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Zhe Chen,Junqing Zhu,Jiantao Peng,Xingxiang Zhang,Jianyue Ren 한국광학회 2016 Current Optics and Photonics Vol.20 No.1
A novel optical design for high resolution, large field of view (FOV) and multispectral remote sensingis presented. An f/7.3 Korsch and two f/17.9 Cook three-mirror optical systems are integrated by sharingthe primary and secondary mirrors, bias of the FOV, decentering of the apertures and reasonable structurearrangement. The aperture stop of the Korsch system is located on the primary mirror, while those ofthe Cook systems are on the exit pupils. High resolution image with spectral coverage from visible tonear-infrared (NIR) can be acquired through the Korsch system with a focal length of 14 m, whilewide-field imaging is accomplished by the two Cook systems whose focal lengths are both 13.24 m. The full FOV is 4°×0.13°, a coverage width of 34.9 km at the altitude of 500 km can then be acquiredby push-broom imaging. To facilitate controlling the stray light, the intermediate images and the real exitpupils are spatially available. After optimization, a near diffraction-limited performance and a compactoptical package are achieved. The sharing of the on-axis primary and secondary mirrors reduces the costof fabrication, test, and manufacture effectively. Besides, the two tertiary mirrors of the Cook systemspossess the same parameters, further cutting down the cost.
Shuai Yang,Wei Sha,Changzheng Chen,Xingxiang Zhang,Jianyue Ren 한국광학회 2016 Current Optics and Photonics Vol.20 No.3
A Carbon Fiber Composite (CFC) framework was designed for a small lightweight space camera. According to the distribution characteristics of each optical element in the optical system, CFC (M40J)was chosen to accomplish the design of the framework. TC4 embedded parts were used to solve the lowaccuracy of the CFC framework interface problem. An integrated optimization method and the optimizationstrategy which combined a genetic global optimization algorithm with a downhill simplex local optimizationalgorithm were adopted to optimize the structure parameters of the framework. After optimization, thetotal weight of the CFC framework and the TC4 embedded parts is 15.6 kg, accounting for only 18.4%that of the camera. The first order frequency of the camera reaches 104.8 Hz. Finally, a mechanicalenvironment test was performed, and the result demonstrates that the first order frequency of the camerais 102 Hz, which is consistent with the simulation result. It further verifies the rationality and correctnessof the optimization result. The integrated optimization method mentioned in this paper can be applied tothe structure design of other space cameras, which can greatly improve the structure design efficiency.
Integrated Modeling for the Design of Deformable Mirrors Using a Parametric Module Method
Junqing Zhu,Wei Sha,Changzheng Chen,Xingxiang Zhang,Jianyue Ren 한국광학회 2015 Current Optics and Photonics Vol.19 No.5
Active optics is a key technology for future large-aperture space telescopes. In the design of deformablemirrors for space applications, the design parameter trade-off between the number of regularly configuredactuators and the correction capability is essential but rarely analyzed, due to the lack of design legacy. This paper presents a parametric module method for integrated modeling of deformable mirrors withregularly configured actuators. A full design parameter space is explored to evaluate the correctioncapability and the mass of deformable mirrors, using an autoconstructed finite-element parametric modelingmethod that utilizes manual finite-element meshing for complex structures. These results are used to providedesign guidelines for deformable mirrors. The integrated modeling method presented here can be used forfuture applied optics projects
NEDD4L suppresses PD-L1 expression and enhances anti-tumor immune response in A549 cells
Zhong Bin,Zheng Jie,Wen Huilan,Liao Xinhui,Chen Xingxiang,Rao Yunwei,Yuan Ping 한국유전학회 2022 Genes & Genomics Vol.44 No.9
Background: Non-small cell lung cancer (NSCLC) poses a salient threat to public health. E3 ubiquitin ligase commonly functions as an anti-tumor role. Objective: This study probed the effect of E3 ligase NEDD4L on A549 cells. Methods: NEDD4L expression in NSCLC and its correlation with NSCLC patient's prognosis were predicted and verified. PD-L1 protein level was measured, and the correlation between NEDD4L and PD-L1 was analyzed. The effects of NEDD4L overexpression on the binding of NEDD4L to PD-L1 and ubiquitination level of PD-L1 were examined. Xenograft tumor model was established in mice. The volume and weight of xenograft tumors were recorded. The proportion of CD8+ T cells and contents of IL-2 and INF-γ were detected. Results: NEDD4L expression was downregulated in NSCLC tissues and A549 cells, and correlated with poor prognosis of NSCLC patients. PD-L1 was upregulated in NSCLC and negatively correlated with NEDD4L. Overexpression of NEDD4L upregulated ubiquitination level of PD-L1 and reduced protein level of PD-L1. Overexpression of NEDD4L decreased tumor volume and weight and enhanced proportion of CD8+ T cells and contents of IL-2 and INF-γ. Conclusions: Collectively, overexpression of NEDD4L suppressed PD-L1 protein level through ubiquitination, thereby enhancing anti-tumor immune response and retarding NSCLC progression.