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RISS 인기검색어
- 검색키워드
- 저자 : Amteshwar S. Jaggi (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Gautamjeet S Mangat,Amteshwar S Jaggi,Nirmal Singh 대한생리학회-대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.3
The present study was designed to investigate the efficacy of selective ETA receptor antagonist, ambrisentan on hyperhomocysteinemia-induced experimental vascular dementia. L-methionine was administered for 8 weeks to induce hyperhomocysteinemia and associated vascular dementia in male rats. Ambrisentan was administered to L-methionine-treated effect rats for 4 weeks (starting from 5<sup>th</sup> to 8<sup>th</sup> week of L-methionine treatment). On 52<sup>nd</sup> day onward, the animals were exposed to the Morris water maze (MWM) for testing their learning and memory abilities. Vascular endothelial function, serum nitrite/nitrate levels, brain thiobarbituric acid reactive species (TBARS), brain reduced gluta-thione (GSH) levels, and brain acetylcholinesterase (AChE) activity were also measured. L-methionine-treated animals showed significant learning and memory impairment, endothelial dysfunction, decrease in/serum nitrite/nitrate and brain GSH levels along with an increase in brain TBARS levels and AChE activity. Ambrisentan significantly improved hyperhomocysteinemia-induced impairment of learning, memory, endothelial dysfunction, and changes in various biochemical parameters. These effects were comparable to that of donepezil serving as positive control. It is concluded that ambrisentan, a selective ET<sub>A</sub> receptor antagonist may be considered as a potential pharmacological agent for the management of hyperhomocysteinemia-induced vascular dementia.
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Gautamjeet S Mangat,Amteshwar S. Jaggi,Nirmal Singh 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.3
The present study was designed to investigate the efficacy of selective ETA receptor antagonist, ambrisentanon hyperhomocysteinemia-induced experimental vascular dementia. L-methionine was administeredfor 8 weeks to induce hyperhomocysteinemia and associated vascular dementia in male rats. Ambrisentan was administered to L-methionine-treated effect rats for 4 weeks (starting from 5th to8th week of L-methionine treatment). On 52nd day onward, the animals were exposed to the Morriswater maze (MWM) for testing their learning and memory abilities. Vascular endothelial function,serum nitrite/nitrate levels, brain thiobarbituric acid reactive species (TBARS), brain reduced glutathione(GSH) levels, and brain acetylcholinesterase (AChE) activity were also measured. L-methionine-treated animals showed significant learning and memory impairment, endothelial dysfunction,decrease in/serum nitrite/nitrate and brain GSH levels along with an increase in brain TBARS levelsand AChE activity. Ambrisentan significantly improved hyperhomocysteinemia-induced impairment oflearning, memory, endothelial dysfunction, and changes in various biochemical parameters. Theseeffects were comparable to that of donepezil serving as positive control. It is concluded that ambrisentan,a selective ETA receptor antagonist may be considered as a potential pharmacological agentfor the management of hyperhomocysteinemia-induced vascular dementia.
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Mangat, Gautamjeet S.,Jaggi, Amteshwar S.,Singh, Nirmal The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.3
The present study was designed to investigate the efficacy of selective $ET_A$ receptor antagonist, ambrisentan on hyperhomocysteinemia-induced experimental vascular dementia. L-methionine was administered for 8 weeks to induce hyperhomocysteinemia and associated vascular dementia in male rats. Ambrisentan was administered to L-methionine-treated effect rats for 4 weeks (starting from $5^{th}$ to $8^{th}$ week of L-methionine treatment). On $52^{nd}$ day onward, the animals were exposed to the Morris water maze (MWM) for testing their learning and memory abilities. Vascular endothelial function, serum nitrite/nitrate levels, brain thiobarbituric acid reactive species (TBARS), brain reduced glutathione (GSH) levels, and brain acetylcholinesterase (AChE) activity were also measured. L-methionine-treated animals showed significant learning and memory impairment, endothelial dysfunction, decrease in/serum nitrite/nitrate and brain GSH levels along with an increase in brain TBARS levels and AChE activity. Ambrisentan significantly improved hyperhomocysteinemia-induced impairment of learning, memory, endothelial dysfunction, and changes in various biochemical parameters. These effects were comparable to that of donepezil serving as positive control. It is concluded that ambrisentan, a selective $ET_A$ receptor antagonist may be considered as a potential pharmacological agent for the management of hyperhomocysteinemia-induced vascular dementia.
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Rupinder K. Sodhi,Manjeet Singh,Amteshwar S. Jaggi,Nirmal Singh 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.7
The present study was designed to investigate the cardio-protective effect of Ac-LEDH-cmk a selective caspase-9 inhibitor and 5-aminoisoquinolinone a selective Poly (ADP-ribose) polymerase inhibitor on ischemia and reperfusion induced apoptotic and necrotic cell death in rats. Isolated rat hearts were exposed to 30 minutes of global ischemia followed by 120 minutes of reperfusion using Langendorff’s apparatus. Myocardial injury was assessed in the terms of infarct size, release of lactate dehydrogenase, creatine kinase enzymes and apoptotic index was assessed by DNA smearing on agarose gel electrophoresis. Pretreatments with specific inhibitor of caspase-9, Ac-LEHD-cmk (0.07 μM and 0.105 μM), and inhibitor of PARP, 5-aminoisoquinolinone (5 μM and 7.5 μM), significantly attenuated I/R induced increase in infarct size, release of lactate dehydrogenase and creatine kinase in the coronary effluent, and apoptotic index. Therefore, it may be concluded that inhibition of caspase-9 and PARP prevent ischemia and reperfusion-induced activation of apoptotic cascade and necrosis in rat myocardium.
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