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- 저자 : Bonelli, Patricio (검색결과 4 건)
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IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes
Michael Bonelli,Karolina Dalwigk,Alexander Platzer,Isabel Olmos Calvo,Silvia Hayer,Birgit Niederreiter,Johannes Holinka,Florian Sevelda,Thomas Pap,Günter Steiner,Giulio Superti-Furga,Josef S. Smolen,H 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Rheumatoid arthritis (RA) is an autoimmune disease characterized by persistent synovial inflammation. The major drivers of synovial inflammation are cytokines and chemokines. Among these molecules, TNF activates fibroblast-like synoviocytes (FLSs), which leads to the production of inflammatory mediators. Here, we show that TNF regulates the expression of the transcription factor interferon regulatory factor 1 (IRF1) in human FLSs as well as in a TNF transgenic arthritis mouse model. Transcriptomic analyses of IRF1-deficient, TNF-stimulated FLSs define the interferon (IFN) pathway as a major target of IRF1. IRF1 expression is associated with the expression of IFNβ, which leads to the activation of the JAK-STAT pathway. Blocking the JAK-STAT pathway with the Janus kinase inhibitor (JAKinib) baricitinib or tofacitinib reduces the expression of IFN-regulated genes (IRGs) in TNF-activated FLSs. Therefore, we conclude that TNF induces a distinct inflammatory cascade, in which IRGs are key elements, in FLSs. The IFN-signature might be a promising biomarker for the efficient and personalized use of new treatment strategies for RA, such as JAKinibs.
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Study of hydrogen physisorption on nanoporous carbon materials of different origin
Armandi, M.,Bonelli, B.,Cho, K.,Ryoo, R.,Garrone, E. Elsevier 2011 INTERNATIONAL JOURNAL OF HYDROGEN ENERGY - Vol.36 No.13
<P><B>Abstract</B></P><P>Hydrogen adsorption capabilities of different nanoporous carbon, i.e. amorphous carbons obtained by chemical activation (with KOH) of a sucrose-derived char previously ground by ball milling and carbon replicas of NH<SUB>4</SUB>-Y and mesocellular silica foam (MSU-F) inorganic templates, were measured and correlated to their porous properties. The porous texture of the prepared carbon materials was studied by means of N<SUB>2</SUB> and CO<SUB>2</SUB> adsorption isotherms measured at −196°C and 0°C, respectively. Comparison with nanoporous carbons obtained without pre-grinding the sucrose-derived char <ce:cross-ref refid='bib12'>[12]</ce:cross-ref> shows that the ball milling procedure favours the formation of highly microporous carbon materials even at low KOH loadings, having a beneficial effect of the interaction between the char particles and the activating agent. Hydrogen adsorption isotherms at −196°C were measured in the 0.0–1.1MPa pressure range, and a maximum hydrogen adsorption capacity of 3.4 wt.% was obtained for the amorphous carbon prepared by activation at 900°C with a KOH/char weight ratio of 2. Finally, a linear dependence was found between the maximum hydrogen uptake at 1.1MPa and the samples microporous volume, confirming previous results obtained at −196°C and sub-atmospheric pressure <ce:cross-ref refid='bib12'>[12]</ce:cross-ref>.</P>
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Seismic Performance of High-rise Concrete Buildings in Chile
Lagos, Rene,Kupfer, Marianne,Lindenberg, Jorge,Bonelli, Patricio,Saragoni, Rodolfo,Guendelman, Tomas,Massone, Leonardo,Boroschek, Ruben,Yanez, Fernando Council on Tall Building and Urban Habitat Korea 2012 International journal of high-rise buildings Vol.1 No.3
Chile is characterized by the largest seismicity in the world which produces strong earthquakes every $83{\pm}9years$ in the Central part of Chile, where it is located Santiago, the capital of Chile. The short interval between large earthquakes magnitude 8.5 has conditioned the Chilean seismic design practice to achieve almost operational performance level, despite the fact that the Chilean Code declares a scope of life safe performance level. Several Indexes have been widely used throughout the years in Chile to evaluate the structural characteristics of concrete buildings, with the intent to find a correlation between general structural conception and successful seismic performance. The Indexes presented are related only to global response of buildings under earthquake loads and not to the behavior or design of individual elements. A correlation between displacement demand and seismic structural damage is presented, using the index $H_o/T$ and the concrete compressive strain ${\varepsilon}_c$. Also the Chilean seismic design codes pre and post 2010 Maule earthquake are reviewed and the practice in seismic design vs Performance Based Design is presented. Performance Based Design procedures are not included in the Chilean seismic design code for buildings, nevertheless the earthquake experience has shown that the response of the Chilean buildings has been close to operational. This can be attributed to the fact that the drift of most engineered buildings designed in accordance with the Chilean practice falls below 0.5%. It is also known by experience that for frequent and even occasional earthquakes, buildings responded elastically and thus with "fully operational" performance. Taking the above into account, it can be said that, although the "basic objective" of the Chilean code is similar to the SEAOC VISION2000 criteria, the actual performance for normal buildings is closer to the "Essential/Hazardous objective".
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Development of microporous-activated carbons derived from two renewable precursors for CO2 capture
Gomez-Delgado E.,Nunell G. V.,Cukierman A. L.,Bonelli P. R. 한국탄소학회 2020 Carbon Letters Vol.30 No.2
Wood sawdust from an invasive arboreal species, Parkinsonia aculeata, and seeds from a tropical fruit of massive consump�tion, Pouteria sapota, were used as precursors for the development of activated carbons (ACs) directed to CO2 adsorption. Chemical activation employing KOH as activating agent and pre-established experimental conditions was applied. Main physicochemical properties of the ACs in relation to their CO2 adsorption performance were examined. The ACs developed from the wood sawdust and the seeds presented specifc surfaces areas of 770 and 1000 m2 g−1, respectively, with their porosity development resulting essentially microporous (< 2 nm). They also showed a similar content of acidic surface groups, but basic functionalities of the former duplicated those of the latter. Maximum CO2 adsorbed at equilibrium (273 K and 100 kPa) was 5.0 mmol g−1 and 4.4 mmol g−1 for the samples derived from the sawdust and the seeds, respectively. On the other hand, CO2 adsorption capacities mimicking post-combustion conditions, as evaluated from thermogravimetric assays and breakthrough curves obtained in a packed-bed column, were approximately 1 mmol g−1, indicating a good CO2 adsorption performance for both ACs. Nevertheless, those derived from the wood sawdust with a notorious preeminence of micropores (~ 93%), narrower pore size distribution centered around 1 nm, and a higher content of basic functionalities than the ACs obtained from the seeds showed a relatively better performance. The CO2 removal capacity of the activated carbons was not noticeably afecte
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