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RISS 인기검색어
- 검색키워드
- 저자 : Alisha Palikhe (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Anti-inflammatory Effects of Flavonoids on TNBS-induced Colitis of Rats
주민재,김한상,Alisha Palikhe,Tin Sandar Zaw,정지훈,손의동,권태훈 대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.1
It has been shown that the extracts including eupatilin and quercetin-3-β -D-glucuronopyranosidehad mucoprotective effects on the esophagus and stomach through their antioxidant activities. Thisstudy was designed to investigate the anti-inflammatory effect of these flavonoid compounds in ananimal model of inflammatory bowel disease induced by 2,4,6-trinitrobenzene sulfonic acid. Experimental colitis was induced by intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid. Extracts including eupatilin or quercetin-3-β -D-glucuronopyranoside were orally administered toanimals 48, 24, and 1 h prior to the induction of colitis and then again 24 h later. The animals weresacrificed 48 h after by 2,4,6-trinitrobenzene sulfonic acid treatment and the macroscopic appearanceof the colonic lesions was scored in a blinded manner on a scale of 1 to 10. The inflammatory responseto colitis induction was assessed by measuring myeloperoxidase activity, nitric oxide production, tumornecrosis factor-α expression, total glutathione levels, and malondialdehyde concentrations in the colon. The results indicated that extracts including eupatilin and extracts including quercetin-3-β-D-glucuronopyranosidedose-dependently improved the morphology of the lesions induced by 2,4,6-trinitrobenzenesulfonic acid and reduced the ulcer index accordingly. In addition, rats receiving extractsincluding eupatilin and extracts including quercetin-3-β -D-glucuronopyranoside showed significantlydecreased levels of mucosal myeloperoxidase activity, nitric oxide production, tumor necrosis factor-αexpression, and malondialdehyde levels, and increased total glutathione levels. Extracts includingeupatilin and extracts including quercetin-3-β -D-glucuronopyranoside ameliorated the inflammatoryresponse and colonic injury in acute colitis by decreasing oxidative stress and neutrophil activation. Extracts including eupatilin and extracts including quercetin-3-β -D-glucuronopyranoside may inhibitacute colitis.
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Anti-inflammatory Effects of Flavonoids on TNBS-induced Colitis of Rats
Joo, Minjae,Kim, Han Sang,Kwon, Tae Hoon,Palikhe, Alisha,Zaw, Tin Sandar,Jeong, Ji Hoon,Sohn, Uy Dong The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.1
It has been shown that the extracts including eupatilin and quercetin-3-${\beta}$-D-glucuronopyranoside had mucoprotective effects on the esophagus and stomach through their antioxidant activities. This study was designed to investigate the anti-inflammatory effect of these flavonoid compounds in an animal model of inflammatory bowel disease induced by 2,4,6-trinitrobenzene sulfonic acid. Experimental colitis was induced by intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid. Extracts including eupatilin or quercetin-3-${\beta}$-D-glucuronopyranoside were orally administered to animals 48, 24, and 1 h prior to the induction of colitis and then again 24 h later. The animals were sacrificed 48 h after by 2,4,6-trinitrobenzene sulfonic acid treatment and the macroscopic appearance of the colonic lesions was scored in a blinded manner on a scale of 1 to 10. The inflammatory response to colitis induction was assessed by measuring myeloperoxidase activity, nitric oxide production, tumor necrosis factor-${\alpha}$ expression, total glutathione levels, and malondialdehyde concentrations in the colon. The results indicated that extracts including eupatilin and extracts including quercetin-3-${\beta}$-D-glucuronopyranoside dose-dependently improved the morphology of the lesions induced by 2,4,6-trinitrobenzene sulfonic acid and reduced the ulcer index accordingly. In addition, rats receiving extracts including eupatilin and extracts including quercetin-3-${\beta}$-D-glucuronopyranoside showed significantly decreased levels of mucosal myeloperoxidase activity, nitric oxide production, tumor necrosis factor-${\alpha}$ expression, and malondialdehyde levels, and increased total glutathione levels. Extracts including eupatilin and extracts including quercetin-3-${\beta}$-D-glucuronopyranoside ameliorated the inflammatory response and colonic injury in acute colitis by decreasing oxidative stress and neutrophil activation. Extracts including eupatilin and extracts including quercetin-3-${\beta}$-D-glucuronopyranoside may inhibit acute colitis.
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