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RISS 인기검색어
- 검색키워드
- 저자 : Bothaina M. Abd El-Hady (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
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Basma Ekram,Bothaina M. Abd El-Hady,Abeer M. El-Kady,Sherif M. Amr,Hala Gabr,Ahmed I. Waly,Osiris W. Guirguis 한국섬유공학회 2019 Fibers and polymers Vol.20 No.4
Electrospun polycaprolactone is widely used in the medical field. Formic acid/acetic acid (FA/AA) solvent systemis one of the safest solvents used for the production of nano-range polycaprolactone (PCL) fibers, although it has a very lowstability. In the present study, the stability of PCL in FA/AA system was enhanced by sodium hydrogen carbonate (NaHCO3)addition with three different concentrations (1, 5 and 10 wt%). The resultant electrospun fiber properties were compared tothat treated by alkaline hydrolysis. The viscosity and conductivity of PCL solutions were measured before the electrospinningprocess. Moreover, the obtained electrospun PCL mats were characterized by SEM, FT-IR, XRD, contact anglemeasurements, degradability, swelling, and mechanical properties, as well as their ability to enhance the proliferation andadhesion of mesenchymal stem cells (MSCs). It was found that NaHCO3 not only enhanced the fiber properties, such ashydrophilicity, degradability and mechanical properties but also had a significant effect on the stability of polycaprolactone inFA/AA solvent system, as well as an enhanced MSCs proliferation and adhesion. Although hydrolyzed PCL showed high cellviability and adhesion, it showed much lower mechanical properties (0.7 MPa) compared to neat PCL (1.3 MPa) and PCLNaHCO3(5.1 MPa). In conclusion, the addition of NaHCO3 to PCL solution prior to the electrospinning process represents anovel and an effective approach to improve the physicochemical properties and biological behavior of electrospun PCL matsfor tissue engineering application.
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