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- 저자 : Antonia Barcelo (검색결과 1 건)
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Santiago Tofé,Iñaki Argüelles,Guillermo Serra,Honorato García,Antonia Barcelo,Vicente Pereg 대한갑상선학회 2020 International Journal of Thyroidology Vol.13 No.2
Background and Objectives: Neck recurrences of thyroid cancer are frequently detected in routine ultrasound (US)follow-up. Broad management of these lesions may include active surveillance, surgery or local percutaneoustechniques, but for the latter, little is known about impact on long-term follow-up and need of subsequentradioactive iodine (RAI) therapy. Materials and Methods: 42 patients underwent US-guided ethanol ablation (EA)over 71 thyroid bed or lymph node confirmed recurrences. All volume reduction >50%, absence of power Dopplersignal and fine needle aspiration (FNA) washout thyroglobulin (Tg) value <1 ng/mL should be present to considera complete ablation. Patients with TNM stage I-II, ≤2 lesions and/or baseline plasma TSH-suppressed Tg level <0.2ng/mL did not undergo post-EA RAI therapy. Post-EA plasma Tg values were compared to baseline in patientswith and without subsequent RAI therapy. Results: 62 lesions (87.32%) achieved a complete ablation after a meanfollow-up of 40.5 months (range, 12-73). Four treated lesions (5.63%) recurred (3/39 and 1/32 in patients withand without subsequent RAI therapy), and 7 patients (16.66%) developed new recurrences throughout follow-up(5/19 and 2/23 with and without RAI therapy). Both plasma TSH-suppressed and TSH-stimulated Tg levelsdescended after EA in both groups, and 17/38 (44.73%) patients achieved a TSH-suppressed Tg <0.2 ng/mL,with no differences between both groups of patients. All EA procedures were conducted safely without seriousor persistent side effects. Conclusion: Successful EA were achieved safely in 87.32% of patients with recurrentthyroid cancer, with a positive effect on systemic disease as reflected by plasma post-EA Tg levels. A subset ofpatients with TNM stage III, ≤2 lesions and/or low pre-EA plasma Tg levels may not need subsequent RAI therapyafter successful ablation. Overall, EA is an effective and balanced therapy for selected patients with neck recurrentthyroid cancer as an alternative to surgery.
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