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Rafael Carlos Sochodolak,Julio Cezar Schamn,Juliana Campos Ressetti,Bruno Margueritte Costa,Edher Lucas Antunes,Nilo Massaru Okuno 한국운동재활학회 2022 JER Vol.18 No.2
The aim of this study was to compare the physical fitness and cardiac autonomic activity among women with moderate and severe fibromyalgia (FM) and healthy women. This study included 35 women with FM (age: 46.2± 8.9 years) and 17 healthy women (age: 44.3± 9.9 years). Participants with FM were divided into moderate FM (n= 15) and severe FM (n= 20) according to the total score obtained in FM impact questionnaire. The heart rate variability was monitored using a portable cardiac monitor with participants resting in supine position during 10 min. Thereafter, the participants performed the chair sit and reach test, the chair stand test, and the 6-min walk test to measure the lower-body flexibility, lower-body muscle strength, and cardiorespiratory fitness, respectively. The lower-body muscle strength and cardiorespiratory fitness were both reduced in moderate and severe FM compared to healthy women (P< 0.01), with greater reduction in severe FM when compared to moderate FM (P< 0.05). In addition, the parasympathetic indexes of heart rate variability were all similarly decreased in both moderate and severe FM, when compared to healthy women (P< 0.05). The cardiac parasympathetic activity is similarly decreased in women with both moderate and severe FM in comparison to healthy women, despite a greater physical deconditioning in severe FM.
Thakur, P.,Kumar, R.,Cezar, J.C.,Brookes, N.B.,Sharma, A.,Arora, S.K.,Gautam, S.,Kumar, A.,Chae, K.H.,Shvets, I.V. North Holland 2011 Chemical physics letters Vol.501 No.4
We report on the element-specific magnetic characterization of Ni nanoparticles (NPs) embedded in Al<SUB>2</SUB>O<SUB>3</SUB> (001) matrix prepared by ion-implantation (Ni:5x10<SUP>16</SUP>-2x10<SUP>17</SUP>ionscm<SUP>-2</SUP>) technique. The X-ray diffraction studies reveal the coexistence of fcc Ni NPs of average size ~8-19nm along with the other NiO<SUB>x</SUB> phases. X-ray magnetic circular dichroism (XMCD) experiments demonstrate the competing nature of magnetic interactions between the Ni NPs and NiO<SUB>x</SUB> phases. The ferromagnetism at 10K (for all the Ni implants) is related to the combined contribution of both phases, while the room temperature superparamagnetism at higher fluence is dominated by Ni NPs phase as confirmed by Ni L<SUB>3,2</SUB> XMCD measurements.
Ndel1 and Reelin Maintain Postnatal CA1 Hippocampus Integrity
Jiang, Yulan,Gavrilovici, Cezar,Chansard, Mathieu,Liu, Rui Han,Kiroski, Ivana,Parsons, Kari,Park, Sang Ki,Teskey, G. Campbell,Rho, Jong M.,Nguyen, Minh Dang Society for Neuroscience 2016 The Journal of neuroscience Vol.36 No.24
<P>How the integrity of laminar structures in the postnatal brain is maintained impacts neuronal functions. Ndel1, the mammalian homolog of NuDE from the filamentous fungus Aspergillus nidulans, is an atypical microtubule (MT)-associated protein that was initially investigated in the contexts of neurogenesis and neuronal migration. Constitutive knock-out mice for Ndel1 are embryonic lethal, thereby necessitating the creation a conditional knock-out to probe the roles of Ndel1 in postnatal brains. Here we report that CA1 pyramidal neurons from mice postnatally lacking Ndel1 (Ndel1 conditional knock-out) exhibit fragmented MTs, dendritic/synaptic pathologies, are intrinsically hyperexcitable and undergo dispersion independently of neuronal migration defect. Secondary to the pyramidal cell changes is the decreased inhibitory drive onto pyramidal cells from interneurons. Levels of the glycoprotein Reelin that regulates MTs, neuronal plasticity, and cell compaction are significantly reduced in hippocampus of mutant mice. Strikingly, a single injection of Reelin into the hippocampus of Ndel1 conditional knock-out mice ameliorates ultrastructural, cellular, morphological, and anatomical CA1 defects. Thus, Ndel1 and Reelin contribute to maintain postnatal CA1 integrity.</P>
Expression of EGFR in Paired New and Recurrent Glioblastomas
Cioca, Andreea,Olteanu, Emilian Gheorghe,Gisca, Monica Daniela,Morosanu, Cezar Octavian,Marin, Irina,Florian, Ioan Stefan Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9
Background: The aim of this study was to analyse the expression of EGFR in newly diagnosed and recurrent glioblastoma multiforme (GBM). Materials and Methods: Our study included a total of 48 paired samples collected from 24 patients diagnosed with GBM. The intensity of EGFR cytoplasmatic staining was scored on a scale of 1-3+ (weak, intermediate or strong). Results: We found EGFR overexpression in 23 patients (96%) with newly diagnosed GBM, while all recurrent tumours overexpressed EGFR. Ten recurrent tumours (42%) had a lower expression than their new counterpart 13 tumours (54%) had a similar expression, and only one case (2%) had increased expression on recurrence. The expression of EGFR in newly diagnosed GBM was significantly correlated with EGFR expression in recurrent tumour (p = 0.036). In addition, new GBMs with strong EGFR expression had a mean relapse-free interval of 11.5 months (p=0.017). A benefit of combined therapy was observed in the radiotherapy-plus-chemotherapy group where the average time was 11 months (p=0.011), as compared with surgery/radiotherapy alone (average time 6.8 months). Conclusions: The present data show that EGFR is overexpressed in paired GBMs. The discrepancies of EGFR expression between the primary tumour and the recurrence suggest heterogeneity of GBMs but also unity at relapse.