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Laurentine Bouquet Tankeu Nyaa,Luciano Barboni,Pierre Tane,Hee-Juhn Park,Léon Azefack Tapondjou,Jean De Dieu Tamokou,Jules Roger Kuiaté 한국생약학회 2009 Natural Product Sciences Vol.15 No.2
Phytochemical investigation of the EtOAc and n-BuOH fractions obtained from the crude methanol extract of the seeds of Butyrospermum parkii led to the isolation of seven compounds including 1β,2α,3α- trihydroxyurs-12-en-28-oic acid (1β-hydroxyeuscaphic acid) which full NMR assignment is herein reported for the first time. The above extract, fractions and some of the isolated compounds were screened for antimicrobial and antioxidant activities; 1β-hydroxyeuscaphic acid was the more potent.
Antioxidant C-glycosylflavones of Drymaria cordata (Linn.) Willd
Raymond N. Nono,Laurence K. Nzowa,Beaudelaire K. Ponou,Re´my B. Teponno,Te´lesphore B. Nguelefack,Luciano Barboni,Le´on A. Tapondjou,박희준 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.1
A new C-glycosylflavone, drymaritin E (6-C- (3-keto-b-digitoxopyranosyl)-40-O-(b-D-glucopyranosyl)- 7-methoxyl-5,40-dihydroxylflavone) 1 was isolated from the oily upper phase (SU) of the MeOH extract from aerial parts of Drymaria cordata together with two known compounds (cassiaoccidentalin A 2 and anemonin 3) and an inseparable mixture of two known C-glycosylflavones 5,40- dihydroxy-7-methoxyflavone-6-C-(200-O-a-L-rhamnopyranosyl)- b-D-glucopyranoside 4a and 5,7,30,40-tetrahydroxyflavone- 6-C-(200-O-a-L-rhamnopyranosyl)-b-D-glucopyranoside 4b. The alkaline hydrolysis of 3 led to a new hemisynthetic derivative, sodium anemonate (sodium 2-((1’E) 20-sodium-carboxylate-vinyl)-5-oxo-cyclohex- 1-ene carboxylate) 3a. The chemical structures were determined by spectroscopic methods (1H NMR, 13C NMR, 1H-1H COSY, HMBC, HSQC, and NOESY) and mass spectrometry (ESI–MS). C-glycosylflavones had significant free radical-scavenging activities on the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). However, SU and compounds 3 and 3a exhibited no activity. In particular, compound 1 exhibited a concentration-dependent radical scavenging activity on DPPH with EC50 of 31.43 lg/mL.
Immunonutrition in ovarian cancer: clinical and immunological impact?
Annamaria Ferrero,Daniela Vassallo,Massimo Geuna,Luca Fuso,Michela Villa,Enrico Badellino,Martina Barboni,Paola Coata,Nathalie Santoro,Roberto C. Delgado Bolton,Nicoletta Biglia 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.6
Objective: Malnutrition is frequent in ovarian cancer (OC) patients and may compromise post-operative outcomes. The aim of this study is to evaluate the impact of pre-operative immunonutrition on the surgical outcome of OC patients, and on their nutritional, inflammatory and peripheral blood immune status. Methods: A prospective study was performed between September 2016 and April 2020. Immune-enhancing enteral nutrition was administered to 42 patients before surgery according to their nutritional status assessed by the Malnutritional Universal Screening Tool. Biochemical and hematological monitoring was performed before and after immunonutrition. Post-operative outcomes were assessed and compared with those of a similar group of patients treated without nutritional support. Results: Of the 42 immune-nourished patients, 23 (54.8%) had a low, 11 (26.2%) an intermediate and 8 (19%) a high risk of malnutrition. After the immunonutritional intake, significant variations of prealbumin, creatinine and white blood cells were detected. All T cell populations had an increasing trend, in particular CD3+ T lymphocytes (p=0.020), CD3+CD8+ cytotoxic T lymphocytes (p=0.046) and lymphocyte with HLA-DR expression (p=0.012). The rate of grade II–III post-operative complications was lower (21.4% vs. 42.9%, p=0.035) and the time of hospitalization was shorter (7.5 vs. 9.2, p=0.009) in the immune-nourished group. Conclusion: Pre-operative immunonutrition improves the surgical outcome of OC patients. After immunonutrition, an increase of CD3+CD8+ cytotoxic T lymphocytes was observed.