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Bobone, Sara,Roversi, Daniela,Giordano, Lorenzo,De Zotti, Marta,Formaggio, Fernando,Toniolo, Claudio,Park, Yoonkyung,Stella, Lorenzo American Chemical Society 2012 Biochemistry Vol.51 No.51
<P>Antimicrobial peptides usually kill bacteria by making their membranes permeable. Two main models (barrel-stave and Shai–Matsuzaki–Huang) have been proposed to describe the peptide-induced pores. Although several experimental tests can be exploited to discriminate between these two models, the dependence of peptide activity on lipid properties (intrinsic curvature and membrane thickness) is routinely used for this purpose. Here, we show that, contrary to what is currently accepted, this criterion is unreliable.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/2012/bichaw.2012.51.issue-51/bi3015086/production/images/medium/bi-2012-015086_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bi3015086'>ACS Electronic Supporting Info</A></P>