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Cytotoxic triterpenoids from Saussurea phyllocephala
Jiang Hu,Yan Song,Benshou Yang,Xiang Zuo,Xiao Mao,Xiaodong Shi 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.12
Three new triterpenoids, 11a-hydroxy-lup-20(29)-ene-3b-palmitate (1), 28-hydroxy-20-oxo-30-norlupane-3b-palmitate (2), and 1b,11a,28-tyrihydroxy oleana-9(11),12-dien-3b-palmitate (3), together with threeknown compounds were isolated from the 95 % EtOHextract of Saussurea phyllocephala. The structures of thenew compounds were elucidated on the basis of 1D and 2DNMR (COSY, HMQC, HMBC and NOESY) analyses. Allthe triterpenoids were in vitro evaluated for their cytotoxicactivities. Compound 1–3 exhibited the significant cytotoxicactivities with low IC50 values (IC50\4.0 lM)against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460 and BGC-823).
Cytotoxic triterpene glycosides from the roots of Sanguisorba officinalis
Jiang Hu,Yan Song,Hui Li,Benshou Yang,Xia Mao,Yongmao Zhao,Xiaodong Shi 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Phytochemical investigation of the ethanolextract of the roots of Sanguisorba officinalis resulted inthe isolation of three new triterpene glycosides, 3b-[(a-Larabinopyranosyl)oxy]-19a,23-dihydroxyolean-12-en-28-oicacid 28-[6-O-acetyl-b-D-glucopyranosyl] ester (1),2a,3b,19a,23-tetrahydroxyurs-12-en-28-oic acid 28-[6-Oacetyl-b-D-glucopyranosyl] ester (2), and 3b-[(a-L-arabinopyranosyl)oxy]-19a-hydroxyurs-12,20(30)-dien-28-oicacid 28-[6-O-acetyl-b-D-glucopyranosyl] ester (3). All thetriterpene glycosides exhibited the significant cytotoxicpotential with low IC50 values (IC50\5.0 lM) against sixtumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCIH460,and BGC-823).