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      저자 : Athena Christakos (검색결과 1 건)
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        Prophylactic Phenylephrine for Iatrogenic Priapism: A Pilot Study With Peyronie's Patients

        Pengbo Jiang,Athena Christakos,Mina Fam,Hossein Sadeghi-Nejad 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.10

        Purpose: Although penile duplex Doppler ultrasonography (PDDU) is a common andintegral procedure in a Peyronie’s disease workup, the intracavernosal injection of vasoactiveagents can carry a serious risk of priapism. Risk factors include young age, goodbaseline erectile function, and no coronary artery disease. In addition, patients withPeyronie’s disease undergoing PDDU in an outpatient setting are at increased risk giventhe inability to predict optimal dosing. The present study was conducted to providesupport for a standard protocol of early administration of phenylephrine in patientswith a sustained erection after diagnostic intracavernosal injection of vasoactiveagents to prevent the deleterious effects of iatrogenic priapism. Materials and Methods: This was a retrospective review of Peyronie’s disease patientswho received phenylephrine reversal after intracavernosal alprostadil (prostaglandinE1) administration to look at the priapism rate. Safety was determined on the basisof adverse events reported by subjects and efficacy was determined on the basis of therate of priapism following intervention. Results: Patients with Peyronie’s disease only had better hemodynamic values onPDDU than did patients with Peyronie’s disease and erectile dysfunction. All of thepatients receiving prophylactic phenylephrine had complete detumescence of erectionswithout adverse events, including no priapism cases. Conclusions: The reversal of erections with phenylephrine after intracavernosal injectionsof alprostadil to prevent iatrogenic priapism can be effective without increasedadverse effects.

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