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- 저자 : Arzu Sahin (검색결과 3 건)
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Koray Sahin,Fatih Senturk,Mehmet Ersin,Mechmet Chodza,Ufuk Arzu,Ali Ersen 대한견주관절의학회 2021 대한견주관절학회 학술대회논문집 Vol.2021 No.3
Introduction and Background Suture-bridge (SB) rotator cuff repair (RCR) is widely used due to its superior biomechanical and clinical outcomes. However, knot-tying SB technique has been suspected to compromise the tendinous biology and to cause strangulation and medial repair failures. Therefore, knotless SB technique has been proposed to decrease retear rates. The purpose of this study is to compare clinical, structural outcomes and retear patterns between two techniques Material and Method 104 patients with full-thickness rotator cuff tear were randomly and prospectively allocated to knot-tying (group I) or knotless (group II) SB surgeries. Clinical outcome measures included range of motion values, subjective pain scores (VAS) and functional scores (Constant score). Repair integrity was evaluated with magnetic resonance imagings using Sugaya classification. Retears were also classified according to their patterns as type 1 (lateral) and type 2 (medial). 88 patients completed the follow-up period and were included to final analysis. Results Mean age of patients was 54.3 years in group I and 55.8 years in group II. Mean follow-up period was 25.4 and 23.3 months respectively. Mean pain score of group I decreased from 7.4 to 1.0 (p<0.0001). The corresponding values for group II decreased from 7.1 to 1.3 (p<0.0001). In group I, mean Constant score increased from 51.7 to 86.0 (p<0.0001) and in group II, mean Constant score increased from 49.4 to 87.2 (p<0.0001). There was not statistically significant difference between two groups regarding post-operative pain and functional scores (p>0.05). Post-operative MR imaging revealed that the retear rate was 19.0% (8/42) in group I and 28.3% (13/46) in group II (p>0.05). Type 2 failure rate was 75.0% (6/8) in group I and 23.1% (3/13) in group II (p=0.03). Conclusions Both techniques showed excellent improvement and comparable clinical outcomes. However, there was no significant difference in retear rates between techniques. Type 2 failure rate was higher in knot-tying technique.
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Kargi, Aysegul,Bisgin, Atil,Yalcin, Arzu Didem,Kargi, Ahmet Bulent,Sahin, Emel,Gumuslu, Saadet Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
Background: Lung cancer is the leading cause of cancer mortality in the world. Many factors can protect against or facilitate its development. A TNF family member TRAIL, has a complex physiological role beyond that of merely activating the apoptotic pathway in cancer cells. Vitamin D is converted to its active form locally in the lung, and is also thought to play an important role in lung health. Our goal was to investigate the possible clinical significance of serum sTRAIL and 1,25-dihydroxyvitamin D(3) levels in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Totals of 18 consecutive adenocarcinoma and 22 squamous cell carcinoma patients with stage-IV non-small cell lung cancer referred to our institute were included in this study. There were 12 men and 6 women, with ages ranging from 38 to 97 (mean 60.5) years with adenocarcinoma, and 20 men and 2 women, with ages ranging from 46 to 80 (mean 65) years with squamous cell carcinoma. Serum levels of sTRAIL and 1,25-dihydroxyvitamin D(3) were measured in all samples at the time of diagnosis. Results: sTRAIL levels in NSCLC patients were higher than in the control group. Although there was no correlation between patient survival and sTRAIL levels, the highest sTRAIL levels were correlated with age and cigarette smoking in the adenocarcinoma patients. sTRAIL level in healthy individuals were correlated with serum 1,25-dihydroxyvitamin D(3). Conclusions: Serum sTRAIL concentrations were increased in NSCLC patients, and correlated with age and smoking history, but not with overall survival.
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Eda Dokumacioglu,Ozay Demiray,Ali Dokumacioglu,Arzu Sahin,Tugba Mazlum Sen,Soner Cankaya 대한비뇨의학회 2018 Investigative and Clinical Urology Vol.59 No.4
Purpose: In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation. Materials and Methods: A total of 90 women were included in the study: 45 female patients diagnosed with OAB at Hopa State Hospital Urology Polyclinic and 45 healthy women without any metabolic or neurologic disease. Levels of MDA and 8-OHdG were measured in 24-hour urine samples for all subjects. Results: Urinary levels of MDA and 8-OHdG were significantly higher in the OAB group than in the control group (p<0.001). A significant positive correlation (p<0.001) was found between the measurements of 8-OHdG and MDA. Conclusions: Oxidative stress may be important in the pathophysiology of OAB, because levels of 8-OHdG and MDA are increased. Increased levels of 8-OHdG may be due to damaged nuclear and mitochondrial DNA as a result of oxidative attacks caused by free radicals. Nevertheless, further randomized and prospective studies with larger patient populations are needed.
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