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A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication
Lee, Mi-Kyung,Bottini, Angel,Kim, Meehyein,Bardaro, Michael F.,Zhang, Ziming,Pellecchia, Maurizio,Choi, Byong-Seok,Varani, Gabriele The Royal Society of Chemistry 2014 Chemical communications Vol.50 No.3
<P>Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA–DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.</P> <P>Graphic Abstract</P><P>A novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) exhibiting anti-influenza cellular activity identified by NMR screening binds to the internal loop of the influenza A virus RNA promoter. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc46973e'> </P>