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- 저자 : An T. T. Vo (검색결과 52 건)
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Phuong T. Ho(Phuong T. Ho ),Hee-Seong Byun(Hee-Seong Byun),Thuy T. B. Vo(Thuy T. B. Vo ),Aamir Lal(Aamir Lal ),Sukchan Lee(Sukchan Lee),Eui-Joon Kil(Eui-Joon Kil) 한국식물병리학회 2023 Plant Pathology Journal Vol.39 No.3
Sweet potato symptomless virus 1 (SPSMV-1) is a single-stranded circular DNA virus, belonging to the genus Mastrevirus (family Geminiviridae) that was first identified on sweet potato plants in South Korea in 2012. Although SPSMV-1 does not induce distinct symptoms in sweet potato plants, its co-infection with different sweet potato viruses is highly prevalent, and thus threatens sweet potato production in South Ko-rea. In this study, the complete genome sequence of a Korean isolate of SPSMV-1 was obtained by Sanger sequencing of polymerase chain reaction (PCR) am-plicons from sweet potato plants collected in the field (Suwon). An infectious clone of SPSMV-1 (1.1-mer) was constructed, cloned into the plant expression vec-tor pCAMBIA1303, and agro-inoculated into Nicotiana benthamiana using three Agrobacterium tumefaciens strains (GV3101, LBA4404, and EHA105). Although no visual differences were observed between the mock and infected groups, SPSMV-1 accumulation was detected in the roots, stems, and newly produced leaves through PCR. The A. tumefaciens strain LBA4404 was the most effective at transferring the SPSMV-1 genome to N. benthamiana. We confirmed the viral replication in N. benthamiana samples through strand-specific amplifi-cation using virion-sense- and complementary-sense-specific primer sets.
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Vo, Q.H.,Nguyen, P.H.,Zhao, B.T.,Ali, M.Y.,Choi, J.S.,Min, B.S.,Nguyen, T.H.,Woo, M.H. Elsevier 2015 Fitoterapia Vol.103 No.-
Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity. The bioactivity-guided isolation led to the separation of two new compounds, (+/-)-tradescantin (13) and tradescantoside (16), along with fourteen known compounds (1-12, 14, and 15) from the aerial parts of Tradescantia spathacea Sw. (Commelinaceae). Their chemical structures were elucidated by spectroscopic methods as well as by comparing with those reported in the literature. The isolated compounds (1-16) were then examined for their inhibitory activity toward PTP1B. The results indicated that compounds 2, 6, 8, and 12 possessed potent inhibition with IC<SUB>50</SUB> values of 7.82+/-0.79, 6.80+/-0.89, 4.55+/-0.92, and 6.38+/-0.14μM, respectively. Kinetic study of compounds 2, 6, 8, 12, 13, and 16 was conducted and the structure-activity relationships of the isolated compounds (1-16) were also discussed herein. To the best of our knowledge, all the isolates were separated for the first time from this plant.
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Vo, T.S.,Surabhi, S.,Luong, C.H.,Yoon, S.G.,Lee, K.D.,Park, B.G.,Jeong, J.R. Elsevier 2015 CURRENT APPLIED PHYSICS Vol.15 No.7
In this study, we have systematically investigated a magnetic resonance absorption and tunability of absorption wavelength in isolated metal-insulator-metal (MIM) nanodot arrays with transmission geometry. The elemental electromagnetic resonances and their hybridizations are studied using 3-dimensional finite-difference time-domain (FDTD) calculation and resonance properties including the resonance peak tunability, magnetic permeability and quality (Q) factor are characterized with respect to the coupling strength. We have found the existence of electric and magnetic resonance mode in the MIM (Au/MgF<SUB>2</SUB>/Au) structure and the magnetic resonance has larger wavelength tunability than the electric resonance. The absorption cross section calculation revealed that absorption is the dominant extinction process at the magnetic resonance only. Magnetic permeability (μ) calculations for the various MIM parameters showed the maximum value of the imaginary part of μ is 16.1 with Q factor of 9.2 when the size of nanodot is 200 nm and the inter-dot distance is 300 nm. The presented calculations can be used to tune the response of the magnetic resonance absorption with a variable resonance wavelength and Q factor by using the simple MIM structures with transmission geometry.
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An analysis on the severe accident progression with operator recovery actions
Vo, T.H.,Song, J.H.,Kim, T.W.,Kim, D.H. North-Holland Pub. Co 2014 Nuclear engineering and design Vol.280 No.-
Analyses on the severe accident progressions for the station blackout (SBO) accident and small break LOCA (SBLOCA) initiated severe accident were performed for APR1400 by using MELCOR computer code. Operator recovery actions for decay heat removal and inventory make up using a depressurization system and safety injection pump were simulated in parallel with a simulation of the severe accident progression. Sensitivity studies on the operator actions were performed to investigate the changes in the timing of the reactor vessel failure and to determine the time allowed for the operator to prevent reactor vessel failure. Sensitivity analyses on the effect of major modeling parameters were performed additionally to quantify the uncertainties in timing. It is found that the operator has about 2h for the recovery actions after the indication of core damage by the signal of core exit thermocouple (CET) for the SBLOCA initiated severe accident, while the operator has to take immediate actions after the indication of core damage by CET for the SBO accident.
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Vo, T.T.,Lee, C.,Han, S.I.,Kim, J.Y.,Kim, S.,Choi, Y.E. Elsevier Applied Science 2016 Bioresource technology Vol.220 No.-
In this study, we explored the effects of ACC on other stages of H. pluvialis. Interestingly, even though ACC displayed a dose-dependent effect on astaxanthin production, it is evident that astaxanthin production could be facilitated whenever the cells were treated at the early red stage. The transcriptional levels of BKT, CHY, SOD, and CAT genes supported enhanced astaxanthin biosynthesis upon ACC treatment at the early red stage. The combinatorial synergistic effect of ACC and light intensity was also confirmed. Finally, two-step application of ACC at the vegetative phase to increase biomass production and at the early-red stage to promote astaxanthin biosynthesis was proposed to maximize the efficiency of ACC treatment.
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Vo, Thuy T B,Jeung, Eui-Bae Academic Press 2009 TOXICOLOGICAL SCIENCES Vol.112 No.1
<P>In the present study, calbindin-D9k (CaBP-9k), a potent biomarker for screening estrogen-like environmental chemicals in vivo and in vitro, was adopted to examine the potential estrogen-like property of the following parabens: propyl-, isopropyl-, butyl-, and isobutylparaben. Immature female rats were administered for 3 days from postnatal day 14 to 16 with 17alpha-ethinylestradiol (EE, 1 mg/kg body weight [BW]/day) or parabens (62.5, 250, and 1000 mg/kg BW/day). In uterotrophic assays, significantly increased uterus weights were detected in the EE-treated group and in the groups treated with the highest dose of isopropyl-, butyl-, and isobutylparaben. In addition, these parabens induced uterine CaBP-9k messenger RNA (mRNA) and protein levels, whereas cotreatment of parabens and fulvestrant, a pure estrogen receptor (ER) antagonist, completely reversed the paraben-induced gene expression and increased uterine weights. To investigate the ER-mediated mechanism(s) by which parabens exert their effects, the expression level of ER-alpha and progesterone receptor (PR) was analyzed. Exposure to EE or parabens caused a dramatic decrease in expression of both ER-alpha mRNA and protein levels, whereas cotreatment with fulvestrant reversed these effects. These data showed the difference of CaBP-9k and ER-alpha expression, suggesting that CaBP-9k may not express via ER-alpha pathway. In the effect of parabens on CaBP-9k expression through PR mediation, a significantly increased expression of uterine PR gene, a well-known ER-regulating gene, at both transcriptional and translational levels was indicated in the highest dose of isopropyl- and butylparaben. These parabens-induced PR gene expression was completely blocked by fulvestrant. This result indicates that CaBP-9k expression may involve with PR mediates in the estrogenic effect of paraben in immature rat uteri. Taken together, parabens exhibited an estrogen-like property in vivo, which may be mediated by a PR and/or ER-alpha signaling pathway. In addition, our results expanded the current understanding of the potential adverse effects of parabens associated with their estrogen-like activities. Further investigation is needed to elucidate in greater detail the adverse effects of parabens in humans and wildlife.</P>
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VO, Thuy T. B.,JUNG, Eui-Man,DANG, Vu Hoang,JUNG, Kikyung,BAEK, Jounghee,CHOI, Kyung-Chul,JEUNG, Eui-Bae Society for Reproduction and Development 2009 Journal of Reproduction and Development Vol.55 No.4
<P>Endocrine disruptors (EDs) with androgenic and anti-androgenic effects may alter reproductive function by binding to androgenic receptors (AR) and inducing or modulating AR-dependent responses in the male reproductive system. However, the molecular mechanism(s) underlying these events remains unclear. In the present study, pregnant Sprague Dawley (SD) rats were treated with testosterone propionate (TP), flutamide (Flu) and di-(2-ethylhexyl) phthalate (DEHP) from gestation days (GD) 11 to 21. Interestingly, maternal exposure to Flu or DEHP caused fluctuations in the neonatal levels of serum testosterone (T) and luteinizing hormone (LH). Serum testosterone and LH were upregulated by Flu, but these hormones were down-regulated by DEHP. The anogenital distances (AGD) of male newborns were determined at post-neonatal days (PND) 1, 21 and 63. Male rats treated prenatally with DEHP (100 mg/kg mother's body weight) or Flu showed an AGD shorter than that of control rats. At PND 63, sperm concentration, viability and motility were reduced in the maternal DEHP and Flu-treated groups. The numbers of seminiferous tubules were reduced in the Flu and DEHP-treated offspring when compared with the vehicle- and TP-treated groups, and the tubules of the testes at PND 63 were disrupted by a high dose of Flu. In addition, we found differential gene expression patterns by microarray analysis following ED exposure, particularly in sex determination-related genes. Although Flu and DEHP are considered to be identical with regard to their anti-androgenic effects, their effects on developing male reproductive organs were distinct, suggesting that Flu competes with endogenous T, while DEHP influences a different step in androgenesis.</P>
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Vo, V. T. A.,Choi, J.-W.,Phan, A. N. H.,Hua, T. N. M.,Kim, M.-K.,Kang, B. H.,Jung, S.-H.,Yong, S.-J.,Jeong, Y. Potamitis Press 2018 Anticancer research Vol.38 No.4
<P>Background/Aim: Cancer cells are distinct in terms of glutamine dependence. Here we investigated the different susceptibility of glutamine-independent and glutamine-dependent non-small cell lung cancer (NSCLC) to treatment with tumor necrosis factor receptor-associated protein 1 (TRAP1) inhibitor gamitrinib-triphenylphosphonium (G-TPP). Materials and Methods: Cell viability and proliferation under glutamine deprivation and G-TPP treatment were determined by the MTT and colony-formation assays. Protein and mRNA expression were determined by western blot and quantitative polymerase chain reaction. Colorimetric-based assay was performed to check for glutamine synthetase (GS) activity. Results: NSCLC cells showed diverse adaptation under glutamine-depleted condition and were categorized into glutamine-independent and glutamine-dependent cells. Treatment with G-TPP particularly increased GS activity and induced cell death due to energy shortage indicated by phosphorylated AMP-activated protein kinase (AMPK) in glutamine-dependent cells. Conclusion: This finding provides better understanding of TRAP1-mediated glutamine metabolism through GS activity, and evidence that TRAP1 could be a promising therapeutic target for glutamine-addicted cancer.</P>
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