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RISS 인기검색어
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- 저자 : Brandizzi, Daniel (검색결과 2 건)
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Expression of Ezrin and Metastatic Tumor Antigen in Osteosarcomas of the Jaw
Park, Hye-Rim,Cabrini, Romulo Luis,Araujo, Eduardo Santini,Paparella, Maria Luisa,Brandizzi, Daniel,Park, Yong-Koo SAGE Publications 2009 TUMORI Vol.95 No.1
<P>AIMS AND BACKGROUND: Ezrin is a membrane-cytoskeleton linker protein involved in regulation of the growth and metastatic behavior of cancer cells. Metastatic tumor antigen (MTA) is a potential metastasis-associated protein. The objective of this study was to evaluate the expression of ezrin and MTA and their correlation with clinicopathological features in osteosarcomas of the jaw. METHODS: We analyzed ezrin and MTA protein levels by immunohistochemistry in 31 osteosarcomas of the jaw. RESULTS: The mean age at diagnosis was 39 years and half of the patients were male. The mandible (n = 19) was more frequently involved than the maxilla (n = 12). The predominant histological type was chondroblastic (58.1%) and 24 patients (77.4%) were classified as having a high grade of malignancy. Immunoreactivity for ezrin was identified in 6 of 31 cases (19.4%), while 77.4% displayed expression of MTA. All ezrin-positive patients had high-grade tumors. The high-grade tumors (n = 24) had a higher rate of MTA expression (42.9% vs 87.5%). Expression of ezrin and MTA was not significantly different according to age, sex, tumor site, histological type, and tumor ploidy. Follow-up information was available for 13 patients, with a mean follow-up time of 26.7 months (range, 6-48 months). At the time of last follow-up, 5 (38.5%) patients had died of disease and 8 patients (61.5%) were alive with no evidence of disease. Expression of ezrin and MTA was not significantly different according to the follow-up data. CONCLUSIONS: In our study, high-grade tumors had a higher rate of ezrin and MTA expression. This expression pattern indicates that ezrin and MTA positivity can be additional prognostic markers in osteosarcoma of the jaw.</P>
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Kang, Jin-Ho,Campos, Marcelo L.,Zemelis-Durfee, Starla,Al-Haddad, Jameel M.,Jones, A. Daniel,Telewski, Frank W.,Brandizzi, Federica,Howe, Gregg A. Oxford University Press 2016 Journal of experimental botany Vol.67 No.18
<P>Trichomes are epidermal structures that provide a first line of defense against arthropod herbivores. The recessive <I>hairless</I> (<I>hl</I>) mutation in tomato (<I>Solanum lycopersicum</I> L.) causes severe distortion of trichomes on all aerial tissues, impairs the accumulation of sesquiterpene and polyphenolic compounds in glandular trichomes, and compromises resistance to the specialist herbivore <I>Manduca sexta</I>. Here, we demonstrate that the tomato <I>Hl</I> gene encodes a subunit (SRA1) of the highly conserved WAVE regulatory complex that controls nucleation of actin filaments in a wide range of eukaryotic cells. The tomato <I>SRA1</I> gene spans a 42-kb region containing both <I>Solyc11g013280</I> and <I>Solyc11g013290</I>. The <I>hl</I> mutation corresponds to a complex 3-kb deletion that removes the last exon of the gene. Expression of a wild-type <I>SRA1</I> cDNA in the <I>hl</I> mutant background restored normal trichome development, accumulation of glandular trichome-derived metabolites, and resistance to insect herbivory. These findings establish a role for <I>SRA1</I> in the development of tomato trichomes and also implicate the actin-cytoskeleton network in cytosolic control of specialized metabolism for plant defense. We also show that the brittleness of <I>hl</I> mutant stems is associated with altered mechanical and cell morphological properties of stem tissue, and demonstrate that this defect is directly linked to the mutation in <I>SRA1</I>.</P>
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