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RESEARCH ACTIVITIES ON A SUPERCRITICAL PRESSURE WATER REACTOR IN KOREA
Bae, Yoon-Yeong,Jang, Jin-Sung,Kim, Hwan-Yeol,Yoon, Han-Young,Kang, Han-Ok,Bae, Kang-Mok Korean Nuclear Society 2007 Nuclear Engineering and Technology Vol.39 No.4
This paper presents the research activities performed to date for the development of a supercritical pressure water-cooled reactor (SCWR) in Korea. The research areas include a conceptual design of an SCWR with an internal flow recirculation, a reactor core conceptual design, a heat transfer test with supercritical $CO_2$, an adaptation of an existing safety analysis code to the supercritical pressure condition, and an evaluation of candidate materials through a corrosion study. Methods to reduce the cladding temperature are introduced from two different perspectives, namely, thermal-hydraulics and core neutronics. Briefly described are the results of an experiment on the heat transfer at a supercritical pressure, an experiment that is essential for the analysis of the subchannels of fuel assemblies and the analysis of a system safety. An existing system code has been adapted to SCWR conditions, and the process of a first-hand validation is presented. Finally, the corrosion test results of the candidate materials for an SCWR are introduced.
Feasibility and response of helical tomotherapy in patients with metastatic colorectal cancer
Bae, Sun Hyun,Moon, Seong Kwon,Kim, Yong Ho,Cho, Kwang Hwan,Shin, Eung Jin,Lee, Moon Sung,Ryu, Chang Beom,Ko, Bong Min,Yun, Jina The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.4
Purpose: To investigate the treatment outcome and the toxicity of helical tomotherapy (HT) in patients with metastatic colorectal cancer (mCRC). Materials and Methods: We retrospectively reviewed 18 patients with 31 lesions from mCRC treated with HT between 2009 and 2013. The liver (9 lesions) and lymph nodes (9 lesions) were the most frequent sites. The planning target volume (PTV) ranged from 12 to 1,110 mL (median, 114 mL). The total doses ranged from 30 to 70 Gy in 10-30 fractions. When the ${\alpha}/{\beta}$ value for the tumor was assumed to be 10 Gy for the biologically equivalent dose (BED), the total doses ranged from 39 to $119Gy_{10}$ (median, $55Gy_{10}$). Nineteen lesions were treated with concurrent chemotherapy (CCRT). Results: With a median follow-up time of 16 months, the median overall survival for 18 patients was 33 months. Eight lesions (26%) achieved complete response. The 1- and 3-year local progression free survival (LPFS) rates for 31 lesions were 45% and 34%, respectively. On univariate analysis, significant parameters influencing LPFS rates were chemotherapy response before HT, aim of HT, CCRT, PTV, BED, and adjuvant chemotherapy. On multivariate analysis, $PTV{\leq}113mL$ and $BED>48Gy_{10}$ were associated with a statistically significant improvement in LFPS. During HT, four patients experienced grade 3 hematologic toxicities, each of whom had also received CCRT. Conclusion: The current study demonstrates the efficacy and tolerability of HT for mCRC. To define optimal RT dose according to tumor size of mCRC, further study should be needed.
Inhibitory Effects of Phylligenin on the Proliferation of Cultured Rat Neural Progenitor Cells
( Sung Hoon Lee ),( Hyo Sang Go ),( Chang Soon Choi ),( Jae Hoon Cheong ),( Sun Young Han ),( Ki Hwan Bae ),( Kwang Ho Ko ),( Seung Hwa Park ) 한국응용약물학회 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.18 No.1
Bae, Ki Hwan,Koo, Sung Hyun,Seo, Won Jun 충남대학교 약학대학 의약품개발연구소 1991 藥學論文集 Vol.7 No.-
For the purpose of survey of the antibacterial activity against a cariogenic bacterium Streptococcus mutans OMZ 176 with the introduction of hydroxyl and allyl groups to o-phenylphenol (Fig. 2. 1). 4-hydroxy-o-phenylphenol (2), and 3.6-diallyl-4-hydroxy-o-phenylphenol (4) were synthesized, sucessively. The synthesized compounds, 2 and 4 showed more potent antibacterial activity than the starting meterial, 1. The hydroxyl group was supposed to the essential element for the antibacterial activity and the introduction of allyl group to phenolic ring to be another element to increase the activity.
Hwan-Deuk Kim,Hye-Jin Jeon,Min Jang,Seul-Gi Bae,Sung-Ho Yun,Jee-Eun Han,Seung-Joon Kim,Won-Jae Lee 한국동물생명공학회(구 한국동물번식학회) 2022 Journal of Animal Reproduction and Biotechnology Vol.37 No.2
The ovary undergoes substantial physiological changes along with estrus phase to mediate negative/positive feedback to the upstream reproductive tissues and to play a role in producing a fertilizable oocyte in the developing follicles. However, the disorder of estrus cycle in female can lead to diseases, such as cystic ovary which is directly associated with decline of overall reproductive performance. In gene expression studies of ovaries, quantitative reverse transcription polymerase chain reaction (qPCR) assay has been widely applied. During this assay, although normalization of target genes against reference genes (RGs) has been indispensably conducted, the expression of RGs is also variable in each experimental condition which can result in false conclusion. Because the understanding for stable RG in porcine ovaries was still limited, we attempted to assess the stability of RGs from the pool of ten commonly used RGs (18S, B2M, PPIA, RPL4, SDHA, ACTB, GAPDH, HPRT1, YWHAZ, and TBP) in the porcine ovaries under different estrus phase (follicular and luteal phase) and cystic condition, using stable RG-finding programs (geNorm, Normfinder, and BestKeeper). The significant (p < 0.01) differences in Ct values of RGs in the porcine ovaries under different conditions were identified. In assessing the stability of RGs, three programs comprehensively agreed that TBP and YWHAZ were suitable RGs to study porcine ovaries under different conditions but ACTB and GAPDH were inappropriate RGs in this experimental condition. We hope that these results contribute to plan the experiment design in the field of reproductive physiology in pigs as reference data.
Chemisorption of Ethanol on Ge(100) Surface
Bae, Sung-Soo,Lee, A-Reum,Kim, Sehun,Kim, Do Hwan American Chemical Society 2018 The Journal of Physical Chemistry Part C Vol.122 No.27
<P>Chemical reaction of ethanol (CH<SUB>3</SUB>CH<SUB>2</SUB>OH) with Ge(100) surface has been investigated using scanning tunneling microscopy (STM) observation and density functional theory (DFT) calculations. At low coverage, high-resolution STM images showed that ethanol dissociatively adsorbed on a single Ge dimer. The adsorption features included bright protrusions assigned to Ge-OCH<SUB>2</SUB>CH<SUB>3</SUB> structure formed via O-H dissociation of ethanol. Real-time STM observations revealed that the molecular chain of ethanol increased gradually via successive adsorption along the dimer row direction following increased exposure to ethanol. DFT calculation results showed that the adsorption of ethanol on Ge(100) was dominated by kinetic control at room temperature. Thus, an integrated study of experimental and theoretical approaches coherently confirmed that ethanol reacts with Ge(100) via O-H dissociative adsorption and the final structure has the H-Ge-Ge-OCH<SUB>2</SUB>CH<SUB>3</SUB> geometry on a single dimer of Ge(100).</P> [FIG OMISSION]</BR>
Inhibitory Effect of Ginseng Polysaccharides on Rotavirus Infection
BAE, EUN-AH,SHIN, JI-EUN,PARK, SUNG-HWAN,KIM, DONG-HYUN 한국미생물 · 생명공학회 2004 Journal of microbiology and biotechnology Vol.14 No.1
Polysaccharides and saponins were isolated from the root of Panax ginseng C.A. Meyer (Family Araliaceae), treated at various temperatures, and their inhibitory effects on rotavirus were investigated. As the temperature of processing increased, the molecular weight of the polysaccharides decreased, but the yields of water extracted increased. These polysaccharides inhibited rotavirus infection in MA104 cells, but there were no significant differences in rotavirus infection-inhibitory potency. However, ginseng saponins did not exhibit rotavirus infection-inhibitory activity.
Bae, Kwang-HaK,Kim, Hyun-Duck,Jung, Se-Hwan,Park, Deok-Young,Paik, Dai-Il,Chung, Sung-Chang 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4
본 연구의 목적은 첫째, 55세이상성인을 대상으로 구강보건영향지수 중 물리적동통의 유병률을 파악하고, 둘째, 55세이상성인의 구강건강충격지수 중 물리적동통의 연관요인을 파악함에 있다. 조사대상자는 2000년 국민구강건강조사시 층화무작위추출법으로 표본추출된 4,250명의 55세이상성인집단 중에서 본 연구의 목적에 동의한 1,098명의 55세이상성인이었고, 조사방법은 전화면접조사법이었다. 면접문항은 구강건강충격지수 중 물리적동통에 관련된 9개의 문항와 성, 연령, 거주지역 및 의치장착여부등에 관한 4문항을 합하여 총 13문항이었고, 동통정도의 웅답은 5점리커트척도(0-4)룰 이용하여 기록되었다. 동통유병를은 동통정도 0-1을 동통무경험자로, 동통정도 2-4를 동통유경험자로 하였고, 총물리적동통정도(PPS)는 9개의 개별물리적동통정도의 합으로 최저 0점에서 최고 36점에 분포하도록 하였다. 동통유병률에 관한 연관요인을 파악하기 위하여 다변량 로지스틱회귀분석을 실시하였고, 총물리적동통정도에 관한 연관요인을 파악하기 위하여, 다변량 선형회귀분석을 실시하였다. 두통, 치은동통, 과민성치아 둥에 관한 유병률은 각각 6.8%, 17.2% 및 26.0% 이었다. 여자는 남자에서 보다 두통유병률의 가능성이 2.3배(95% 신뢰구간=1.33,3.99) 높았고, 치은동통유병률의 가능성은 1.4배(95% 신뢰구간=1.01, 1.97) 높았다. 국부의치장착자는 의치비장착자보다 치은동통유병률의 가능성이 1.8배(95% 신뢰구간=1.20, 2.58) 높았으며, 의치장착은 총물리적동통정도를 1.58 증가시겼다(확률값=0.001). 총괄적으로, 두통유병률과 과민성치아유병률의 연관요인은 성이었고, 치은동통유병률의 연관요인은 성과 의치장착이었다.
A New Mobile Watermarking Scheme Based on Display-capture
Bae, Jong-Wook,Jung, Sung-Hwan Korea Multimedia Society 2009 멀티미디어학회논문지 Vol.12 No.6
Most of existing watermarking schemes insert and extract a watermark, focusing on the visual conservation of an original image. However, existing watermarking schemes could be difficult for a watermark detection in case of various distortion caused by display-capture devices. Therefore, we propose a new display-capture based mobile watermarking scheme. The proposed watermarking scheme is a new concept for embedding a watermark, which uses the generated image instead of a given original image. For effective watermark decoding, we also present a method for detecting the background image whose error bit can not be corrected because of various heavy distortion and for avoiding it from the decoding process. For this scheme, we adopt distortion coefficients of camera calibration when we separate a background image from a captured image. For finding available correction bits of ECC through the decoding process, we capture 30,000 images and then calculate the separation ratio of a background image and the average error bits per an image. As experimental result, the separation ratio of a background image is about 96.5% in 30,000 captured image. And the false alarm ratio shows about $5.18{\times}10^{-4}$ in the separated background image. And also we can confirm the availability of real-time processing because the mean execution time is about 82ms per an image for capturing and decoding.