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Combining CFD/FEM/BEM/SEA to Predict Interior Vehicle Wind Noise
D. Blanchet,A. Golota 한국소음진동공학회 2014 한국소음진동공학회 학술대회논문집 Vol.2014 No.10
Recent developments in the prediction of the contribution of windnoise to the interior SPL have opened a realm of new possibilities in terms of i) how the convective and acoustic sources terms can be identified, ii) how the interaction between the source terms and the side glass can be described and finally iii) how the transfer path from the sources to the interior of the vehicle can be modelled. This work discusses in details these three aspects of wind noise simulation and recommends appropriate methods to deliver required results at the right time based on i) simulation and experimental data availability, ii) design stage at which a decision must be made and iii) time available to deliver these results. Several simulation methods are used to represent the physical phenomena involved such as CFD, FEM, BEM, FE/SEA Coupled and SEA. Furthermore, a 1D and 2D wavenumber transformation is used to extract key parameters such as the convective and the acoustic component of the turbulent flow from CFD and/or experimental data whenever available. This work focuses on the validation of the wind noise source characterization method and the vibroacoustic models on which the wind noise sources are applied.
Damien Chaste,Emmanuel Vian,Gregory Verhoest,Pascal Blanchet 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.2
Translocation renal cell carcinoma (RCC) is a family of rare tumors recently identifiedin the pediatric and young adult population. We report the first case of a young womanfrom French West Indies with sickle cell anemia who developed a translocation RCCt(6;11)(p21;q12). Usually people with the sickle cell condition are known to develop renalmedullary carcinoma (RMC). To our knowledge, this is the first case described inthe literature of a translocation RCC associated with sickle cell disease. Here we discussthe relation between translocation RCC, RMC, and sickle cell disease.
Sheka Yagub Aloyouni,Charis-Patricia Segeritz,Ashley M. Sherrid,Matthew J. Gold,Daniela I. M. Loeffler,Marie-Renée Blanchet,Bing Cai,Jeremy Hirota,Kelly M. McNagny,Tobias R. Kollmann 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.4
Purpose: Asthma is a chronic respiratory disorder that leads to inflammation and narrowing of the airways. Its global prevalence has attained epidemiclevels and treatment options that reach beyond temporary relief of symptoms are urgently needed. Since the processes leading to clinicallysymptomatic asthma start early in life, we set out to systematically evaluate a neonatal immunotherapeutic based on Listeria monocytogenes (Lm)for the control of allergic sensitization. Methods: We modified Lm to express the model allergen, ovalbumin (OVA), and tested the ability of neonatalimmunization with this strain to control allergic sensitization in a mouse model of OVA-induced asthma. Mice were immunized as newborns withlive or heat killed LmOVA or live Lm, followed 6 weeks later by allergic sensitization with OVA. In order to determine whether the TH1-polarizing effectof this vaccine vector inadvertently may exacerbate development of certain TH1-driven allergic diseases, mice immunized as newborns were assessedin a model of adult hypersensitivity pneumonitis (HP). Results: Both LmOVA and Lm-control vaccines were highly effective in providinglong-lasting protection from airway inflammation after only one immunization given perinatally. Serum antibody levels and lung cytokine productionsuggest that this prophylactic strategy is associated with an allergen specific TH1-dominated response. Specifically, LmOVA vaccinated mice displayedsignificantly elevated OVA-specific serum IgG2a, but no difference in anti-OVA IgE antibodies and only slightly decreased anti-OVA IgG1 antibodies. Importantly, Lm-based neonatal vaccination did not exacerbate Th1/Th17 driven HP, arguing against broad spectrum immune skewing. Conclusions:Our findings highlight the promise of early life Lm-based immunomodulatory interventions as a prophylactic strategy for allergic asthma.