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Bayda, Malgorzata,Hug, Gordon L.,Lukaszewicz, Jakub,Majchrzak, Mariusz,Marciniec, Bogdan,Marciniak, Bronislaw Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.12
The kinetics scheme for directly excited, photoreversible reactions is solved exactly under the assumptions of no irreversible side reactions and constant excitation intensity for the duration of the reaction. The advantages of the methodology over the extrapolation-to-zero-time and the back-reaction correction methods are (i) that the quantum yields of both the forward and reverse photoreactions can be obtained starting from either pure reactant or pure product and (ii) the conversion percentage is not limited to a narrow domain in the neighborhood of small conversions. Examples of E-Z photoisomerizations are given to illustrate the fitting procedures required. The results from these examples are compared to the photoisomerization method of extrapolating the empirical quantum yields to zero time and the back-reaction correction. The exact equations are used to justify the extrapolation-to-zero-time method and to establish criteria on extrapolation ranges for the conversion percentage of starting material.
The prognostic value of tumor budding in gastric adenocarcinomas: A cross-sectional study
Baydas Tuba,Coban Ganime,Besiroglu Mehmet,Simsek Melih,Shbair Abdallah TM,Topcu Atakan,Yasin Ayse Irem,Seker Mesut,Turk Haci Mehmet 소화기인터벤션의학회 2023 International journal of gastrointestinal interven Vol.12 No.2
Background: Tumor budding is a negative prognostic factor for many solid malignancies. We investigated the relationship between patients’ clinico-pathological characteristics and tumor budding, as well as the effect of budding level on prognosis. Methods: In this retrospective, cross-sectional, and descriptive study at a tertiary university hospital, 104 patients with gastric adenocarcinoma were divided into two groups according to whether they had a high (≥ 10 buds) or low (< 10 buds) level of budding. The patients were retrospectively evaluated.Results: Sixty-two patients had a low level of budding and 42 had a high level of budding. The mean time from the first diagnosis to the last follow-up was significantly longer (P < 0.05) in the low-budding group (27 months) than in the high-budding group (17 months). As the T stage, N stage, grade, and size of the tumor increased, the proportion of patients with high budding was found to be significantly higher (P < 0.05). High tumor budding, an age of 60 or over at diagnosis, a low body mass index, high N stage, presence of lymphovascular invasion, and recurrence were associ-ated with overall survival.Conclusion: Our study supports that budding is a negative prognostic factor in gastric cancer.