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        DISCOVERY OF A STRONG LENSING GALAXY EMBEDDED IN A CLUSTER AT z = 1.62

        WONG, KENNETH C.,TRAN, KIM-VY H.,SUYU, SHERRY H.,MOMCHEVA, IVELINA G.,BRAMMER, GABRIEL B.,BRODWIN, MARK,GONZALEZ, ANTHONY H.,HALKOLA, ALEKSI,KACPRZAK, GLENN G.,KOEKEMOER, ANTON M.,PAPOVICH, CASEY J.,R The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

        We identify a strong lensing galaxy in the cluster IRC 0218 that is spectroscopically confirmed to be at z = 1.62, making it the highest-redshift strong lens galaxy known. The lens is one of the two brightest cluster galaxies and lenses a background source galaxy into an arc and a counterimage. With Hubble Space Telescope (HST) grism and Keck/LRIS spectroscopy, we measure the source redshift to be $z_S=2.26$. Using HST imaging, we model the lens mass distribution with an elliptical power-law profile and account for the effects of the cluster halo and nearby galaxies. The Einstein radius is $^{\theta}E=0.38^{+0.02{\prime}{\prime}}_{-0.01}$ ($3.2^{+0.2}_{-0.1}kpc$) and the total enclosed mass is $M_{tot}(<^{\theta}_E)=1.8^{+0.2}_{-0.1}{\times}10^{11}M_{\odot}$. We estimate that the cluster environment contributes ~ 10% of this total mass. Assuming a Chabrier IMF, the dark matter fraction within $^{\theta}E$ is $f^{Chab}_{DM}=0.3^{+0.1}_{-0.3}$, while a Salpeter IMF is marginally inconsistent with the enclosed mass ($f^{Salp}_{DM}=-0.3^{+0.2}_{-0.5}$).

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        Molecular risk classifier score and biochemical recurrence risk are associated with cribriform pattern type in Gleason 3+4=7 prostate cancer

        Nancy Y. Greenland,Matthew R. Cooperberg,Anthony C. Wong,Emily Chan,Peter R. Carroll,Jeffry P. Simko,Bradley A. Stohr 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.1

        Purpose: Among Gleason pattern 4 types, cribriform pattern is associated with the worst outcomes. We hypothesized that larger cribriform patterns would be associated with increased Decipher scores and higher biochemical recurrence (BCR) risk in Gleason 3+4=7 prostatectomy patients. Materials and Methods: The slide from patients who underwent prostatectomy from January 2016 to March 2020 on which Decipher was performed was re-reviewed for Gleason score and cribriform patterns, with large cribriform defined as cribriform acini with greater than 12 lumens and simple cribriform as 12 or fewer lumens. Differences in Decipher score were analyzed in a generalized linear model controlling for pathology stage and tumor margin status. A multivariable Cox proportional hazards model was performed for BCR-free survival. Results: Of 337 cases, 118 were Gleason 3+4=7. The mean Decipher scores in 3+4=7 cases without cribriform, with simple cribriform, and with large cribriform were 0.41, 0.54, and 0.62, respectively. In a multivariable model with pathology stage, margin tumor length, and percentage pattern 4 as covariates, compared to cases without cribriform, simple cribriform was associated with 0.10 increase in Decipher (p=0.03) and 4.7-fold hazard ratio of BCR (95% confidence interval [CI], 0.4–56.5; p=0.22) and large cribriform was associated with 0.17 increase in Decipher (p<0.001) and 16.0-fold hazard ratio of BCR (95% CI, 1.4–181.2; p=0.02). Conclusions: Among Gleason 3+4=7 carcinomas, large cribriform was associated with higher Decipher scores and greater BCR risk. Our results support that large cribriform is an aggressive pattern 4 subtype and should be considered a contraindication for active surveillance.

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