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A New Enhancer in the Flanking Region of the Gene Pou5f1
B. Debeb,B. Binas 한양대학교 이학기술연구소 2009 이학기술논문지 Vol.13 No.-
The gene Pou5f1 encodes the transcription factor Oct4 that is essential for establishing and maintaining pluripotency and may also be involved in early embryonic lineage decisions. It was previously shown that two different enhancers drive the transcription of Pou5f1 in pluripotent stem cells while an enhancer driving Pou5f1 in a non-pluripotent cell type has not yet been described. However, we recently found that Oct4 is expressed in non-pluripotent extraembryonic endoderm precursor (XEN-P) celll ines, and we therefore asked whether Pou5fl. uses a distinct enhancer in these cells. Here we describe reporter gene transfection experiments that indeed document the existence of a new enhancer driving Pou5f1 in the XEN-P cells. Our results reveal an additional regulation of Pou5f1 that may be related to non-traditional roles of Oct4.