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Al-Fatlawi, Atheer Abbas,Al-Fatlawi, Anees Abbas,Irshad, Md.,Zafaryab, Md.,Alam Rizvi, M. Moshahid,Ahmad, Ayaz Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Phytic acid (PA) has been reported to have positive nutritional benefits and prevent cancer formation. This study investigated the anticancer activity of rice bran PA against hepatocellular carcinoma (HepG2) cells. Cytotoxicty of PA (0.5 to 4mM) was examined by MTT and LDH assays after 24 and 48h treatment. Apoptotic activity was evaluated by expression analysis of apoptosis-regulatory genes [i.e. p53, Bcl-2, Bax, Caspase-3 and -9] by reverse transcriptase-PCR and DNA fragmentation assay. The results showed antioxidant activity of PA in Fe3+ reducing power assay ($p{\leq}0.03$). PA inhibited the growth of HepG2 cells in a concentration dependent manner ($p{\leq}0.04$). After 48h treatment, cell viability was recorded 84.7, 74.4, 65.6, 49.6, 36.0 and 23.8% in MTT assay and 92.6, 77.0%, 66.8%, 51.2, 40.3 and 32.3% in LDH assay at concentrations of 1, 1.5, 2.0, 2.5, 3.0, and 3.5mM, respectively. Hence, treatment of PA for 24h, recorded viability of cells 93.5, 88.6, 55.5, 34.6 and 24.4% in MTT assay and 94.2, 86.1%, 59.7%, 42.3 and 31.6%, in LDH assay at concentrations of 1, 2.2, 3.0, 3.6 and 4.0mM, respectively. PA treated HepG2 cells showed up-regulation of p53, Bax, Caspase-3 and -9, and down-regulation of Bcl-2 gene ($p{\leq}0.01$). At the $IC_{50}$ (2.49mM) of PA, the p53, Bax, Caspase-3 and-9 genes were up-regulated by 6.03, 7.37, 19.7 and 14.5 fold respectively. Also, the fragmented genomic DNA in PA treated cells provided evidence of apoptosis. Our study confirmed the biological activity of PA and demonstrated growth inhibition and induction of apoptosis in HepG2 cells with modulation of the expression of apoptosis-regulatory genes.
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Optimal design of a lightweight composite sandwich plate used for airplane containers
Alaa Al-Fatlawi,Károly Jármai,György Kovács 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.78 No.5
Composite material-due to low density-causes weight savings, which results in lower fuel consumption of transport vehicles. The aim of the research was to change the existing base-plate of the aluminum airplane container with the composite sandwich plate in order to reduce the weight of the containers of cargo aircrafts. The newly constructed sandwich plate consists of aluminum honeycomb core and composite face-sheets. The face-sheets consist of glass or carbon or hybrid fiber layers. The orientations of the fibers in the face-sheets were 0°, 90° and ±45°. Multi-objective optimization method was elaborated for the newly constructed sandwich plates. Based on the design aim, the importance of the objective functions (weight and cost of sandwich plates) was the same (50%). During the optimization nine design constraints were considered: stiffness, deflection, facing stress, core shear stress, skin stress, plate buckling, shear crimping, skin wrinkling, intracell buckling. The design variables were core thickness and number of layers of the face-sheets. During the optimization both the Weighted Normalized Method of the Excel Solver and the Genetic Algorithm Solver of Matlab software were applied. The mechanical properties of composite face-sheets were calculated by Laminator software according to the Classical Lamination Plate Theory and Tsai-Hill failure criteria. The main added-value of the study is that the multi-objective optimization method was elaborated for the newly constructed sandwich structures. It was confirmed that the optimal new composite sandwich construction-due to weight savings and lower fuel consumption of cargo aircrafts - is more advantageous than conventional all-aluminum container.
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HAMEEDI, Karrar Saleem,AL-FATLAWI, Qayssar Ali,ALI, Maher Naji,ALMAGTOME, Akeel Hamza Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3
This paper explores the effect of IFRS on the financial performance of Iraqi commercial banks. It also investigates the value significance of financial performance statements using the Ohlson model, which has been used for the stock value relevance test in a number of studies. Using a sample of 66 listed banks on the Iraq Stock Exchange over three years of IFRS pre-adoption (2011-2013) and three years of IFRS post-adoption (2016-2018), we find financial performance components EPS and BVS value relevant to the stock returns. The findings also indicate that the implementation of IFRS has a major positive effect on the value relevance of the BVS, while the adoption of IFRS does not have a significant impact on the value relevance of the EPS reported by Iraqi banks. Our results indicate that the market value of the bank rises dramatically with enhanced financial performance reporting. In addition, the implementation of IFRS has a major effect on the financial performance measures and the value relevance of financial reporting in the Iraqi banking sector. This paper adds to previous value relevance literature and IFRS by throwing light on the banking sector in a developing country that has recently moved from applying local accounting standards to IFRS.
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Kamesh Bodduru,Lavish Kumar Singh,Mesfn Kebede Kassa,Alaa Al‑Fatlawi,Ananda Babu Arumugam 한국섬유공학회 2023 Fibers and polymers Vol.24 No.10
In the present work, the bending behavior of honeycomb-cored multi-walled carbon nanotube (MWCNT) reinforced sandwich composite plate was investigated using an in-house finite element model based on higher-order shear deformation theory and commercial Digimat-HC software. Along with various parametric studies, the influence of the weight fraction of MWCNTs, cell size thickness and height of the core on bending behavior, face sheet bending stress and core shear ultimate strength were numerically investigated. Results showed that the central deflection values obtained via the three-point bending test were in good agreement with the developed FEM model and Digimat-HC software. The deviation of experimental values from the developed FEM model varied in the range of 2.73–3.98%, whereas, from the Digimat-HC software, the experimental values deviated in the range of 2.32–4.88%. Irrespective of the test temperature, the CNT-reinforced honeycomb sandwich composite exhibited far superior bending behavior as compared to the neat epoxy composite; displaying 8%, 21% and 12% higher load-bearing capacity at 30 °C, 60 °C and 90 °C, respectively. The MWCNT reinforced honeycomb core sandwich composite displayed the best amalgamation of core shear strength and face sheet bending stress, when the core height, Ch = 5. The developed techniques can be used to determine the dimensions of honeycomb cored sandwich structure, as required for different applications.
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