Orthogonally blocked mixture component–amount designs via projections of F-squares

M. L. AGGARWAL,Poonam Singh,Vandana Sarin,Bushra Husain 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.1

Orthogonal block designs for Scheffé’s quadratic model have been considered previously by Draper et al. (1993), John (1984), Lewis et al. (1994) and Prescott, Draper, Dean, and Lewis (1993). Prescott and Draper (2004) obtained mixture component–amount designs via projections of standard mixture designs, viz., the simplex-lattice, the simplex-centroid and the orthogonally blocked mixture designs based on latin squares. Aggarwal, Singh,Sarin, and Husain (2009) considered the case of components assuming equal volume fractions and obtained mixture designs in orthogonal blocks using F-squares. In this paper,we construct orthogonal blocks of two and three mixture component–amount blends by projecting the class of four component mixture designs presented by Aggarwal et al. (2009).

Reconstruction of a genome-scale metabolic network of <i>Rhodococcus erythropolis</i> for desulfurization studies

Aggarwal, Shilpi,Karimi, I. A.,Lee, Dong Yup Royal Society of Chemistry 2011 Molecular bioSystems Vol.7 No.11

<P>The remarkable catabolic diversity of <I>Rhodococcus erythropolis</I> makes it an interesting organism for bioremediation and fuel desulfurization. However, a model that can describe and explain the combined influence of various intracellular metabolic activities on its desulfurizing capabilities is missing from the literature. Such a model can greatly aid the development of <I>R. erythropolis</I> as an effective desulfurizing biocatalyst. This work reports the reconstruction of the first genome-scale metabolic model for <I>R. erythropolis</I> using the available genomic, experimental, and biochemical information. We have validated our <I>in silico</I> model by successfully predicting cell growth results and explaining several experimental observations in the literature on biodesulfurization using dibenzothiophene. We report several <I>in silico</I> experiments and flux balance analyses to propose minimal media, determine gene and reaction essentiality, and compare effectiveness of carbon, nitrogen, and sulfur sources. We demonstrate the usefulness of our model by studying a few <I>in silico</I> mutants of <I>R</I>. <I>erythropolis</I> for improved biodesulfurization, and comparing the desulfurization abilities of <I>R. erythropolis</I> with an <I>in silico</I> mutant of <I>E. coli</I>.</P> <P>Graphic Abstract</P><P>This work reports the reconstruction of the first genome-scale metabolic model for <I>R. erythropolis</I> using the available genomic, experimental, and biochemical information. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1mb05201b'> </P>

An Investigation into the Impact on Voltage Sag due to Faults in Low Voltage Power Distribution Systems

Aggarwal R. K. The Korean Institute of Electrical Engineers 2005 KIEE International Transactions on Power Engineeri Vol.a5 No.2

Voltage sags are the most widespread quality issues affecting distribution systems. This paper describes in some detail the voltage sag characteristics due to different types and locations of fault in a practical low voltage power distribution system encountered in the UK. The results not only give utility engineers very useful information when identifying parts of the system most likely to pose problems for customer equipments, but also assist the facility personnel to make decisions on purchasing power quality mitigation equipment.

Real world adverse events of interspinous spacers using Manufacturer and User Facility Device Experience data

Aggarwal Nitish,Chow Robert 대한마취통증의학회 2021 Anesthesia and pain medicine Vol.16 No.2

Background: Lumbar spinal stenosis is a condition of progressive neurogenic claudication that can be managed with lumbar decompression surgery or less invasive interspinous process devices after failed conservative therapy. Popular interspinous process spacers include X-Stop, Vertiflex and Coflex, with X-Stop being taken off market due to its adverse events profile. Methods: A disproportionality analysis was conducted to determine whether a statistically significant signal exists in the three interspinous spacers and the reported adverse events using the Manufacturer and User Facility Device Experience (MAUDE) database maintained by the US Food and Drug Administration. Results: Statistically significant signals were found with each of the three interspinous spacer devices (Coflex, Vertiflex, and X-Stop) and each of the following adverse events: fracture, migration, and pain/worsening symptoms. Conclusions: Further studies such as randomized controlled trials are needed to validate the findings.

Effect of Compositional Parameters on the Characteristics of C-SiC-$B_4C$ Composites

Aggarwal, R.K.,Bhatia, G.B.,Saha, M.,Mishra, A. Korean Carbon Society 2004 Carbon Letters Vol.5 No.4

Carbon-ceramic composites refer to a special class of carbon based materials which cover the main drawbacks of carbon, particularly its proneness to air oxidation, while essentially retaining its outstanding properties. In the present paper, the authors report the results of a systematic study made towards the development of C-SiC-$B_4C$ composites, which involves the effects of compositional parameters, namely, carbon-to-ceramic and ceramic-to-ceramic ratios, on the oxidation behaviour as well as other characteristics of these composites. The C-SiC-$B_4C$ composites, heat-treated to $1400^{\circ}C$, have shown that their oxidation behaviour at temperatures of 800~$1200^{\circ}C$ depends jointly on the total ceramic content and the SiC : $B_4C$ ratio. Good compositions of C-SiC-$B_4C$ composites exhibiting zero weight loss in air at temperatures of 800~$1200^{\circ}C$ for periods of 4~9 h, have been identified. Composites with these compositions undergo a weight gain or a maximum weight loss of less than 3% during the establishment of a protective layer at the surface of carbon in a period of 1~6 h. Significant improvement in the strength of C-SiC-$B_4C$ composites has been observed which increases with an increase in the total ceramic content and also with an increase in the SiC : $B_4C$ ratio.

Comparison of anxiety and pain perceived with conventional and computerized local anesthesia delivery systems for different stages of anesthesia delivery in maxillary and mandibular nerve blocks

Aggarwal, Kamal,Lamba, Arundeep Kaur,Faraz, Farrukh,Tandon, Shruti,Makker, Kanika The Korean Dental Society of Anesthsiology 2018 Journal of Dental Anesthesia and Pain Medicine Vol.18 No.6

Background: Fear of local anesthesia (LA) is a significant impediment to dental care as many patients delay or avoid treatment to avert pain. Computer-controlled local anesthetic delivery system (CCLAD), with constant and controlled rate of flow, present a painless alternative. The present study aimed to compare anxiety and pain perceived with conventional and computerized systems, for different stages of anesthesia delivery when administering various nerve blocks. Methods: One hundred patients requiring bilateral LA participated in the study. One side was anesthetized using one system and the contralateral side was anesthetized using the other, in two separate appointments. Patients assigned anxiety scores on a 5-point scale and used the visual analogue scale (VAS) for pain determination at needle insertion, during delivery of anesthetic solution, immediately after injection, and at the end of the periodontal procedure. Each patient's preference for the delivery system of future injections was also recorded. Results: Patients reported significantly lower anxiety levels with CCLAD compared to the syringe. Significantly lower mean VAS scores for anesthesia deposition, pain immediately after, and at the end of the periodontal procedure were also noted. However, pain at needle insertion was comparable between the two systems, with no statistical significance. Overall, 64.4% patients preferred CCLAD for future anesthesia. Conclusion: Lower pain perceived with CCLAD and higher preference for the system suggest that CCLAD should replace conventional syringes to allow pain-free dental treatment.

2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis : An International Myositis Assessment and Clinical Studies Group/Paediatric Rh

Aggarwal, Rohit,Rider, Lisa G,Ruperto, Nicolino,Bayat, Nastaran,Erman, Brian,Feldman, Brian M,Oddis, Chester V,Amato, Anthony A,Chinoy, Hector,Cooper, Robert G,Dastmalchi, Maryam,Fiorentino, David,Ise H. K. Lewis 2017 Annals of the rheumatic diseases Vol.76 No.5

<P>To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions were evaluated on patient profiles using expert consensus (gold standard) and were validated using data from a clinical trial. The nominal group technique was used to reach consensus. Consensus was reached for a conjoint analysis-based continuous model using absolute per cent change in core set measures (physician, patient, and extramuscular global activity, muscle strength, Health Assessment Questionnaire, and muscle enzyme levels). A total improvement score (range 0-100), determined by summing scores for each core set measure, was based on improvement in and relative weight of each core set measure. Thresholds for minimal, moderate, and major improvement were >= 20, >= 40, and >= 60 points in the total improvement score. The same criteria were chosen for juvenile DM, with different improvement thresholds. Sensitivity and specificity in DM/ PM patient cohorts were 85% and 92%, 90% and 96%, and 92% and 98% for minimal, moderate, and major improvement, respectively. Definitions were validated in the clinical trial analysis for differentiating the physician rating of improvement (p< 0.001). The response criteria for adult DM/ PM consisted of the conjoint analysis model based on absolute per cent change in 6 core set measures, with thresholds for minimal, moderate, and major improvement.</P>

TIGHT ASYMMETRIC ORTHOGONAL ARRAYS OF STRENGTH 2 USING FINITE PROJECTIVE GEOMETRY

Aggarwal M.L.,Deng Lih Yuan,Mazumder Mukta D. The Korean Statistical Society 2006 Journal of the Korean Statistical Society Vol.35 No.1

Wu et al. (1992) constructed some general classes of tight asymmetric orthogonal arrays of strength 2 using the method of grouping. Rains et al. (2002) obtained asymmetric orthogonal arrays of strength 2 using the concept of mixed spread in finite projective geometry. In this paper, we obtain some new tight asymmetric orthogonal arrays of strength 2 using the concept of mixed partition in finite projective geometry.

Introduction of the Indian Society for Mass Spectrometry (ISMAS) (http:// www.ismas.org)

Aggarwal, Suresh K. Korean Society for Mass Spectrometry 2012 Mass spectrometry letters Vol.3 No.1

Pulmonary and Cutaneous Evaporative Water Losses in Sahiwal and Sahiwal × Holstein Cattle During Solar Exposure

Aggarwal, Anjuli,Upadhyay, R.C. Asian Australasian Association of Animal Productio 1997 Animal Bioscience Vol.10 No.3

In order to assess the effect of solar exposure on pulmonary functions and evaporative losses from skin and pulmonary surfaces, in six healthy Sahiwal (S) and six Sahiwal ${\times}$ Holstein ($S{\times}H$) cattle were exposed to direct sun during summer. Breed differences were observed during exposure. Increase in sweating rate was higher in crossbreds (222%) than in Sahiwal (125%). Pre-exposure (ambient temperature, $32.6{\pm}0.85^\circ}C$, solar radiation, $0.9cal\;cm^{-2}min^{-1}$) evaporative loss from skin accounted for about 90% of the losses and remaining losses were contributed by pulmonary surfaces in Sahiwal. The contribution of evaporation through skin increased to 92% (ambient temperature $39.4{\pm}0.68^\circ}C$, solar radiation, $1.35cal\;cm^{-2}min^{-1}$). In crossbreds 80% of the evaporative losses were through skin before exposure which increased to 87% after exposure to solar radiations. Rectal temperature increase was higher in crossbreds ($1.5^{\circ}C$) than in Sahiwal ($0.8^{\circ}C$). With the increase in pulmonary evaporative losses, respiratory frequency increased to 2 fold in Sahiwal and pulmonary ventilation increased 1.6 times the resting value in Sahiwal due to solar exposure. In $S{\times}H$ crossbreds the respiratory frequency increased 3.5 times and pulmonary ventilation increased only to 1.8 times due to decrease in tidal volume. There was about 2 fold increase in alveolar ventilation in both the breeds, the increase in dead space ventilation was more in crossbreds than in Sahiwal. Behavioral symptoms exhibited by animals after exposure were profuse salivation, open mouth panting, tongue protrusion and general restlessness.