1L) $MoS_2$ with PbS quantum dots (QDs). A metal-semiconductor-metal (Au-1L $MoS_2$-Au) junction device is fabricated using a standard photolithography method. Considerably improved photo-electrical properties are obtained by coating PbS QDs on the Au-1L $MoS_2$-Au device. Time dependent photoconductivity and current-voltage characteristics are investigated. For the QDs-coated $MoS_2$ device, it is observed that the photocurrent is considerably enhanced and the decay life time becomes longer. We propose that carriers in QDs are excited and transferred to the $MoS_2$ channel under light illumination, improving the photocurrent of the 1L $MoS_2$ channel. Our experimental findings suggest that two-dimensional layered semiconductor materials combined with QDs could be used as building blocks for highly-sensitive optoelectronic detectors including radiation sensors.
Cho, Sangeun,Lee, Seongwoo,Hou, Bo,Kim, Jongmin,Jo, Yongcheol,Woo, Hyeonseok,Pawar, Sambhaji M.,Inamdar, Akbar I.,Park, Youngsin,Cha, SeungNam,Kim, Hyungsang,Im, Hyunsik Pergamon Press 2018 Electrochimica Acta Vol. No.
<P><B>Abstract</B></P> <P>Mesoporous Ni-Co oxide (NCO) nanosheet electrodes are fabricated on Ni foam via an electrodeposition technique. Their bifunctional activities for electrochemical energy storage and electro-catalysis for water splitting in strong alkaline media are optimized by varying the ratio of concentrations of the Ni and Co precursors. The ratio-based changes vary the pore size of the NCO nanosheets between 92.5 and 200 nm, and structural analyses reveal that the electrode films have a spinel NiCo<SUB>2</SUB>O<SUB>4</SUB> structure. The obtained specific capacitance varies dramatically between 613 and 2704 Fg<SUP>−1</SUP> at 2 mA cm<SUP>−2</SUP>, with good capacity retention (80–90%) after 2000 cycles. The NCO nanosheet electrodes also exhibit a good oxygen evolution reaction at the surface. The lowest overpotential (315 mV at 10 mA cm<SUP>−2</SUP>) is obtained with a Tafel slope of 59 mV dec<SUP>−1</SUP>. The observed bifunctional activities of the new NCO nanosheet electrode are superior to those of nanostructured NCO electrodes prepared via hydrothermal and SILAR methods. The analyses regarding the electrochemically active surface area and electrochemical impedance spectroscopy, together with the observed electrochemical performance, reveal that the most-optimized Ni and Co composition produces the synergetic effects of an electrochemically active surface area and great stability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mesoporous Ni-Co oxide (NCO) nanosheet electrodes are fabricated on Ni foam via an electrodeposition technique. </LI> <LI> Excellent specific capacitance and electrochemical stability are obtained. </LI> <LI> The overpotential of 315 mV at 10 mA cm<SUP>−2</SUP> is obtained with a Tafel slope of 59 mV dec<SUP>−1</SUP>. </LI> </UL> </P>
Cho, Sangeun,Kim, Jongmin,Jo, Yongcheol,Ahmed, Abu Talha Aqueel,Chavan, H.S.,Woo, Hyeonseok,Inamdar, A.I.,Gunjakar, J.L.,Pawar, S.M.,Park, Youngsin,Kim, Hyungsang,Im, Hyunsik ELSEVIER SCIENCE 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.725 No.-
<P><B>Abstract</B></P> <P>Ruthenium oxide (RuO<SUB>2</SUB>) is fabricated on graphene (Gr)-coated Copper (Cu) foil by using a cathodic electroplating technique for flexible supercapacitor electrode applications. The electrochemical properties of the RuO<SUB>2</SUB>/Gr/Cu electrode are investigated with a conventional three electrode configuration in 0.5 M H<SUB>2</SUB>SO<SUB>4</SUB> electrolyte. The graphene insertion layer plays a key role in improving the structural and electrochemical properties of the RuO<SUB>2</SUB> electrode film under the bent condition. The electrode exhibits a specific capacitance of 1561 F g<SUP>−1</SUP> (0.015 F cm<SUP>−1</SUP>) at a scan rate of 5 mV s<SUP>−1</SUP> and a significantly improved retention of 98% under the bent condition. The flexible RuO<SUB>2</SUB>/Gr/Cu electrode exhibits a high energy density of ∼13 Wh kg<SUP>−1</SUP> at a power density of ∼21 kW kg<SUP>−1</SUP>. The excellent capacitance retention and electrochemical stability of the flexible RuO<SUB>2</SUB>/Gr/Cu electrode are due to the improved mechanical adhesion between the RuO<SUB>2</SUB> and the current collector. This flexible RuO<SUB>2</SUB>/Gr/Cu film could be used as a supercapacitor electrode with a high capacity and long-cycle life for the next-generation flexible electronic applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A binder-free Bendable RuO<SUB>2</SUB> thin film is fabricated on a graphene/Cu substrate using an electroplating method. </LI> <LI> Electrochemical energy storage properties of RuO<SUB>2</SUB> are investigated for supercapacitor applications. </LI> <LI> Excellent capacitance retention and electrochemical stability are obtained. </LI> </UL> </P>