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포스트 코로나 대비 항공종사자 건강증진 방안: 싱잉볼 명상을 중심으로
Changsun Song 한국항공우주의학협회 2023 항공우주의학회지 Vol.33 No.2
COVID-19 has severely impacted the aviation industry, with air travel declining sharply and airlines cutting capacity as a result. Additionally, many countries have closed their borders to block spread of the virus. Air traffic controllers and pilots have also experienced negative effects, in that the experience required to maintain proficiency has decreased over the past three years. This has resulted in financial problems for airlines and air traffic control facilities, leading to increased job uncertainty and a manpower imbalance. As air traffic volumes begin to increase again, air traffic controllers and pilots responsible for passenger safety may experience extreme stress and anxiety in new situations. To address this problem, healthcare methods are needed to help aviation professionals to overcome stress and reduce anxiety. Meditation can stabilize the autonomic nervous system, promote relaxation and comfort in the mind and body, and could aid in smooth metabolism by suppressing the sympathetic nerves that cause our bodies to feel tension and activating the parasympathetic nerves. However, achieving the benefits of meditation can require time and effort, and general meditation can be challenging for individuals experiencing physical pain. Therefore, singing bowl meditation is recommended, as it can easily induce a meditative state. The sounds produced by Tibetan singing bowls can promote meditation by tuning the alpha waves, theta waves, and gamma waves of electoencephalography. Singing bowl meditation is a beneficial method for individuals with limited time or physical disabilities due to work schedules, such as air traffic controllers and pilots, to easily access meditation.
Kang, Changsun,Gwon, Sian,Song, ChulGyu,Kang, Peter M.,Park, Seong-Cheol,Jeon, Jongho,Hwang, Do Won,Lee, Dongwon American Chemical Society 2017 ACS NANO Vol.11 No.6
<P>A thrombus (blood clot) is formed in injured vessels to maintain the integrity of vasculature. However, obstruction of blood vessels by thrombosis slows blood flow, leading to death of tissues fed by the artery and is the main culprit of various life-threatening cardiovascular diseases. Herein, we report a rationally designed nano medicine that could specifically image obstructed vessels and inhibit thrombus formation. On the basis of the physicochemical and biological characteristics of thrombi such as an abundance of fibrin and an elevated level of hydrogen peroxide (H2O2), we developed a fibrin-targeted imaging and antithrombotic nanomedicine, termed FTIAN, as a theranostic system for obstructive thrombosis. FTIAN inhibited the generation of H2O2 and suppressed the expression of tumor necrosis factor-alpha (TNF-alpha) and soluble CD40 ligand (sCD40L) in activated platelets, demonstrating its intrinsic antioxidant, anti-inflammatory, and antiplatelet activity. In a mouse model of ferric chloride (FeCl3)-induced carotid thrombosis, FTIAN specifically targeted the obstructive thrombus and significantly enhanced the fluorescence/photoacoustic signal. When loaded with the antiplatelet drug tirofiban, FTIAN remarkably suppressed thrombus formation. Given its thrombus-specific imaging along with excellent therapeutic activities, FTIAN offers tremendous translational potential as a nanotheranostic agent for obstructive thrombosis.</P>
Jung, Eunkyeong,Kang, Changsun,Lee, Jeonghun,Yoo, Donghyuck,Hwang, Do Won,Kim, Dohyun,Park, Seong-Cheol,Lim, Sang Kyoo,Song, Chulgyu,Lee, Dongwon American Chemical Society 2018 ACS NANO Vol.12 No.1
<P>A thrombus (blood clot), composed mainly of activated platelets and fibrin, obstructs arteries or veins, leading to various life-threatening diseases. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and an elevated level of hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>), we developed thrombus-specific theranostic (T-FBM) nanoparticles that could provide H<SUB>2</SUB>O<SUB>2</SUB>-triggered photoacoustic signal amplification and serve as an antithrombotic nanomedicine. T-FBM nanoparticles were designed to target fibrin-rich thrombi and be activated by H<SUB>2</SUB>O<SUB>2</SUB> to generate CO<SUB>2</SUB> bubbles to amplify the photoacoustic signal. In the phantom studies, T-FBM nanoparticles showed significant amplification of ultrasound/photoacoustic signals in a H<SUB>2</SUB>O<SUB>2</SUB>-triggered manner. T-FBM nanoparticles also exerted H<SUB>2</SUB>O<SUB>2</SUB>-activatable antioxidant, anti-inflammatory, and antiplatelet activities on endothelial cells. In mouse models of carotid arterial injury, T-FBM nanoparticles significantly enhanced the photoacoustic contrast specifically in thrombosed vessels and significantly suppressed thrombus formation. We anticipate that T-FBM nanoparticles hold great translational potential as nanotheranostics for H<SUB>2</SUB>O<SUB>2</SUB>-associated cardiovascular diseases.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2018/ancac3.2018.12.issue-1/acsnano.7b06560/production/images/medium/nn-2017-06560s_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn7b06560'>ACS Electronic Supporting Info</A></P>
Jung, Eunkyeong,Noh, Joungyoun,Kang, Changsun,Yoo, Donghyuck,Song, Chulgyu,Lee, Dongwon Elsevier 2018 Biomaterials Vol.179 No.-
<P><B>Abstract</B></P> <P>Muscles of peripheral artery disease (PAD) patients are under oxidative stress associated with a significantly elevated level of reactive oxygen species (ROS) including hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>). Curcumin is a major active constituent of turmeric and is well known for its highly potent antioxidant, anti-inflammatory and angiogenic effects. We previously reported antioxidant vanillyl alcohol-incorporated copolyoxalate (PVAX) which is designed to rapidly scavenge H<SUB>2</SUB>O<SUB>2</SUB> and release bioactive vanillyl alcohol and CO<SUB>2</SUB> in a H<SUB>2</SUB>O<SUB>2</SUB>-triggered manner. In this work, we developed curcumin-loaded PVAX (CUR-PVAX) nanoparticles as contrast-enhanced ultrasound imaging agents as well as on-demand therapeutic agents for ischemic injuries based on the hypothesis that PVAX nanoparticles generate echogenic CO<SUB>2</SUB> bubbles through H<SUB>2</SUB>O<SUB>2</SUB>-triggered oxidation of peroxalate esters and the merger of curcumin and PVAX exerts H<SUB>2</SUB>O<SUB>2</SUB>-activatable synergistic therapeutic actions. CUR-PVAX nanoparticles also displayed the drastic ultrasound signal in ischemic areas by generating CO<SUB>2</SUB> bubbles. CUR-PVAX nanoparticles exhibited significantly higher antioxidant and anti-inflammatory activities than empty PVAX nanoparticles and equivalent curcumin in vascular endothelial cells. A mouse model of ischemic injury was used to evaluate the potential of CUR-PVAX nanoparticles as ultrasound imaging agents and on-demand therapeutic agents. CUR-PVAX nanoparticles significantly suppressed the expression of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β). Moreover, CUR-PVAX nanoparticles significantly enhanced the level of vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (PECAM-1, also known as CD31), leading to blood perfusion into ischemic tissues. We, therefore, believe that CUR-PVAX nanoparticles hold great translational potential as novel theranostic agents for ischemic diseases such as PAD.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Adverse fetal outcomes in pregnant rabbits experimentally infected with rabbit hepatitis E virus
Ahn, Hee-Seop,Han, Sang-Hoon,Kim, Yong-Hyun,Park, Byung-Joo,Kim, Dong-Hwi,Lee, Joong-Bok,Park, Seung-Yong,Song, Chang-Seon,Lee, Sang-Won,Choi, Changsun,Myoung, Jinjong,Choi, In-Soo 3M Company 2017 Virology Vol.512 No.-
<P>Hepatitis E virus (HEV) causes severe hepatitis in pregnant women, with associated poor fetal outcomes. To study HEV viral pathogenesis, pregnant rabbits were infected with low-and high-dose rabbit HEV at 2 weeks gestation. HEV was identified in the serum, feces, and liver tissue of infected rabbits, and dose-dependent fetal mortality rates ranging from 67% to 80% were observed. The aspartate transaminase (AST)/alanine transaminase ratio was significantly higher (P < 0.01) in high-dose infected rabbits than low-dose infected and negative control rabbits 14 days post infection (dpi). Tumor necrosis factor-alpha (TNF-alpha) was significantly higher in low dose (P < 0.01) and high-dose infected rabbits (P < 0.001) than in negative controls 7 dpi. High-dose HEV-infected rabbits produced significantly more interferon-gamma (IFN-gamma; P < 0.05) than negative control rabbits at 7 and 14 dpi. High levels of AST, TNF-alpha, and IFN-gamma may substantially influence adverse fetal outcomes in pregnant rabbits infected with high-dose HEV.</P>