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Full-range k-domain linearization in spectral-domain optical coherence tomography
Jeon, Mansik,Kim, Jeehyun,Jung, Unsang,Lee, Changho,Jung, Woonggyu,Boppart, Stephen A. The Optical Society 2011 Applied Optics Vol.50 No.8
<P>A full-bandwidth k-domain linearization method for spectral-domain optical coherence tomography (SD-OCT) is demonstrated. The method uses information of the wavenumber-pixel-position provided by a translating-slit-based wavelength filter. For calibration purposes, the filter is placed either after a broadband source or at the end of the sample path, and the filtered spectrum with a narrowed line width (??.5?m) is incident on a line-scan camera in the detection path. The wavelength-swept spectra are co-registered with the pixel positions according to their central wavelengths, which can be automatically measured with an optical spectrum analyzer. For imaging, the method does not require a filter or a software recalibration algorithm; it simply resamples the OCT signal from the detector array without employing rescaling or interpolation methods. The accuracy of k-linearization is maximized by increasing the k-linearization order, which is known to be a crucial parameter for maintaining a narrow point-spread function (PSF) width at increasing depths. The broadening effect is studied by changing the k-linearization order by undersampling to search for the optimal value. The system provides more position information, surpassing the optimum without compromising the imaging speed. The proposed full-range k-domain linearization method can be applied to SD-OCT systems to simplify their hardware/software, increase their speed, and improve the axial image resolution. The experimentally measured width of PSF in air has an FWHM of 8? at the edge of the axial measurement range. At an imaging depth of 2.5?m, the sensitivity of the full-range calibration case drops less than 10?B compared with the uncompensated case.</P>
Lee, Min Kyung,Rich, Max H.,Shkumatov, Artem,Jeong, Jae Hyun,Boppart, Marni D.,Bashir, Rashid,Gillette, Martha U.,Lee, Jonghwi,Kong, Hyunjoon Wiley (John WileySons) 2015 Advanced Healthcare Materials Vol.4 No.2
<P>This study demonstrates that a new method to align microparticles releasing bioactive molecules in microchannels of a hydrogel allows the guiding of growth direction and spacing of vascular networks.</P>
Handheld Optical Coherence Tomography Scanner for Primary Care Diagnostics
Jung, Woonggyu,Kim, Jeehyun,Jeon, Mansik,Chaney, Eric J.,Stewart, Charles N.,Boppart, Stephen A. IEEE 2011 IEEE Transactions on Biomedical Engineering Vol.58 No.3
<P>The goal of this study is to develop an advanced point-of-care diagnostic instrument for use in a primary care office using handheld optical coherence tomography (OCT). This system has the potential to enable earlier detection of diseases and accurate image-based diagnostics. Our system was designed to be compact, portable, user-friendly, and fast, making it well suited for the primary care office setting. The unique feature of our system is a versatile handheld OCT imaging scanner which consists of a pair of computer-controlled galvanometer-mounted mirrors, interchangeable lens mounts, and miniaturized video camera. This handheld scanner has the capability to guide the physician in real time for finding suspicious regions to be imaged by OCT. In order to evaluate the performance and use of the handheld OCT scanner, the anterior chamber of a rat eye and in vivo human retina, cornea, skin, and tympanic membrane were imaged. Based on this feasibility study, we believe that this new type of handheld OCT device and system has the potential to be an efficient point-of-care imaging tool in primary care medicine.</P>
조남현(Nam Hyun Cho),정웅규(Woonggyu Jung),정운상(Unsang Jung),Stephen A.Boppart,심재훈(Jae hoon Shim),김지현(Jeehyun Kim) 大韓電子工學會 2011 電子工學會論文誌-SC (System and control) Vol.48 No.1
본 연구에서는 안구 영상을 위한 OCT용 손잡이 형 프로브를 개발하였다. 프로브는 휴대하기 간편한 손잡이 형태로 구현하였으며, 어댑터의 대물렌즈를 교체함으로써 각막(cornea)과 망막(retina) 모두 영상화 할 수 있도록 설계 하였다. 시스템의 성능검증을 위해 in vivo 로 실험용 쥐의 눈 영상을 2D로 획득하였으며, 획득한 영상을 3D 영상으로 재구성하였다. 3D 영상은 쥐의 미세한 부분의 구조를 잘 나타내었으며, 움직임에 의한 흔들림 현상(Motion artifact)이 나타나지 않았으므로 개발된 OCT시스템의 이미지 디스플레이 속도는 생체 내 실험(in vivo)에 적합함을 알 수 있었다. We have developed a hand-held probe for an ophthalmic OCT system. The hand-held probe for imaging was designed to be compact and portable. The cornea and retinal images were acquired by replacing the objective lens at the front of the probe. To verify the performance of the hand-held OCT probe, we acquired two dimensional OCT image of the rat eye in vivo and reconstructed three dimensional rat eye rendering images. In vivo 3D OCT images were showed distinct structural information in the posterior and anterior chamber with minimal motion artifacts. Thereby, OCT imaging speed is suitable for an dynamic in vivo experiment.
Optical coherence tomography for advanced screening in the primary care office.
Shelton, Ryan L,Jung, Woonggyu,Sayegh, Samir I,McCormick, Daniel T,Kim, Jeehyun,Boppart, Stephen A Wiley 2014 Journal of Biophotonics Vol.7 No.7
<P>Optical coherence tomography (OCT) has long been used as a diagnostic tool in the field of ophthalmology. The ability to observe microstructural changes in the tissues of the eye has proved very effective in diagnosing ocular disease. However, this technology has yet to be introduced into the primary care office, where indications of disease are first encountered. We have developed a portable, handheld imaging probe for use in the primary care setting and evaluated its tissue site accessibility, ability to observe diseased tissue, and screening capabilities in in vivo human patients, particularly for pathologies related to the eye, ear and skin. Various stages of diabetic retinopathy were investigated using the handheld probe and early-stage diabetic retinopathy was flagged as abnormal from the OCT images. At such early stages of disease, it is difficult to observe abnormalities with the limited tools that are currently available to primary care physicians. These results indicate that OCT shows promise to transform from being a diagnostic technology in the medical and surgical specialities to a screening technology in the primary care office and at the front-line of healthcare.</P>
Park, Kibeom,Cho, Nam Hyun,Jang, Jeong Hun,Lee, Sang Heun,Kim, Pilun,Jeon, Mansik,Boppart, Stephen A.,Kim, Jeehyun,Jung, Woonggyu The Optical Society 2017 Applied Optics Vol.56 No.9
<P>A wide-field optical coherence tomography (OCT) probe was developed that adapts a diagonal-scanning scheme for three-dimensional (3D) in vivo imaging of the human tympanic membrane. The probe consists of a relay lens to enhance the lateral scanning range up to 7 mm. Motion artifacts that occur with the use of handheld probes were found to be decreased owing to the diagonal-scanning pattern, which crosses the center of the sample to facilitate entire 3D scans. 3D images could be constructed from a small number of two-dimensional OCT images acquired using the diagonal-scanning technique. To demonstrate the usefulness and performance of the developed system with the handheld probe, in vivo tympanic membranes of humans and animals were imaged in real time. (C) 2017 Optical Society of America.</P>