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- 저자 : Axel Heimann (검색결과 1 건)
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Jonas F Schiemer,Axel Heimann,Karin H Somerlik-Fuchs,Roman Ruff,Klaus-Peter Hoffmann,Jan Baumgart,Manfred Berres,Hauke Lang,Werner Kneist 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.3
Background/AimsMotility disorders are common and may affect the entire gastrointestinal (GI) tract but current treatment is limited. Multilocularsensing of GI electrical activity and variable electrical stimulation (ES) is a promising option. The aim of our study is to investigate theeffects of adjustable ES on poststimulatory spike activities in 5 GI segments. MethodsSix acute porcine experiments were performed with direct ES by 4 ES parameter sets (30 seconds, 25 mA, 500 microseconds or1000 microseconds, 30 Hz or 130 Hz) applied through subserosal electrodes in the stomach, duodenum, ileum, jejunum, and colon. Multi-channel electromyography of baseline and post-stimulatory GI electrical activity were recorded for 3 minutes with hook needleand hook-wire electrodes. Spike activities were algorithmically calculated, visualized in a heat map, and tested for significance byPoisson analysis. ResultsPost-stimulatory spike activities were markedly increased in the stomach (7 of 24 test results), duodenum (8 of 24), jejunum (23 of24), ileum (18 of 24), and colon (5 of 24). ES parameter analysis revealed that 80.0% of the GI parts (all but duodenum) required apulse width of 1000 microseconds, and 60.0% (all but jejunum and colon) required 130 Hz frequency for maximum spike activity. Fivereaction patterns were distinguished, with 30.0% earlier responses (type I), 42.5% later or mixed type responses (type II, III, and X),and 27.5% non-significant responses (type 0). ConclusionsMultilocular ES with variable ES parameters is feasible and may significantly modulate GI electrical activity. Automatedelectromyography analysis revealed complex reaction patterns in the 5 examined GI segments.
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