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Lateral pterygoid muscle volume and migraine in patients with temporomandibular disorders
Sérgio Lúcio Pereira de Castro Lopes,André Luiz Ferreira Costa,Thiago de Oliveira Gamba,Isadora Luana Flores,Adriana Dibo Cruz,Li Li Min 대한영상치의학회 2015 Imaging Science in Dentistry Vol.45 No.1
Purpose: Lateral pterygoid muscle (LPM) plays an important role in jaw movement and has been implicated in Temporomandibular disorders (TMDs). Migraine has been described as a common symptom in patients with TMDs and may be related to muscle hyperactivity. This study aimed to compare LPM volume in individuals with and without migraine, using segmentation of the LPM in magnetic resonance (MR) imaging of the TMJ. Materials and Methods: Twenty patients with migraine and 20 volunteers without migraine underwent a clinical examination of the TMJ, according to the Research Diagnostic Criteria for TMDs. MR imaging was performed and the LPM was segmented using the ITK-SNAP 1.4.1 software, which calculates the volume of each segmented structure in voxels per cubic millimeter. The chi-squared test and the Fisher’s exact test were used to relate the TMD variables obtained from the MR images and clinical examinations to the presence of migraine. Logistic binary regression was used to determine the importance of each factor for predicting the presence of a migraine headache. Results: Patients with TMDs and migraine tended to have hypertrophy of the LPM (58.7%). In addition, abnormal mandibular movements (61.2%) and disc displacement (70.0%) were found to be the most common signs in patients with TMDs and migraine. Conclusion: In patients with TMDs and simultaneous migraine, the LPM tends to be hypertrophic. LPM segmentation on MR imaging may be an alternative method to study this muscle in such patients because the hypertrophic LPM is not always palpable.
Identification of Secreted Virulence Factors of Chromobacterium violaceum
Thiago Castro-Gomes,Santuza M. R. Teixeira,Mariana S. Cardoso,Wanderson D. DaRocha,Letícia A. Laibida,Andréa M. A. Nascimento,Luciana W. Zuccherato,Maria Fátima Horta,Marcelo P. Bemquerer 한국미생물학회 2014 The journal of microbiology Vol.52 No.4
Chromobacterium violaceum, a component of tropical soilmicrobiota, is an opportunistic pathogenic bacterium thatcan infect humans and other animals. In addition to identifyinga large number of genes that demonstrate the vast biotechnologicalpotential of this bacterium, genome sequencingrevealed several virulence factors, including different cytolysins,which can be related to its pathogenicity. Here weconfirmed these predictions from genomic analyses by identifying,through mass spectrometry, proteins present in theculture supernatant of C. violaceum that may constitute secretedvirulence factors. Among them, we identified a secretedcollagenase and the product of a gene with sequence similarityto previously characterized bacterial porins.
Costa Andre Luiz Ferreira,Fardim Karolina Aparecida Castilho,Ribeiro Isabela Teixeira,Jardini Maria Aparecida Neves,Braz-Silva Paulo Henrique,Orhan Kaan,de Castro Lopes Sérgio Lúcio Pereira 대한영상치의학회 2023 Imaging Science in Dentistry Vol.53 No.1
Purpose: This study aimed to assess texture analysis (TA) of cone-beam computed tomography (CBCT) images as a quantitative tool for the differential diagnosis of odontogenic and non-odontogenic maxillary sinusitis (OS and NOS, respectively). Materials and Methods: CBCT images of 40 patients diagnosed with OS (N = 20) and NOS (N = 20) were evaluated. The gray level co-occurrence (GLCM) matrix parameters, and gray level run length matrix texture (GLRLM) parameters were extracted using manually placed regions of interest on lesion images. Seven texture parameters were calculated using GLCM and 4 parameters using GLRLM. The Mann-Whitney test was used for comparisons between the groups, and the Levene test was performed to confirm the homogeneity of variance (α = 5%). Results: The results showed statistically significant differences (P<0.05) between the OS and NOS patients regarding 3 TA parameters. NOS patients presented higher values for contrast, while OS patients presented higher values for correlation and inverse difference moment. Greater textural homogeneity was observed in the OS patients than in the NOS patients, with statistically significant differences in standard deviations between the groups for correlation, sum of squares, sum of entropy, and entropy. Conclusion: TA enabled quantitative differentiation between OS and NOS on CBCT images by using the parameters of contrast, correlation, and inverse difference moment.
Queiroz Polyane Mazucatto,Fardim Karolina Castilho,Costa André Luiz Ferreira,Matheus Ricardo Alves,Lopes Sérgio Lúcio Pereira Castro 대한영상치의학회 2023 Imaging Science in Dentistry Vol.53 No.2
Purpose: The aim of this study was to evaluate changes in the trabecular bone through texture analysis and compare the texture analysis characteristics of different areas in patients with medication-related osteonecrosis of the jaw (MRONJ). Materials and Methods: Cone-beam computed tomographic images of 16 patients diagnosed with MRONJ were used. In sagittal images, 3 regions were chosen: active osteonecrosis (AO); intermediate tissue (IT), which presented a zone of apparently healthy tissue adjacent to the AO area; and healthy bone tissue (HT) (control area). Texture analysis was performed evaluating 7 parameters: secondary angular momentum, contrast, correlation, sum of squares, inverse moment of difference, sum of entropies, and entropy. Data were analyzed using the Kruskal-Wallis test with a significance level of 5%. Results: Comparing the areas of AO, IT, and HT, significant differences (P<0.05) were observed. The IT and AO area images showed higher values for parameters such as contrast, entropy, and secondary angular momentum than the HT area, indicating greater disorder in these tissues. Conclusion: Through texture analysis, changes in the bone pattern could be observed in areas of osteonecrosis. The texture analysis demonstrated that areas visually identified and classified as IT still had necrotic tissue, thereby increasing the accuracy of delimiting the real extension of MRONJ.
Rheological behavior of blood in Wistar rats with different total cholesterol levels
Medina-Torres Luis,Calderas Fausto,Calderas Fausto,Núñez–Ramírez Diola-Marina,Castro Andrés Navarrete,Bernad-Bernad Ma. Josefa,Manero Octavio 한국유변학회 2022 Korea-Australia rheology journal Vol.34 No.4
Blood is a rheologically complex suspension, in which the soluble fraction contains proteins, total cholesterol and triglycerides. The blood rheological behavior is strongly affected by the concentration of these components. This work evaluates the total cholesterol effect on the rheological behavior of Wistar rat blood by means of an in vitro study. Twenty-one rats were divided into 3 groups, each one had an assigned diet with different fat content: reference group (RG) with 3%, medium fat content group (MG) with 4.5% and high-fat content group (HG) with 6.5%; in the latter group, mixed-vegetable fat was added. From each group, intraocular representative blood samples were taken with time lapse of 15 days between each sampling followed by biochemical and hemo-rheological tests. The first analysis detected changes in total cholesterol levels, attributed to the rat metabolism, formation of adipose tissue and competition for food. The second test consisted in steady simple-shear and linear oscillatory flow. The linear viscoelastic spectra reveal that the viscous modulus is larger than the elastic modulus (G > G′), with simple-shear viscosity exhibiting shear-thinning behavior. An important finding is a pseudo-solid- like behavior at low frequencies (1 rad/s) akin to the presence of yield stresses in the high-fat content group after 30 days, revealing strong interactions between total cholesterol levels and blood cells. The hemo-rheological tests represent a promising alternative to identify pathologies present in the blood (total cholesterol, digestive problems, and diabetes).
Paola Perez,Jaime Patiño,Alexis A. Franco,Fernando Rosso,Estefania Beltran,Eliana Manzi,Andrés Castro,Mayra Estacio,Diego Medina Valencia 대한혈액학회 2022 Blood Research Vol.57 No.1
Background Antifungal prophylaxis is recommended for hematopoietic stem cell transplantation (HSCT) to decrease the incidence of invasive fungal infections (IFI). This study aimed to compare the two groups of antifungal prophylaxis in pediatric patients undergoing allogeneic HSCT. Methods This observational, analytic, retrospective cohort study compared the incidence of IFI with antifungal prophylaxis with voriconazole vs. other antifungals in the first 100 days after allogeneic HSCT in patients aged <18 years between 2012 and 2018. The statistical analysis included univariate and multivariate analyses and determination of the cumulative incidence of invasive fungal infection by the Kaplan‒Meier method using STATA 14 statistical software. Results A total of 139 allogeneic HSCT were performed. The principal diagnosis was acute leukemia (63%). The 75% had haploidentical donors, and 50% used an antifungal in the month before transplantation. Voriconazole (69%) was the most frequently administered antifungal prophylaxis. The cumulative incidence of IFI was 5% (7 cases). Of the patients with IFIs, four began prophylaxis with voriconazole, one with caspofungin, and one with fluconazole. Additionally, six were possible cases, one was proven (Candida parapsilosis), and 1/7 died. Conclusion There were no differences in the incidence of IFI between patients who received prophylaxis with voriconazole and other antifungal agents.