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The Concept of One Health for Allergic Diseases and Asthma
Agache Ioana,Laculiceanu Alexandru,Spanu Daniela,Grigorescu Dan 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.3
The worldwide prevalence of allergic disease is rising as a result of complex gene-environment interactions that shape the immune system and host response. Climate change and loss of biodiversity are existential threats to humans, animals, plants, and ecosystems. While there is significant progress in the development of targeted therapeutic options to treat allergies and asthma, these approaches are inadequate to meet the challenges faced by climate change. The exposomic approach is needed with the recognition of the bidirectional effect between human beings and the environment. All stakeholders need to work together toward mitigating the effects of climate change and promoting a One Health concept in order to decrease the burden of asthma and allergy and to improve immune health. Healthcare professionals should strive to incorporate One Health counseling, environmental health precepts, and advocacy into their practice.
Critical Points on the Use of Biologicals in Allergic Diseases and Asthma
Ioana Agache,Catalina Cojanu,Alexandru Laculiceanu,Liliana Rogozea 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.1
Improved understanding of the contribution of immune-inflammatory mechanisms in allergic diseases and asthma has encouraged development of biologicals and small molecules specifically targeting the innate and adaptive immune response. There are several critical points impacting the efficacy of this stratified approach, from the complexity of disease endotypes to the effectiveness in real-world settings. We discuss here how these barriers can be overcome to facilitate the development of implementation science for allergic diseases and asthma.