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Arundhati Baratam,Alice Mary Karlapudy,Suryakalavathi Munagala 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.4
This paper focuses on the analysis and compensation of thrust ripples in permanent magnet linear synchronous motors (PMLSM). The main drawback in PMLSMs is the presence of thrust ripples, which are mainly due to the interaction between the permanent magnets and armature slotted core. These thrust ripples reduce the performance of the drive system in high precision applications especially at low speeds. This paper analyzes thrust ripples using the discrete wavelet transform. These undesired thrust ripples are compensated by using an adaptive feed forward controller. It is observed that this novel controller reduces about 65 percent of the thrust ripples. An extensive simulation is performed through MATLAB and it is validated through experimental results using a d-SPACE system with a DS1104 control board.
GSTT1 Null Genotype Distribution in the Kumaun Region of Northern India
Bag, Arundhati,Upadhyay, Saloni,Jeena, Lalit M.,Pundir, Princi,Jyala, Narayan S. Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Glutathione S-transferases (GSTs) constitute a multigene family of multifunctional phase II metabolic enzymes. GSTT1, an important member of this group has a wide range of substrates including carcinogens. Total homozygous deletion or null genotype resulting in total lack of enzyme activity exists in populations for this enzyme. Since the null genotype may contribute to lower detoxification of carcinogens, this genotype is expected to increase cancer risk. The frequency of the GSTT1 null genotype is known to vary significantly among populations. However, little is known about its distribution in the hilly Kumaun region of northern India. Therefore, in this study, we determined the prevalence of the GSTT1 null polymorphism in the Kumaun popilation by conducting duplex PCR in 365 voluntary healthy individuals. The GSTT1 null genotype was detected in 18.4% of the individuals. Since GSTs play significant role in xenobiotic metabolism, the present data on GSTT1 genotype distribution should contribute in understanding genetic association with cancer risk in this understudied population.
GSTT1 null and MPO -463G>A Polymorphisms and Carboplatin Toxicity in an Indian Population
Bag, Arundhati,Pant, Nirdosh Kumar,Jeena, Lalit Mohan,Bag, Niladri,Jyala, Narayan Singh Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
Carboplatin, a second generation platinum drug, is widely used to treat different types of cancers. However, myelosuppression remains a major consideration in its use. Genetic polymorphisms of enzymes involved in drug disposition can influence therapeutic outcome. The homozygous null deletion of phase II metabolic gene GSTT1 that abolishes its xenobiotic- detoxifying ability may be associated with carboplatin toxicity. Further, since carboplatin generates oxidative stress, polymorphisms of oxidative stress genes that regulate the cellular level of free radicals may have important roles in generating drug- related adverse effects. We here investigated the null polymorphism of GSTT1, and the -463G>A promoter polymorphism of oxidative stress gene myeloperoxidase (MPO) for carboplatin toxicity in a population of northern India. Cancer patients who were treated with carboplatin, and developed toxicity was considered. The study group comprised of 10 patients who developed therapy- related adverse effects. Peripheral blood was taken from patients for DNA isolation. GSTT1 null genotype was determined by conducting duplex PCR and MPO-463 G>A was determined by PCR followed by RFLP. Hematologic toxicity was experienced by 5 patients, 2 of them had grade 3 and 4 toxicity and 3 others had grade 2 toxicity. They also had gastrointestinal (GI) toxicity. Remaining 5 individuals developed GI toxicity but no hematological toxicity. While GG homozygous of MPO was present in majority of patients having hematologic toxicity (in 4 out of 5 individuals), one A allele (AG genotype) was present in 4 patients who did not have any hematological toxicity. Thus variant A allele of MPO -463G>A may be related to lower hematological toxicity. These preliminary data, however, are required to be confirmed in larger studies along with other relevant polymorphisms.
Baratam, Arundhati,Karlapudy, Alice Mary,Munagala, Suryakalavathi The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.4
This paper focuses on the analysis and compensation of thrust ripples in permanent magnet linear synchronous motors (PMLSM). The main drawback in PMLSMs is the presence of thrust ripples, which are mainly due to the interaction between the permanent magnets and armature slotted core. These thrust ripples reduce the performance of the drive system in high precision applications especially at low speeds. This paper analyzes thrust ripples using the discrete wavelet transform. These undesired thrust ripples are compensated by using an adaptive feed forward controller. It is observed that this novel controller reduces about 65 percent of the thrust ripples. An extensive simulation is performed through MATLAB and it is validated through experimental results using a d-SPACE system with a DS1104 control board.
Devi, Prattipati Subhashini,Satyanarayana, Botcha,Arundhati, Atluru,Rao, Tamanam Raghava 한국작물학회 2014 Journal of crop science and biotechnology Vol.17 No.1
The present study is an attempt to prepare synthetic seeds using alginate encapsulation of nodal explants of Sterculia urens. Regeneration potential of encapsulated nodal segments was tested on MS basal, MS + BA ($3.0mg\;L^{-1}$), MS + TDZ ($0.2mg\;L^{-1}$), and MS + BA ($0.5mg\;L^{-1}$) + NAA ($2.0mg\;L^{-1}$). The regeneration potential was maximum ($73.33{\pm}1.33$) on MS + TDZ ($0.2mg\;L^{-1}$) followed by ($69.33{\pm}1.76$) on MS + BA ($3mg\;L^{-1}$) even after 6 months of storage at $4^{\circ}C$, whereas controls did not show any regeneration potential after 1 week. These findings suggest synthetic seed technology as an alternative method for micropropagation and germplasm conservation of Sterculia urens an endangered species.
P. Subhashini Devi,B. Satyanarayana,A. Arundhati,T. Raghava Rao 한국산림과학회 2012 Forest Science And Technology Vol.8 No.1
Sterculia urens is a commercially important tree with wide applications. Although it reproduces by seed, its germination requirements are not known. The seed also suffers with dormancy. The present study is an attempt to understand the proper storage conditions and also the type of dormancy in seeds of Sterculia urens. The optimum temperature for storage of seeds was found to be 0–4℃ in a polythene bag which retained the required moisture content of seed for germination. The treatment with phytohormones showed maximum increase in germination percentage followed by acid and mechanical scarification, suggesting both physical and physiological dormancy in seeds of Sterculia urens.
Prattipati Subhashini Devi,Botcha Satyanarayana,Atluru Arundhati,Tamanam Raghava Rao 한국작물학회 2014 Journal of crop science and biotechnology Vol.17 No.1
The present study is an attempt to prepare synthetic seeds using alginate encapsulation of nodal explants of Sterculia urens. Regeneration potential of encapsulated nodal segments was tested on MS basal, MS + BA (3.0 mg L-1), MS + TDZ (0.2 mg L-1), andMS + BA (0.5 mg L-1) + NAA (2.0 mg L-1). The regeneration potential was maximum (73.33 ± 1.33) on MS + TDZ (0.2 mg L-1) followedby (69.33 ± 1.76) on MS + BA (3 mg L-1) even after 6 months of storage at 4°C, whereas controls did not show any regenerationpotential after 1 week. These findings suggest synthetic seed technology as an alternative method for micropropagation andgermplasm conservation of Sterculia urens an endangered species.
Patel, Snahel,Cohen, Frederick,Dean, Brian J,De La Torre, Kelly,Deshmukh, Gauri,Estrada, Anthony A,Ghosh, Arundhati Sengupta,Gibbons, Paul,Gustafson, Amy,Huestis, Malcolm P,Le Pichon, Claire E,Lin, Ha American Chemical Society 2015 Journal of medicinal chemistry Vol.58 No.1
<P>Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the generation of potent and selective DLK inhibitors starting from a high-throughput screening hit. Using proposed hinge-binding interactions to infer a binding mode and specific design parameters to optimize for CNS druglike molecules, we came to focus on the di(pyridin-2-yl)amines because of their combination of desirable potency and good brain penetration following oral dosing. Our lead inhibitor GNE-3511 (26) displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. These results suggest that specific pharmacological inhibition of DLK may have therapeutic potential in multiple indications.</P>