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Switching Model Predictive Control of a Pneumatic Artificial Muscle
George Andrikopoulos,George Nikolakopoulos,Ioannis Arvanitakis,Stamatis Manesis 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.6
In this article, a switching Model Predictive Controller (sMPC) scheme for the position control of a Pneumatic Artificial Muscle (PAM) is being presented. The control scheme is based on a constrained linear and PieceWise Affine (PWA) system model approximation that is able to capture the high nonlinearities of the PAM and improve the overall model accuracy, and is composed of: a) a feed-forward term regulating control input at specific reference set-points, and b) a switching Model Predic-tive Controller handling any deviations from the system’s equilibrium points. Extended simulation studies were utilized in order to investigate and evaluate the efficacy of the suggested controller in the positioning problem of a PAM.
Nikolaos K. Andrikopoulos,Andriana C. Kaliora,Andreana N. Assimopoulou,Vassilios P. Papageorgiou 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.1
The minor polyphenolic and nonpolyphenolic constituents of olive oil were examined, in var-ious doses, against copper ion induced low-density lipoprotein (LDL) oxidation and werefound, in optimal doses (final concentration, 10 mM or 20 mM), to have remarkable biologi-cal activity, contributing to that previously reported for the major phenolic compounds. Themain phytosterols, b-sitosterol, campesterol, and stigmasterol, were found to have 43.8%,37.3%, and 3.4% LDL mean protection (MP) activity, respectively, while free cholesterol ex-hibited 43.2% MP. The triterpenoid derivative compounds, ursolic acid, uvaol, and oleanolicacid, had similar MP activities of 50.5%, 46.8%, and 46.0%, respectively. Tocopherol (Toc) iso-mers exhibited an increasing effect in the following order: a-Toc (33.6%) , b-Toc (36.1%) ,g-Toc (42.9%) , d-Toc (46.0%). The flavonoid polyphenols, quercetin, luteolin, and rutin, ex-hibited the highest activities 46.8%, 49.5%, and 53.7% MP, respectively, comparable to the49.0% MP activity found for oleuropein. These findings indicate the relative independenceof LDL protection activity in regard to structural differences among the involved compounds.A relation to the Mediterranean diet is also demonstrated.
Aristea Gioxari,Andriana C. Kaliora,Apostolos Papalois,George Agrogiannis,John K. Triantafillidis,Nikolaos K. Andrikopoulos 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.11
Mastic (Pistacia lentiscus) of the Anacardiaceae family has exhibited anti-inflammatory and antioxidant properties in patients with Crohn's disease. This study was based on the hypothesis that mastic inhibits intestinal damage in inflammatory bowel disease, regulating inflammation and oxidative stress in intestinal epithelium. Four different dosages of P. lentiscus powder in the form of powder were administered orally to trinitrobenzene sulfonic acid–induced colitic rats. Eighty-four male Wistar rats were randomly assigned to seven groups: A, control; B, colitic; C–F, colitic rats daily supplemented with P. lentiscus powder at (C) 50 mg/kg, (D) 100 mg/kg, (E) 200 mg/kg, and (F) 300 mg/kg of body weight; and G, colitic rats treated daily with cortisone (25 μg/kg of body weight). Colonic damage was assessed microscopically. The cytokines tumor necrosis factor-α, intercellular adhesion molecule-1 (ICAM-1), interleukin (IL)-6, IL-8, and IL-10 and malonaldehyde were measured in colonic specimens. Results were expressed as mean±SE values. Histological amelioration of colitis (P≤.001) and significant differences in colonic indices occurred after 3 days of treatment. Daily administration of 100 mg of P. lentiscus powder/kg of body weight decreased all inflammatory cytokines (P≤.05), whereas 50 mg of P. lentiscus powder/kg of body weight and cortisone treatment reduced only ICAM-1 (P≤.05 and P≤.01, respectively). Malonaldehyde was significantly suppressed in all treated groups (P≤.01). IL-10 remained unchanged. Cytokines and malonaldehyde remained unaltered after 6 days of treatment. Thus P. lentiscus powder could possibly have a therapeutic role in Crohn's disease, regulating oxidant/antioxidant balance and modulating inflammation.
Apostolos Papalois,Aristea Gioxari,Andriana C. Kaliora,Aikaterini Lymperopoulou,George Agrogiannis,Efstathia Papada,Nikolaos K. Andrikopoulos 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.11
The Pistacia lentiscus tree gives a resinous exudate called Chios mastic (CM) rich in triterpenoids. CM can be fractionated into acidic and neutral fractions (AF and NF, respectively). Oleanolic acid (OA) is a major triterpenic acid in CM with several antioxidant and anti-inflammatory properties. We have recently shown that CM is beneficial in experimental colitis in the form of powder mixture with inulin, as supplied commercially. However, the bioactive fraction or compound of CM is unidentified. Thus, based on the hypothesis that terpenoids exhibit functional activities via distinguishable pathways, we fractionated CM and applied different fractions or individual OA in experimental colitis. Furthermore, we investigated the mechanism underlying this effect in human colon epithelial cells. CM powder mixture (100 mg/kg of body weight) or the respective CM powder mixture components (i.e., inulin, AF, NF, or OA) were individually administered in trinitrobenzene sulfonic acid-treated rats. Colonic damage was assessed microscopically, and levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-8, and intercellular adhesion molecule-1were measured. A model of inflammation in co-cultured human colon epithelial HT29 cells and monocytes/macrophages was established. Lactate dehydrogenase release and levels of TNF-α, IL-8, and nuclear factor-κB (NF-κB) p65 were measured. In vivo, histological amelioration of colitis and significant regulation in inflammation occurred with CM powder mixture, even at the mRNA level. Although no histological improvement was observed, AF and NF reduced levels of inflammatory markers. Inulin was ineffective. In vitro, CM treatment down-regulated IL-8 and NF-κB p65. Neither fractions nor OA was the bioactive component solely. Most probably, the entire CM rather than its individual fractions reduces inflammation via NF-κB regulation.