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- 저자 : Alfred O. Ankrah (검색결과 1 건)
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Alfred O. Ankrah,Andor W. J. M. Glaudemans,Hans C. Klein,Rudi A. J. O. Dierckx,Mike Sathekge 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.2
Human immune deficiency virus (HIV) is a leadingcause of death. It attacks the immune system, thereby renderingthe infected host susceptible to many HIV-associated infections,malignancies and neurocognitive disorders. The alteredimmune system affects the way the human host respondsto disease, resulting in atypical presentation of these disorders. This presents a diagnostic challenge and the clinician must useall diagnostic avenues available to diagnose and manage theseconditions. The advent of highly active antiretroviral therapy(HAART) has markedly reduced the mortality associated withHIVinfection but has also brought in its wake problems associatedwith adverse effects or drug interaction and may evenmodulate some of the HIV-associated disorders to the detrimentof the infected human host. Nuclear medicine techniquesallow non-invasive visualisation of tissues in the body. Byusing this principle, pathophysiology in the body can betargeted and the treatment of diseases can be monitored. Being a functional imaging modality, it is able to detect diseasesat the molecular level, and thus it has increased ourunderstanding of the immunological changes in the infectedhost at different stages of the HIV infection. It also detectspathological changes much earlier than conventional imagingbased on anatomical changes. This is important in theimmunocompromised host as in some of the associated disordersa delay in diagnosis may have dire consequences. Nuclear medicine has played a huge role in the managementof many HIV-associated disorders in the past and continues tohelp in the diagnosis, prognosis, staging, monitoring andassessing the response to treatment of many HIV-associateddisorders. As our understanding of the molecular basis of diseaseincreases nuclear medicine is poised to play an evengreater role. In this review we highlight the functional basisof the clinicopathological correlation of HIV from a metabolicview and discuss how the use of nuclear medicine techniques,with particular emphasis of F-18 fluorodeoxyglucose, mayhave impact in the setting of HIV. We also provide an overviewof the role of nuclear medicine techniques in the managementof HIV-associated disorders.
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