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Cheon Jae Hee,Kim Hyun-Soo,Han Dong Soo,Kim Sung Kook,Shin Sung Jae,Kim Joo Sung,Ye Byong Duk,Song Geun Am,Lee YoungJa,Kim Youngdoe,Lee Yoosun,Kim Won Ho 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.5
Background/Aims: To date, there is no prospective study that specifically investigated the efficacy of infliximab in intestinal Behçet’s disease (BD). This study evaluated the efficacy of infliximab in patients with moderate-to-severe active intestinal BD that are refractory to conventional therapies. Methods: This phase 3, interventional, open-label, single-arm study evaluated clinical outcomes of infliximab treatment in patients with moderate-to-severe intestinal BD. The coprimary endpoints were clinical response, decrease in disease activity index for intestinal BD (DAIBD) score ≥20 from weeks 0 to 8 for the induction therapy and week 32 for the maintenance therapy. Results: A total of 33 patients entered the induction therapy and were treated with infliximab 5 mg/kg intravenously at weeks 0, 2, and 6. The mean DAIBD score changed from 90.8±40.1 at week 0 to 40.3±36.4 at week 8, with a significant mean change of 50.5±36.4 (95% confidence interval, 37.5 to 63.4; p<0.001). Thirty-one (93.9%) continued to receive 5 mg/kg infliximab every 8 weeks during the maintenance therapy. The mean change in the DAIBD score after the maintenance therapy was statistically significant (61.5±38.5; 95% confidence interval, 46.0 to 77.1; p<0.001, from weeks 0 to 32). The proportion of patients who maintained a clinical response was 92.3% at week 32. No severe adverse reactions occurred during the induction and maintenance therapies. Conclusions: This study provided evidence that infliximab 5 mg/kg induction and maintenance therapies are efficacious and well-tolerated in patients with moderate-to-severe active intestinal BD. (ClinicalTrials.gov identifier: NCT02505568)
Cheon, Jae Hee,Kim, Jae Hak,Kim, Bo Young,Kim, Seung Won,Hong, Sung Yi,Eun, Chang Soo,Hong, Seong Soo,Byeon, Jeong-Sik,Kim, Tae Il,Han, Dong Soo,Yang, Suk-Kyun,Lee, Kyoung Ryul,Kim, Won Ho G. Thieme 2009 Hepato-gastroenterology Vol.56 No.90
<P>BACKGROUND/AIMS: Adverse reactions to thiopurines may be predisposed by thiopurine methyltransferase (TPMT) or inosine triphosphate pyrophosphatase (ITPA) gene mutations. METHODOLOGY: We examined the frequencies of TPMT and ITPA gene polymorphisms in 812 Korean patients with inflammatory bowel diseases using denaturing high performance liquid chromatography and direct sequencing. Results: The allele frequencies of TPMT*2, TPMT*3A, TPMT*3B, and TPMT*3C were 0, 0, 0, and 0.010 (17/1624), respectively. For the ITPA polymorphism, 173 subjects were heterozygous and 5 were homozygous for the 94C>A missense mutation (allele frequency of A, 0.113). Moreover, the 87T>C, IVS2+21A>C, and IVS2+53C>T polymorphisms were found in one patient each (1/1624), respectively. Of these, 87T>C and IVS2+53C>T were novel single nucleotide polymorphisms of the ITPA gene whose clinical significance should be further evaluated. CONCLUSIONS: Our data describe TPMT and ITPA gene mutation patterns among Koreans and provide a basis for screening studies to identify patients at high risk for myelotoxicity from thiopurine drugs.</P>
Han, Jae Yun,Park, Sun Hee,Yang, Ji Hye,Kim, Mi Gwang,Cho, Seung Sik,Yoon, Goo,Cheon, Seung Hoon,Ki, Sung Hwan Korean Society of ToxicologyKorea Environmental Mu 2014 Toxicological Research Vol.30 No.1
Licochalcone (LC), a major phenolic retrochalcone from licorice, has anti-inflammatory activity. This study investigated the effects of licochalcone A (LCA) and licochalcone E (LCE) on Liver X receptor-${\alpha}$ ($LXR{\alpha}$)-mediated lipogenic gene expression and the molecular mechanisms underlying those effects. LCA and LCE antagonized the ability of $LXR{\alpha}$ agonists (T0901317 or GW3965) to increase sterol regulatory element binding protein-1c (SREBP-1c) expression and thereby inhibited target gene expression (e.g., FAS and ACC) in HepG2 cells. Moreover, treatment with LCA and LCE impaired $LXR{\alpha}/RXR{\alpha}$-induced CYP7A1-LXRE-luciferase (CYP7A1) transactivation. The AMPK-Sirt1 signaling pathway is an important regulator of energy metabolism and, therefore, a potential therapeutic target for metabolic diseases, including hepatic steatosis. We found here that LCE increased AMPK phosphorylation and Sirt1 expression. We conclude that LC inhibits SREBP-1c-mediated hepatic lipogenesis via activation of the AMPK/Sirt1 signaling pathway.
Royal jelly reduces melanin synthesis through down-regulation of tyrosinase expression.
Han, Sang Mi,Yeo, Joo Hong,Cho, Yoon Hee,Pak, Sok Cheon Institute for Advanced Research in Asian Science a 2011 The American journal of Chinese medicine Vol.39 No.6
<P>For cosmetic reasons, the demand for effective and safe skin-whitening agents is high. Since the key enzyme in the melanin synthetic pathway is tyrosinase, many depigmenting agents in the treatment of hyperpigmentation act as tyrosinase inhibitors. In this study, we have investigated the hypo-pigmentary mechanism of royal jelly in a mouse melanocyte cell line, B16F1. Treatment of B16F1 cells with royal jelly markedly inhibited melanin biosynthesis in a dose-dependent manner. Decreased melanin content occurred through the decrease of tyrosinase activity. The mRNA levels of tyrosinase were also reduced by royal jelly. These results suggest that royal jelly reduces melanin synthesis by down-regulation of tyrosinase mRNA transcription and serves as a new candidate in the design of new skin-whitening or therapeutic agents.</P>
Chiral solitons in a coupled double Peierls chain
Cheon, Sangmo,Kim, Tae-Hwan,Lee, Sung-Hoon,Yeom, Han Woong American Association for the Advancement of Scienc 2015 Science Vol.350 No.6257
<P><B>Handedness at the edge of a line</B></P><P>Topological insulators are characterized by conducting boundary states. For those existing as two-dimensional (2D) materials, the boundaries are lines, the edge currents are 1D, and their two spin components flow in opposite directions. To address whether this handedness also applies to the edge states of 1D topological systems, Cheon <I>et al.</I> deposited indium atoms on the surface of silicon, where the atoms formed wires consisting of double zigzag chains. The chains underwent distortions that caused topological edge states called solitons to appear under certain conditions. The solitons came in three flavors, two of which had a definite handedness.</P><P><I>Science</I>, this issue p. 182</P><P>Chiral edge states are the hallmark of two- and three-dimensional topological materials, but their one-dimensional (1D) analog has not yet been found. We report that the 1D topological edge states, solitons, of the charge density wave system of indium atomic wires self-assembled on a silicon surface have chirality. The system is described by a coupled double Peierls-dimerized atomic chain, where the interchain coupling induces dynamical sublattice symmetry breaking. This changes its topological symmetry from [Formula] to [Formula] and endows solitons with a chiral degree of freedom. Chiral solitons can produce quantized charge transport across the chain that is topologically protected and controllable by the soliton’s chirality. Individual right- and left-chiral solitons in indium wires are directly identified by scanning tunneling microscopy.</P>