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RISS 인기검색어
- 검색키워드
- 저자 : Askes, Harm (검색결과 6 건)
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Askes, H.,Sluys, L.J.,de Jong, B.B.C. Techno-Press 2001 Structural Engineering and Mechanics, An Int'l Jou Vol.12 No.5
Remeshing strategies are formulated for r-adaptive and h/r-adaptive analysis of crack propagation. The relocation of the nodes, which typifies r-adaptivity, is a very cheap method to optimise a given discretisation since the element connectivity remains unaltered. However, the applicability is limited. To further improve the finite element mesh, a combined h/r-adaptive method is proposed in which h-adaptivity is applied whenever r-adaptivity is not capable of further improving the discretisation. Two and three-dimensional examples are presented. It is shown that the r-adaptive approach can optimise a discretisation at minimal computational costs. Further, the combined h/r-adaptive approach improves the performance of a fully r-adaptive technique while the number of h-remeshings is reduced compared to a fully h-adaptive technique.
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Gradient Viscoplastic Modelling of Material Instabilities in Metals
Wang, W . M .,Askes, H .,Sluys, L . J . 대한금속재료학회(대한금속학회) 1998 METALS AND MATERIALS International Vol.4 No.3
A gradient viscoplasticity model has been used to analyse stationary and propagative instabilities. It is demonstrated that the use of viscous regularisation is effective for both quasistatic and dynamic problems. Due to the influence of the length scales that are introduced in the model, the numerical simulation gives mesh-objective results with a finite width and unique orientation of the shear band. The numerical simulation of shear banding and propagative Portevin-Le Chatelier bands will be discussed. A 3D analysis of shear banding is shown to give significantly different results than the 2D plane strain analysis under similar conditions. Very fine meshes are needed to obtain accurate solutions for the shear hand. The Arbitrary Lagrangian Eulerian remeshing method will be used to relocate elements from outside to inside the shear band to minimise computer costs.
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Calik-Karakose, Ulku H.,Orakdogen, Engin,Saygun, Ahmet I.,Askes, Harm Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.2
A four-noded curved shell finite element for the geometrically non-linear analysis of beams curved in plan is introduced. The structure is conceived as a sequence of macro-elements (ME) having the form of transversal segments of identical topology where each slice is formed using a number of the curved shell elements which have 7 degrees of freedom (DOF) per node. A curved box-girder beam example is modelled using various meshes and linear analysis results are compared to the solutions of a well-known computer program SAP2000. Linear and non-linear analyses of the beam under increasing uniformly distributed loads are also carried out. In addition to box-girder beams, the proposed element can also be used in modelling open-section beams with curved or straight axes and circular plates under radial compression. Buckling loads of a circular plate example are obtained for coarse and successively refined meshes and results are compared with each other. The advantage of this element is that curved systems can be realistically modelled and satisfactory results can be obtained even by using coarse meshes.
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Ü lkü H. Çalık-Karaköse,Engin Orakdöğen,Ahmet I. Saygun,Harm Askes 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.2
A four-noded curved shell finite element for the geometrically non-linear analysis of beams curved in plan is introduced. The structure is conceived as a sequence of macro-elements (ME) having the form of transversal segments of identical topology where each slice is formed using a number of the curved shell elements which have 7 degrees of freedom (DOF) per node. A curved box-girder beam example is modelled using various meshes and linear analysis results are compared to the solutions of a well-known computer program SAP2000. Linear and non-linear analyses of the beam under increasing uniformly distributed loads are also carried out. In addition to box-girder beams, the proposed element can also be usedin modelling open-section beams with curved or straight axes and circular plates under radial compression. Buckling loads of a circular plate example are obtained for coarse and successively refined meshes andresults are compared with each other. The advantage of this element is that curved systems can be realistically modelled and satisfactory results can be obtained even by using coarse meshes.
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GMM Rao,ChV Rao,M. Sudhakara,M M Pandey,ASK Rawat,A Sirwaikar,AB Joshi 한국생약학회 2004 Natural Product Sciences Vol.10 No.1
The fresh fruit juice powder of Coccinia indica W.&A., (Cucurbitaceae, CJP) was studied for the possible activities of antiinflammatory and antinociceptive to rationalize the folkloric use of the plant juice as rasayana. CJP at the doses of 50-200 mg/kg caused a significant (P<0.05 to P<0.001) inhibition of paw edema induced by λ carrageenin (1%) and histamine (10−3 g/ml, 0.1 ml) in rats. The effect was comparable to the standard cycloxygenase inhibitor brufen at 100 mg/kg and protective percentages were 63.41% and 65.78% respectively. Administration of CJP (50-200 mg/kg) exhibited a moderate increase of the pain threshold on analgesy-meter induced mechanical pain. However CJP significantly prevented the writhing induced by acetic acid in mice and the percentages of inhibitions were 16.98%-35.47%, which is equivalent to 36.67% produced by brufen. These data indicate that the fruit juice of Coccinia indica rationalizes the traditional system of medicine.
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Nocon, Justyna,Steiger, Matthias G.,Pfeffer, Martin,Sohn, Seung Bum,Kim, Tae Yong,Maurer, Michael,Rußmayer, Hannes,Pflü,gl, Stefan,Ask, Magnus,Haberhauer-Troyer, Christina,Ortmayr, Karin,Hann, Ste Academic Press 2014 Metabolic engineering Vol.24 No.-
<▼1><P>The production of recombinant proteins is frequently enhanced at the levels of transcription, codon usage, protein folding and secretion. Overproduction of heterologous proteins, however, also directly affects the primary metabolism of the producing cells. By incorporation of the production of a heterologous protein into a genome scale metabolic model of the yeast <I>Pichia pastoris</I>, the effects of overproduction were simulated and gene targets for deletion or overexpression for enhanced productivity were predicted. Overexpression targets were localized in the pentose phosphate pathway and the TCA cycle, while knockout targets were found in several branch points of glycolysis. Five out of 9 tested targets led to an enhanced production of cytosolic human superoxide dismutase (hSOD). Expression of bacterial β-glucuronidase could be enhanced as well by most of the same genetic modifications. Beneficial mutations were mainly related to reduction of the NADP/H pool and the deletion of fermentative pathways. Overexpression of the hSOD gene itself had a strong impact on intracellular fluxes, most of which changed in the same direction as predicted by the model. <I>In vivo</I> fluxes changed in the same direction as predicted to improve hSOD production. Genome scale metabolic modeling is shown to predict overexpression and deletion mutants which enhance recombinant protein production with high accuracy.</P></▼1><▼2><P><B>Highlights</B></P><P>•<P>Recombinant protein production in <I>P. pastoris</I> affects the central metabolism.</P>•<P>A genome scale metabolic model can predict these metabolic flux changes.</P>•<P>Mutations in central metabolic genes enhanced recombinant protein yield up to 40%.</P>•<P>These beneficial mutations were predicted by the metabolic model with high accuracy.</P></P></▼2>
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