Synthesis of Substituted Oxazoles by Visible-Light Photocatalysis

Chatterjee, Tanmay,Cho, Ji Young,Cho, Eun Jin American Chemical Society etc. 2016 Journal of organic chemistry Vol.81 No.16

<P>A simple and practical method for the synthesis of substituted oxazoles has been developed using readily available alpha-bromoketones and benzylamines by visible-light photocatalysis at room temperature. The process, which requires 1 mol % of [Ru(bpy)(3)]Cl-2 photocatalyst with K3PO4 and CCl3Br, is effective for accessing a variety of valuable oxazole compounds. The synthetic utility of our protocol was also demonstrated by preparing a natural prochict, texaline.</P>

Effect of coagulant addition on the sedimentation of a surfactant-containing washing solution used for phenanthrene-contaminated soil

Chatterjee, S.,Chatterjee, T.,Woo, S. H. KOREAN INSTITUTE OF CHEMICAL ENGINEER 2011 Korean Journal of Chemical Engineering Vol.28 No.12

Screening of toxic potential of graphene family nanomaterials using in vitro and alternative in vivo toxicity testing systems

Chatterjee, Nivedita,Yang, Ji Su,Park, Kwangsik,Oh, Seung Min,Park, Jeonggue,Choi, Jinhee The Korean Society of Environmental Toxicology 2015 환경독성보건학회지 Vol.30 No.-

Objectives The widely promising applications of graphene nanomaterials raise considerable concerns regarding their environmental and human health risk assessment. The aim of the current study was to evaluate the toxicity profiling of graphene family nanano-materials (GFNs) in alternative in vitro and in vivo toxicity testing models. Methods The GFNs used in this study are graphene nanoplatelets ([GNPs]-pristine, carboxylate [COOH] and amide [$NH_2$]) and graphene oxides (single layer [SLGO] and few layers [FLGO]). The human bronchial epithelial cells (Beas2B cells) as in vitro system and the nematode Caenorhabditis elegans as in vivo system were used to profile the toxicity response of GFNs. Cytotoxicity assays, colony formation assay for cellular toxicity and reproduction potentiality in C. elegans were used as end points to evaluate the GFNs' toxicity. Results In general, GNPs exhibited higher toxicity than GOs in Beas2B cells, and among the GNPs the order of toxicity was pristine > $NH_2$ > COOH. Although the order of toxicity of the GNPs was maintained in C. elegans reproductive toxicity, but GOs were found to be more toxic in the worms than GNPs. In both systems, SLGO exhibited profoundly greater dose dependency than FLGO. The possible reason of their differential toxicity lay in their distinctive physicochemical characteristics and agglomeration behavior in the exposure media. Conclusions The present study revealed that the toxicity of GFNs is dependent on the graphene nanomaterial's physical forms, surface functionalizations, number of layers, dose, time of exposure and obviously, on the alternative model systems used for toxicity assessment.

Searching for boosted dark matter at ProtoDUNE

Chatterjee, Animesh,De Roeck, Albert,Kim, Doojin,Moghaddam, Zahra Gh.,Park, Jong-Chul,Shin, Seodong,Whitehead, Leigh H.,Yu, Jaehoon American Physical Society 2018 Physical Review D Vol.98 No.7

A systems toxicology approach reveals the Wnt-MAPK crosstalk pathway mediated reproductive failure in <i>Caenorhabditis elegans</i> exposed to graphene oxide (GO) but not to reduced graphene oxide (rGO)

Chatterjee, Nivedita,Kim, Youngho,Yang, Jisu,Roca, Carlos P.,Joo, Sang-Woo,Choi, Jinhee Informa UK (TaylorFrancis) 2017 Nanotoxicology Vol.11 No.1

<P>The potential hazards of graphene nanomaterials were investigated by exposing the nematode Caenorhabditis elegans to graphene oxide (GO) and reduced graphene oxide (rGO). The underlying mechanisms of the nano-bio interaction were addressed with an integrated systems toxicology approach using global transcriptomics, network-based pathway analysis, and experimental validation of the in-silico-derived hypotheses. Graphene oxide was found to reduce the worms' reproductive health to a greater degree than rGO, but it did not affect survival (24h endpoint). Comparative analysis of GO vs. rGO effects found that the wingless-type MMTV integration site family (Wnt) pathway and the mitogen-activated protein kinase (MAPK) pathway were evoked in GO- but not in rGO-exposed worms. We therefore hypothesized that crosstalk between the Wnt and MAPK pathways is responsible for C. elegans' reproductive sensitivity to GO exposure. By targeting the individual components of the Wnt-MAPK crosstalk pathway (with qPCR gene expression and mutant reproduction analysis), we found a signaling cascade of MOM-2 -> MOM-5 -> MOM-4 -> LIT-1 -> POP-1 -> EGL-5. Specifically, the activation of POP-1 (the TCF protein homolog) and subsequent repression of the Wnt/beta-catenin target gene (EGL-5), analyzed with target-gene-specific RNAi in POP-1 mutant [pop-1(q645)] worms, were the central mechanisms of reduced reproductive potential in the worms exposed to GO. Our results highlight the distinct biological and molecular mechanisms of GO and rGO exposure and the role of Wnt-MAPK pathway crosstalk in regulating GO-induced reproductive failure in in vivo systems, and they will contribute to the development of efficient and innocuous graphene applications as well to improvements in mechanism-based risk assessment.</P>

III-nitride nanowires for solar light harvesting: A review

Chatterjee, U.,Park, Ji-Hyeon,Um, Dae-Young,Lee, Cheul-Ro PERGAMON 2017 RENEWABLE AND SUSTAINABLE ENERGY REVIEWS Vol.79 No.-

<P><B>Abstract</B></P> <P>The world needs economical and sustainable alternate energy sources to combat the irreversible phenomenon like global warming. Solar photovoltaic technology, which converts sunlight directly to electricity, is the most potential candidate for alternate energy source. On the other hand, increasing global pollution due to energy emission compels the worldwide researcher community to deliberate over various green fuels. Recently due to numerous advancements hydrogen fuel cells are thought to be the green power source of 21st century and may develop the hydrogen economy. However, despite of many promising breakthroughs energy production harvesting solar light does not find wide spread applications due to their low efficiency associated with unsuccessful utilization of entire solar spectrum which leads researchers to consider materials with multi energy band gap. Due to their unique property of band gap tuning (~6.2eV for AlN to ~0.65eV for InN) III-nitride nanowire structures have been extensively investigated in the past decade in pursuit of multi band gap materials. Intensive research efforts have been paid into studying GaN, InN, InGaN, AlN and their different compositions. It is clear that this material family has enormous potential in harvesting solar energy to light the new dawn of clean and sustainable energy sources. In this article, we present an overview on recent advancements in III-nitride solar energy devices. We have made a review for more than 200 articles in this regard. All the recent developments in realizing III-nitride nanostructures and novel yet recent advances in III-nitride solar devices are reviewed in and its subsequent subsections. The III-nitride nanowire photovoltaic devices are discussed in whereas deals with the current progresses in artificial photosynthesis involving III-nitride nanowires. Finally in the present challenges in realizing high efficiency III-nitride nanowire solar energy devices are summarized along with paths for future work.</P>

Differential genotoxic and epigenotoxic effects of graphene family nanomaterials (GFNs) in human bronchial epithelial cells

Chatterjee, N.,Yang, J.,Choi, J. Elsevier Publishing Co 2016 Mutation research Vol.798 No.-

HPV and Cervical Cancer Epidemiology - Current Status of HPV Vaccination in India

Chatterjee, Sharmila,Chattopadhyay, Amit,Samanta, Luna,Panigrahi, Pinaki Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

Cervical cancer (CaCx) is the second most fatal cancer contributing to 14% of cancers in Indian females, which account for 25.4% and 26.5% of the global burden of CaCx prevalence and mortality, respectively. Persistent infection with high-risk human papilloma virus (HPV- strains 16 and 18) is the most important risk factor for precursors of invasive CaCx. Comprehensive prevention strategies for CaCx should include screening and HPV vaccination. Three screening modalities for CaCx are cytology, visual inspection with acetic acid, and HPV testing. There is no Indian national policy on CaCx prevention, and screening of asymptomatic females against CaCx is practically non-existent. HPV vaccines can make a major breakthrough in the control of CaCx in India which has high disease load and no organized screening program. Despite the Indian Government's effort to introduce HPV vaccination in the National Immunization Program and bring down vaccine cost, challenges to implementing vaccination in India are strong such as: inadequate epidemiological evidence for disease prioritization, duration of vaccine use, parental attitudes, and vaccine acceptance. This paper reviews the current epidemiology of CaCx and HPV in India, and the current status of HPV vaccination in the country. This article stresses the need for more research in the Indian context, to evaluate interventions for CaCx and assess their applicability, success, scalability and sustainability within the constraints of the Indian health care system.

AN ACCOUNT OF INDIAN ASTRONOMICAL HERITAGE FROM THE 5th CE to 12th CE

CHATTERJEE, SOMENATH The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

Astronomical observation is the beginning of scientific attitudes in the history of mankind. According to Indian tradition, there existed 18 early astronomical texts (siddhantas) composed by Surya, Pitamaha and many others. Varahamihira compiled five astronomical texts in a book named panchasiddhantika, which is now the link between early and later siddhantas. Indian scholars had no practice of writing their own names in their works, so, it is very difficult to identify them. Aryabhata is the first name noticed, in the book Aryabhatiya. After this point most astronomers and astro-writers wrote their names in their works. In this paper I have tried to analyze the works of astronomers like Aryabhata, Varahamihira, Brahmagupta, Bhaskara I, Vateswara, Sripati and Bhaskaracharya in a modern context and to obtain an account of Indian astronomical knowledge. Aryabhata is the first Indian astronomer who stated that the rising and setting of the Sun, the Moon and other heavenly bodies was due to the relative motion of the Earth caused by the rotation of the Earth about its own axis. He also estabished the 'yuga' theory (one Mahayuga = 432000 years). Varahamihira compiled panchasiddhantika and wrote Brihatsamhita. Brahmagupta is the most distinguished astronomer known to us. His two major works are i) Brahmasphutasiddhanta and ii) Khandkhadaka. Bhaskara I was the follower of Aryabhata. His three known works are Mahabhaskariya, Laghubhaskariya and Aryabhatiyabhasya. Vateswara follows Aryapaksha and Saurapaksha. His master work is Vateswarasiddhanta. Sripati, in his siddhantasekhara, gives the rules for determining the Moon's second inequality. Bhaskara II wrote the most comprehensive astronomical work in Indian astronomy. The result of these works is the account of the Indian astronomical heritage. These works are written in the Sanskrit language. A very few of these manuscripts have been translated in English but many are yet to be done. So, it is necessary to translate these astronomical texts into English with proper commentary for modern scholars. This paper will be helpful in this work.

Visible-Light-Induced Synthesis of Carbazoles by in Situ Formation of Photosensitizing Intermediate

Chatterjee, Tanmay,Roh, Geum-bee,Shoaib, Mahbubul Alam,Suhl, Chang-Heon,Kim, Jun Soo,Cho, Cheon-Gyu,Cho, Eun Jin American Chemical Society 2017 ORGANIC LETTERS Vol.19 No.7

<P>A visible-light-induced synthesis of N-H carbazoles from easily accessible 2,2'-diaminobiaryls in the absence of any external photosensitizer is reported. The process only requires BuONO and natural resources, visible light, and molecular oxygen for the synthesis of N-H carbazoles. Experimental and computational studies support that the in situ formation of a visible-light-absorbing photosensitizing intermediate, benzocinnoline N-imide, is responsible for the activation of triplet molecular oxygen to singlet oxygen that, in turn, promotes the synthesis of carbazole.</P>