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- 저자 : Agnieszka Loboda (검색결과 3 건)
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HIF-1 and HIF-2 Transcription Factors - Similar but Not Identical
Loboda, Agnieszka,Jozkowicz, Alicja,Dulak, Jozef Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.5
Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF-1${\alpha}$, but also more cell-specific HIF-2${\alpha}$, is an important regulator of the hypoxia response. Although both ${\alpha}$ subunits are highly conservative at protein level, share similar domain structure, heterodimerize with HIF-1${\beta}$, and bind to the same DNA sequence called hypoxia responsive element (HRE), their effect on the expression of some genes may vary. In this review we stressed the differences between the isoforms, their structure and expression pattern. Moreover, we described diversity of coactivators and proteins which interact with HIFs, and which are responsible for the specificity of their action. Finally, recent data showing link between HIFs and specific microRNA have been presented.
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Targeting Nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives
( Agnieszka Loboda ),( Ewa Rojczyk Golebiewska ),( Barbara Bednarczyk Cwynar ),( Lucjusz Zaprutko ),( Alicja Jozkowicz ),( Jozef Dulak ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.6
Chemoprevention represents a strategy designed to protect cells or tissues against various carcinogens and carcinogenic me-tabolites derived from exogenous or endogenous sources. Recent studies indicate that plant-derived triterpenoids, like oleanolic acid, may exert cytoprotective functions via regulation of the activity of different transcription factors. The chemopreventive effects may be mediated through induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor. Activation of Nrf2 by triterpenoids induces the expression of phase 2 detoxifying and antioxidant enzymes such as NAD(P)H quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) - proteins which can protect cells or tissues against various toxic metabolites. On the other hand, inhibition of other transcription factors, like NF-κB leads to the decrease in the pro-inflammatory gene expression. Moreover, the modulation of microRNAs activity may constitute a new mechanism responsible for valuable effects of triterpenoids. Recently, based on the structure of naturally occurring triterpenoids and with involvement of bioinformatics and computational chemistry, many synthetic analogs with improved biological properties have been obtained. Data from in vitro and in vivo experi-ments strongly suggest synthetic derivatives as promising candidates in the chemopreventive and chemotherapeutic strategies.
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HIF-1 and HIF-2 Transcription Factors - Similar but Not Identical
Agnieszka Loboda,Alicja Jozkowicz,Jozef Dulak 한국분자세포생물학회 2010 Molecules and cells Vol.29 No.5
Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF-1α, but also more cell-specific HIF-2α, is an important regulator of the hypoxia response. Although both α subunits are highly conservative at protein level, share similar domain structure, heterodimerize with HIF-1β, and bind to the same DNA sequence called hypoxia responsive element (HRE), their effect on the expression of some genes may vary. In this review we stressed the differences between the isoforms, their structure and expression pattern. Moreover, we described diversity of coactivators and proteins which interact with HIFs, and which are responsible for the specificity of their action. Finally, recent data showing link between HIFs and specific microRNA have been presented.
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