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      • Optimal Placement of SVC Incorporating Installation Cost

        Ankit Kumar Sharma,Akash Saxena,Rajive Tiwari 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.8

        As the FACTS controllers are an inequitable part of power system due to their fast and very flexible control. With the enhancement of FACTS technology, their role in the marginal cost determination should be considered taking their cost function into account. The aim of this paper is to compare the optimal performance of static VAR compensator (SVC) in voltage stability enhancement problem. During last decade, FACTS devices are broadly used for maximizing the margin of voltage stability and loadability of existing power system transmission networks. To get the optimal system, cost analysis might be necessary. In the cost analysis of SVC, authors analyzed the installation cost of SVC devices in USD, the cost of SVC in USD/KVAR and the average value of installation cost for given systems. Here, the voltage stability enhancement problem is solved applying Gravitational Search algorithm incorporating SVC. The following conditions are investigated with the incorporation of SVC: the role of SVC for improving the voltage profile, loss minimization and the approximate analysis on cost recovery and payback period with SVC in voltage stability enhancement problem. With this motivation, the location of SVC is finalized through weak bus identification methods. Voltage stability indices namely Fast Voltage Stability Index (FVSI) is utilized to identify weak buses in the systems. For calculation of the Size of SVC, an optimization routine Gravitational Search Algorithm (GSA) is established. The main purpose of optimization is to minimize the FVSI. The proposed approach has been tested on three standard IEEE bus systems with different loading scenarios. General Terms: Flexible AC Transmission System (FACTS), Marginal Cost, Voltage Stability Assessment, Static VAR Compensators.

      • Exploratory Study to Evaluate Changes in Serum Lipid Levels as Early Diagnostic and/or Prognostic Indicators for Oral Submucous Fibrosis and Cancer among Gutkha Consumers in India

        Agarwal, Ankit,Saxena, Anshul,Rubens, Muni,Ahuja, Rinky,Tijare, Manisha Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

        Background: In India smokeless tobacco users account for 25.9% of total tobacco use, Gutkha being the most common form. This study evaluated the association between serum lipid profile and Gutkha use as an early diagnostic and/or prognostic indicator for oral submucous fibrosis (OSMF) and oral cancer (Oral Ca) in non-smokers and non-alcohol consumers. Materials and Methods: A total of 163 participants were recruited from two sites in India. Participants were divided into four groups: individuals without any Gutkha chewing habit and without any oral lesions (control group), individuals with Gutkha chewing habit but without any oral lesions (GWL), patients with a confirmed clinical diagnosis of OSMF, and patients with a confirmed diagnosis of Oral Ca. Mixed linear modelling (MLM) was conducted to detect the change in mean serum lipid levels among four groups. Results: The sample consisted of 69% males and 31% females. Results of MLM show an inverse relationship between serum lipid levels in OSMF, and Oral Ca groups when compared to the control group. Conclusions: The results of our study demonstrated that GWL, OSMF and Oral Ca patients had lower serum lipid levels. Low serum lipid levels could be an indicator of initial neoplastic changes in oral cancer.

      • SCOPUSKCI등재

        Association of Intracellular $T_H1-T_H2$ Balance in CD4+ T-cells and MIP-$1{\alpha}$ in CD8+ T-cells with Disease Severity in Adults with Dengue

        Kadhiravan, Tamilarasu,Saxena, Ankit,Singh, Amar,Broor, Shobha,Sharma, Surendra K.,Mitra, Dipendra K. The Korean Association of Immunobiologists 2010 Immune Network Vol.10 No.5

        Background: We tested the hypothesis that dengue haemorrhagic fever (DHF) is associated with a $T_H1$-skewed immune response as opposed to dengue fever (DF). Methods: We estimated intracellular (in T-cells) and serum levels of designate $T_H1/T_H2$ cytokines [interferon-${\gamma}$ (IFN-${\gamma}$), interleukin-4 (IL-4), and tumor necrosis factor-${\alpha}$] and macrophage inflammatory protein-$1{\alpha}$ (MIP-$1{\alpha}$) at admission, 48h, and day 5 in 20 adults with dengue (DF=10, DHF=10) and 10 dengue-naive healthy controls. Results: At admission, intracellular IFN-${\gamma}$/IL-4 ratio in CD4+ T-cells and proportion of MIP-$1{\alpha}$-positive CD8+ T-cells were significantly higher in patients with DHF [7.21 (5.36~10.81) vs. 3.04 (1.75~4.02); p=0.011 and 6.2% (3.2~8.2%) vs. 2.4% (2.0~3.6%); p=0.023]. The latter showed a significant positive correlation with IFN-${\gamma}$/IL-4 ratio in CD4+ T-cells (Spearman's rho=0.64; p=0.003), percentage-change in haematocrit (rho=0.47; p=0.048), and serum alanine amino-transferase level (rho=0.61; p=0.009). Conclusion: We conclude that DHF is associated with a $T_H1$-skewed immune response. Further, MIP-$1{\alpha}$ in CD8+ T-cells is an important immunologic correlate of disease severity in dengue.

      • SCOPUSKCI등재

        Association of Intracellular T<sub>H</sub>1-T<sub>H</sub>2 Balance in CD4+ T-cells and MIP-1α in CD8+ T-cells with Disease Severity in Adults with Dengue

        Kadhiravan, Tamilarasu,Saxena, Ankit,Singh, Amar,Broor, Shobha,Sharma, Surendra K.,Mitra, Dipendra K. 대한면역학회 2010 Immune Network Vol.10 No.5

        We tested the hypothesis that dengue haemorrhagic fever (DHF) is associated with a T<sub>H</sub>1-skewed immune response as opposed to dengue fever (DF). Methods: We estimated intracellular (in T-cells) and serum levels of designate T<sub>H</sub>1/T<sub>H</sub>2 cytokines [interferon-γ (IFN-γ), interleukin-4 (IL-4), and tumor necrosis factor-α] and macrophage inflammatory protein-1α (MIP-1α) at admission, 48h, and day 5 in 20 adults with dengue (DF=10, DHF=10) and 10 dengue-naive healthy controls. Results: At admission, intracellular IFN-γ/IL-4 ratio in CD4+ T-cells and proportion of MIP-1α-positive CD8+ T-cells were significantly higher in patients with DHF [7.21 (5.36~10.81) vs. 3.04 (1.75~4.02); p=0.011 and 6.2% (3.2~8.2%) vs. 2.4% (2.0~3.6%); p=0.023]. The latter showed a significant positive correlation with IFN-γ/IL-4 ratio in CD4+ T-cells (Spearman's rho=0.64; p=0.003), percentage-change in haematocrit (rho=0.47; p=0.048), and serum alanine amino-transferase level (rho=0.61; p=0.009). Conclusion: We conclude that DHF is associated with a T<sub>H</sub>1-skewed immune response. Further, MIP-1α in CD8+ T-cells is an important immunologic correlate of disease severity in dengue.

      • KCI등재

        Association of Intracellular TH1-TH2 Balance in CD4+ T-cells and MIP-1α in CD8+ T-cells with Disease Severity in Adults with Dengue

        Dipendra K. Mitra,Surendra K. Sharma,Tamilarasu Kadhiravan,Ankit Saxena,Amar Singh,Shobha Broor 대한면역학회 2010 Immune Network Vol.10 No.5

        We tested the hypothesis that dengue haemorrhagic fever (DHF) is associated with a TH1-skewed immune response as opposed to dengue fever (DF). Methods: We estimated intracellular (in T-cells) and serum levels of designate TH1/TH2 cytokines [interferon-γ (IFN-γ), interleukin-4 (IL-4), and tumor necrosis factor-α] and macrophage inflammatory protein-1α (MIP-1α) at admission, 48h, and day 5 in 20 adults with dengue (DF=10, DHF=10)and 10 dengue-naïve healthy controls. Results: At admission,intracellular IFN-γ/IL-4 ratio in CD4+ T-cells and proportion of MIP-1α-positive CD8+ T-cells were significantly higher in patients with DHF [7.21 (5.36∼10.81) vs. 3.04(1.75∼4.02); p=0.011 and 6.2% (3.2∼8.2%) vs. 2.4%(2.0∼3.6%); p=0.023]. The latter showed a significant positive correlation with IFN-γ/IL-4 ratio in CD4+ T-cells (Spearman’s rho=0.64; p=0.003), percentage-change in haematocrit (rho=0.47; p=0.048), and serum alanine aminotransferase level (rho=0.61; p=0.009). Conclusion: We conclude that DHF is associated with a TH1-skewed immune response. Further, MIP-1α in CD8+ T-cells is an important immunologic correlate of disease severity in dengue.

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