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I.S.R.Punitha1,,Nalini Bhat3,,K.Rajendran1,,Arun Shirwaikar2,,Annie Shirwaikar1 한국생약학회 2005 Natural Product Sciences Vol.11 No.3
The aqueous extract of Coscinium fenestratum was studied for its antioxidant status in STZ-nicotinamide induced type 2 diabetic rats at two dose levels of 250 mg/kg and 500 mg/kg. At the end of theexperimental period, diabetic rats treated with aqueous extract at both dose levels showed a significant increase insuperoxide dismutase and catalase as compared to the untreated control. Similarly, a significant increase was alsoobserved in the levels of the non enzymatic antioxidants ceruloplasmin, ascorbic acid and tocopherol. The resultssuggest that the aqueous stem extract of C. fenestratum prevents type 2 diabetes mellitus induced oxidative stress.
Bhat, Gulzar,Bhat, Ashaqullah,Wani, Aadil,Sadiq, Nida,Jeelani, Samoon,Kaur, Rajinder,Masood, Akbar,Ganai, Bashir Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Cancer is a complex disease and the genetic susceptibility to it could be an outcome of the inherited difference in the capacity of xenobiotic metabolizing enzymes. Glutathione-S-transferases (GSTs) are phase II metabolizing enzymes whose various genotypes have been associated with increased risk of different types of cancer. Null mutations caused by the deletion of the entire gene result in the absence of the enzymatic activity and increase in the risk of developing cancer including chronic myeloid leukaemia (CML). In the present case-control study we evaluated the effect of null mutations in GSTM1 and GSTT1 genes on the risk of developing CML. The study included 75 CML patients (43 males and 32 females; age (mean ${\pm}$ S.D) $42.3{\pm}13.4$ years) and unrelated non-malignant controls (76 male and 48 females; age (mean ${\pm}$ S.D) $41.5{\pm}12.9$). The distribution of GSTM1 and GSTT1 genotypes in CML patients and controls was assessed by multiplex-PCR method. Logistic regression was used to assess the relationship between GSTM1 and GSTT1 genotypes and risk of CML. Chi-square test was used to evaluate the trend in modulating the risk to CML by one or more potential high risk genotype. Although GSTM1 null genotype frequency was higher in CML patients (41%) than in the controls (35%), it did not reached a statistical significance (OD = 1.32, 95% CI: 0.73-2.40; P value = 0.4295). The frequency of GSTT1 null genotypes was higher in the CML patients (36%) than in the controls (21%) and the difference was found to be statistically significant (OD = 2.12, 95% CI: 1.12-4.02; P value = 0.0308). This suggests that the presence of GSTT1genotype may have protective role against the CML. We found a statistically significant (OD = 3.09, 95% CI: 1.122-8.528; P value = 0.0472) interaction between the GSTM1 and GSTT1 null genotypes and thus individuals carrying null genotypes of both GSTM1 and GSTT1 genes are at elevated risk of CML.
Bhat, Imtiyaz Ahmad,Pandith, Arshid A.,Bhat, Bashir A.,Naykoo, Niyaz A.,Qasim, Iqbal,Rasool, Roohi,Aziz, Sheik Aejaz,Shah, Zafar Amin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Background: Chronic inflammation is considered as an important factor in the pathogenesis of lung cancer. The presence of inflammatory cells and higher levels of pro-inflammatory cytokines in the tumor microenvironment and their surrounding tissues is gaining much importance in research. Materials and Methods: One hundred ninety NSCLC cases and 200 age, smoking and sex matched controls were evaluated for association of IL-8 -251 (rs4073) and IL-8 -845 (rs2227532) in our population. Restriction fragment length polymorphism (RFLP) was used followed by direct sequencing for the detection of SNPs. Results: The IL-8 -845 polymorphism was not found in our population. No significant association was observed between the IL-8 -251 AT genotypes and IL-8 -25 AA genotypes and NSCLC (p=0.05) in our population. The IL-8 -251 A allele was also non-significant (p=0.05) in NSCLC patients. Conclusions: In conclusion, this report reveals lack of association between IL-8 - 251 A/T polymorphism and NSCLC in our Kashmir Valley population.
(p, q)-ANALOGUE OF THE NATURAL TRANSFORM WITH APPLICATIONS
Altaf A. Bhat,Faiza A. Sulaiman,Javid A. Ganie,M. Younus Bhat,D.K. Jain 경남대학교 기초과학연구소 2023 Nonlinear Functional Analysis and Applications Vol.28 No.4
The natural transform is represented by two $(p,q)$-analogues,and their comparative characteristics are established. To resolve some $(p,q)$-difference and functional equations, applications are carried out.
ALTAF A. BHAT,M. YOUNUS BHAT,H. MAQBOOL,D.K. JAIN The Korean Society for Computational and Applied M 2023 Journal of applied mathematics & informatics Vol.41 No.2
In this paper we have obtained various forms of (p, q)-analogue of Aleph-Function satisfying Truesdell's ascending and descending F<sub>p,q</sub>-equation. These structures have been employed to arrive at certain generating functions for (p, q)-analogue of Aleph-Function. Some specific instances of these outcomes as far as (p, q)-analogue of I-function, H-function and G-functions have likewise been obtained.
Generating Operators of I-transform of the Mellin Convolution Type
Altaf A. Bhat,Javid A. Ganie,M. Younus Bhat,Faiza B. Suleiman 한국전산응용수학회 2024 Journal of applied mathematics & informatics Vol.42 No.1
In this paper, the I-transform of the Mellin convolution type is presented. Based on the Mellin transform theory, a general integral transform of the Mellin convolution type is introduced. The generating operators for I-transform together with the corresponding operational relations are also presented.
Indu K Murthy,Savithri Bhat,Vani Sathyanarayan,Sridhar Patgar,Beerappa M,PR Bhat,DM Bhat,Ranjith Gopalakrishnan,Mathangi Jayaraman,Madhushree Munsi,Ravindranath NH,Khalid MA,Prashant M,Sudha Iyer,Ragh 강원대학교 산림과학연구소 2014 Journal of Forest Science Vol.30 No.2
The tropical wet evergreen, tropical semi evergreen and moist deciduous forest types are projected to be impacted by climate change. In the Western Ghats region, a biodiversity hotspot, evergreen forests including semi evergreen account for 30% of the forest area and according to climate change impact model projections, nearly a third of these forest types are likely to undergo vegetation type change. Similarly, tropical moist deciduous forests which account for about 28% of the forest area are likely to experience change in about 20% of the area. Thus climate change could adversely impact forest biodiversity and product flow to the forest dependent households and communities in Uttara Kannada district of the Western Ghats. This study analyses the distribution of non- timber forest product yielding tree species through a network of twelve 1-ha permanent plots established in the district. Further, the extent of dependence of communities on forests is ascertained through questionnaire surveys. On an average 21% and 28% of the tree species in evergreen and deciduous forest types, respectively are, non-timber forest product yielding tree species, indicating potential high levels of supply of products to communities. Community dependence on non-timber forest products is significant, and it contributes to Rs. 1199 and Rs. 3561/household in the evergreen and deciduous zones, respectively. Given that the bulk of the forest grids in Uttara Kannada district are projected to undergo change, bulk of the species which provide multiple forest products are projected to experience die back and even mortality. Incorporation of climate change projections and impacts in forest planning and management is necessary to enable forest ecosystems to enhance resilience.
Murthy, Indu K.,Bhat, Savithri,Sathyanarayan, Vani,Patgar, Sridhar,M., Beerappa,Bhat, P.R.,Bhat, D.M.,Gopalakrishnan, Ranjith,Jayaraman, Mathangi,Munsi, Madhushree,N.H., Ravindranath,M.A., Khalid,M., Institute of Forest Science 2014 Journal of Forest Science Vol.30 No.2
The tropical wet evergreen, tropical semi evergreen and moist deciduous forest types are projected to be impacted by climate change. In the Western Ghats region, a biodiversity hotspot, evergreen forests including semi evergreen account for 30% of the forest area and according to climate change impact model projections, nearly a third of these forest types are likely to undergo vegetation type change. Similarly, tropical moist deciduous forests which account for about 28% of the forest area are likely to experience change in about 20% of the area. Thus climate change could adversely impact forest biodiversity and product flow to the forest dependent households and communities in Uttara Kannada district of the Western Ghats. This study analyses the distribution of non-timber forest product yielding tree species through a network of twelve 1-ha permanent plots established in the district. Further, the extent of dependence of communities on forests is ascertained through questionnaire surveys. On an average 21% and 28% of the tree species in evergreen and deciduous forest types, respectively are, non-timber forest product yielding tree species, indicating potential high levels of supply of products to communities. Community dependence on non-timber forest products is significant, and it contributes to Rs. 1199 and Rs. 3561/household in the evergreen and deciduous zones, respectively. Given that the bulk of the forest grids in Uttara Kannada district are projected to undergo change, bulk of the species which provide multiple forest products are projected to experience die back and even mortality. Incorporation of climate change projections and impacts in forest planning and management is necessary to enable forest ecosystems to enhance resilience.
Bhat Shabir Ahmad,Nataraju B. Korean Society of Sericultural Science 2006 International Journal of Industrial Entomology Vol.12 No.1
Lamerin breed of the silkworm Bombyx mori L. is the only mulberry silkworm breed which survives with an associated microsporidian $(Lb_{ms})$ infection from generations. This present comparative investigation has produced information on the influence of $Lb_{ms}$ on the growth and development of the breed. The $Lb_{ms}$ transmits tranovarially as well as perorally at low level. Larvae developed from the eggs laid by female, infected with $Lb_{ms}$ were as normal as larvae developed from the eggs laid by healthy female. In infected tissues early developmental stages and mature spores located intracellularly but did not show hypertrophy of cells of the host. The meronts and sporonts measures $0.46{\pm}0.25,\;1.11{\pm}0.05{\mu}m$ in length and $0.32{\pm}0.05,\;0.78{\pm}0.10{\mu}m$ in width respectively. The mature spore measures $4.36{\pm}0.06{\mu}m$ in length and $2.14{\pm}0.01{\mu}m$ in width.
Nozzle-jet printed flexible field-effect transistor biosensor for high performance glucose detection
Bhat, Kiesar Sideeq,Ahmad, Rafiq,Yoo, Jin-Young,Hahn, Yoon-Bong Elsevier 2017 JOURNAL OF COLLOID AND INTERFACE SCIENCE - Vol.506 No.-
<P><B>Abstract</B></P> <P>Printable electronics is a subject of great interest for low-cost, facile and environmentally-friendly large scale device production. But, it still remains challenging for printable biosensor development. Herein, we present the fabrication of nozzle-jet printed flexible field-effect transistor (FET) glucose biosensor. The silver source-drain electrodes and ZnO seed layers were printed on flexible substrate by nozzle-jet printer followed by ZnO nanorods (ZnO NRs) synthesis and glucose oxidase (GOx) immobilization. Utilization of nozzle-jet printing methods resulted in highly reproducible electrodes with well-defined vertical grown ZnO NRs for high GOx loading and enhanced glucose sensing performance in a wide glucose detection range. The stability, anti-interference ability, reproducibility, reusability, and applicability in human serum samples were also assessed. Overall, biosensor fabrication using nozzle-jet printer will not only provide large scale production of highly reproducible electrodes but also reduce the fabrication cost. Additionally, printed electrodes can be modified accordingly for different analyte detection.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nozzle-jet printing of silver source-drain electrodes and ZnO seed layers on flexible substrate. </LI> <LI> Use of nozzle-jet printer resulted in high reproducible sensing active area. </LI> <LI> Growth of well-defined vertical ZnO NRs for high enzyme loading and enhanced sensing performance. </LI> <LI> Sensor showed wide glucose detection range, long-term stability and excellent reproducibility. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>