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Harshal Pawar,Chhaya Varkhade,Pravin Jadhav,Kavita Mehra 한국한의학연구원 2014 Integrative Medicine Research Vol.3 No.2
Background: Orodispersible tablets or fast dissolving tablets dissolve or disintegrate imme-diately on the patients’ tongue or buccal mucosa. This drug delivery system is suitable fordrugs undergoing high first pass metabolism. It improves bioavailability, reduces dosingfrequency, and thereby minimizes the side effects and also makes the dosage form morecost-effective. In this study, polysaccharide isolated from the seeds of Cassia tora was inves-tigated as a superdisintegrant in the orodispersible tablets. The model drug chosen wasvalsartan, an antihypertensive drug.Methods: Valsartan tablets were prepared separately using different concentrations (1%, 2.5%,5%, and 7.5% w/w) of isolated C. tora seed polysaccharide (natural) and sodium starch glyco-late (synthetic) as superdisintegrant by the direct compression method. Evaluation of tabletswas done for various pre- and postcompression parameters. The stability studies were per-formed on optimized formulation F4. The disintegration time and in vitro drug release of theformulation F4 were compared with marketed formulations (conventional tablets).Results: The drug excipient interactions were characterized by Fourier transform infraredstudies. The formulation F4 containing 7.5% polysaccharide showed good wetting timeand disintegration time as compared to a formulation prepared using a synthetic super-disintegrant at the same concentration level. Hence, batch F4 was considered optimizedformulation.Conclusion: The present work revealed that C. tora seed polysaccharide has a good potentialas a disintegrant in the formulation of orodispersible tablets. Because C. tora polysaccharideis inexpensive as compared to synthetic superdisintegrants, nontoxic, compatible, and easyto manufacture, it can be used in place of currently marketed superdisintegrants.