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Revealing an unusual transparent phase of superhard iron tetraboride under high pressure
Kotmool, Komsilp,Kaewmaraya, Thanayut,Chakraborty, Sudip,Anversa, Jonas,Bovornratanaraks, Thiti,Luo, Wei,Gou, Huiyang,Piquini, Paulo Cesar,Kang, Tae Won,Mao, Ho-kwang,Ahuja, Rajeev National Academy of Sciences 2014 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.111 No.48
<P><B>Significance</B></P><P>Solids have been mainly studied at ambient conditions (i.e., at room temperature and zero pressure). However, it was realized early that there is also a fundamental relation between volume and structure and that this dependence could be most fruitfully studied by means of high-pressure experimental techniques. From a theoretical point of view this is an ideal type of experiment, because only the volume is changed, which is a very clean variation of the external conditions. In the present study we show a hard superconducting material, iron tetraboride, transforms into a novel transparent phase under pressure. Further, this phase is the first system in this class, to our knowledge, and opens a new route to search for and design new transparent materials.</P><P>First principles–based electronic structure calculations of superhard iron tetraboride (FeB<SUB>4</SUB>) under high pressure have been undertaken in this study. Starting with a “conventional” superconducting phase of this material under high pressure leads to an unexpected phase transition toward a semiconducting one. This transition occurred at 53.7 GPa, and this pressure acts as a demarcation between two distinct crystal symmetries, metallic orthorhombic and semiconducting tetragonal phases, with <I>Pnnm</I> and <I>I</I>4<SUB>1</SUB>/<I>acd</I> space groups, respectively. In this work, the electron–phonon coupling-derived superconducting T<SUB><I>c</I></SUB> has been determined up to 60 GPa and along with optical band gap variation with increasing pressure up to 300 GPa. The dynamic stability has been confirmed by phonon dispersion calculations throughout this study.</P>
Disruption of Striated Preferentially Expressed Gene Locus Leads to Dilated Cardiomyopathy in Mice
Liu, Xiaoli,Ramjiganesh, Tripurasundari,Chen, Yen-Hsu,Chung, Su Wol,Hall, Sean R.,Schissel, Scott L.,Padera Jr, Robert F.,Liao, Ronglih,Ackerman, Kate G.,Kajstura, Jan,Leri, Annarosa,Anversa, Piero,Ye Ovid Technologies Wolters Kluwer -American Heart A 2009 CIRCULATION - Vol.119 No.2
<P>BACKGROUND: The striated preferentially expressed gene (Speg) generates 4 different isoforms through alternative promoter use and tissue-specific splicing. Depending on the cell type, Speg isoforms may serve as markers of striated or smooth muscle differentiation. METHODS AND RESULTS: To elucidate function of Speg gene isoforms, we disrupted the Speg gene locus in mice by replacing common exons 8, 9, and 10 with a lacZ gene. beta-Galactosidase activity was detected in cardiomyocytes of the developing heart starting at day 11.5 days post coitum (dpc). beta-Galactosidase activity in other cell types, including vascular smooth muscle cells, did not begin until 18.5 dpc. In the developing heart, protein expression of only Spegalpha and Spegbeta isoforms was present in cardiomyocytes. Homozygous Speg mutant hearts began to enlarge by 16.5 dpc, and by 18.5 dpc, they demonstrated dilation of right and left atria and ventricles. These cardiac abnormalities in the absence of Speg were associated with a cellular hypertrophic response, myofibril degeneration, and a marked decrease in cardiac function. Moreover, Speg mutant mice exhibited significant neonatal mortality, with increased death occurring by 2 days after birth. CONCLUSIONS: These findings demonstrate that mutation of the Speg locus leads to cardiac dysfunction and a phenotype consistent with a dilated cardiomyopathy.</P>