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RISS 인기검색어
- 검색키워드
- 저자 : Baghani, Hamid (검색결과 3 건)
- 무료
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- 유료
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Kadkhodazadeh, Mahdi,Baghani, Zahra,Ebadian, Ahmad Reza,Kaghazchi, Zahra,Amid, Reza Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.3
Purpose: Peri-implantitis and periodontitis are inflammatory and infectious diseases of implant and tooth-supporting tissues. Recently, the role of gene polymorphisms of immune response components in the relevant pathogenesis has been investigated. The present study was the first to evaluate the relationship between two known single nucleotide polymorphisms (SNPs) of the receptor activator of nuclear factor kappa-${\beta}$ (RANK) gene (rs3018362 and rs35211496) in chronic periodontitis and peri-implantitis patients in an Iranian population. Methods: Eighty-one periodontally healthy patients, 38 patients with peri-implantitis, and 74 patients with chronic periodontitis were enrolled in this study. DNA was extracted from blood arm vein samples by using Miller's salting out technique according to the manufacturer's instructions given in the extraction kit. The concentration of DNA samples was measured using a spectrophotometer. The genetic polymorphisms of the RANK gene were evaluated using a competitive allele specific polymerase chain reaction (KBioscience allele specific PCR) technique. Differences in the frequencies of genotypes and alleles in the diseased and healthy groups were analyzed using chi-squared statistical tests (P<0.05). Results: Analysis of rs35211496 revealed statistically significant differences in the expression of the TT, TC, and CC genotypes among the three groups (P=0.00). No statistically significant difference was detected in this respect between the control group and the chronic periodontitis group. The expression of the GG, GA, and AA genotypes and allele frequencies (rs3018362) showed no statistically significant difference among the three groups (P=0.21). Conclusions: The results of this study indicate that the CC genotype of the rs35211496 RANK gene polymorphism was significantly associated with peri-implantitis and may be considered a genetic determinant for peri-implantitis, but this needs to be confirmed by further studies in other populations.
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Mahdi Kadkhodazadeh,Zahra Baghani,Ahmad Reza Ebadian,Zahra Kaghazchi,Reza Amid 대한치주과학회 2014 Journal of Periodontal & Implant Science Vol.44 No.3
Purpose: Peri-implantitis and periodontitis are inflammatory and infectious diseases of implantand tooth-supporting tissues. Recently, the role of gene polymorphisms of immune responsecomponents in the relevant pathogenesis has been investigated. The present study wasthe first to evaluate the relationship between two known single nucleotide polymorphisms(SNPs) of the receptor activator of nuclear factor kappa-β (RANK) gene (rs3018362 andrs35211496) in chronic periodontitis and peri-implantitis patients in an Iranian population. Methods: Eighty-one periodontally healthy patients, 38 patients with peri-implantitis, and74 patients with chronic periodontitis were enrolled in this study. DNA was extracted fromblood arm vein samples by using Miller’s salting out technique according to the manufacturer’sinstructions given in the extraction kit. The concentration of DNA samples was measuredusing a spectrophotometer. The genetic polymorphisms of the RANK gene were evaluatedusing a competitive allele specific polymerase chain reaction (KBioscience allele specificPCR) technique. Differences in the frequencies of genotypes and alleles in the diseasedand healthy groups were analyzed using chi-squared statistical tests (P<0.05). Results: Analysis of rs35211496 revealed statistically significant differences in the expressionof the TT, TC, and CC genotypes among the three groups (P=0.00). No statistically significantdifference was detected in this respect between the control group and the chronicperiodontitis group. The expression of the GG, GA, and AA genotypes and allele frequencies(rs3018362) showed no statistically significant difference among the three groups (P=0.21). Conclusions: The results of this study indicate that the CC genotype of the rs35211496RANK gene polymorphism was significantly associated with peri-implantitis and may beconsidered a genetic determinant for peri-implantitis, but this needs to be confirmed byfurther studies in other populations.
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