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Bjurberg, Maria,Abedinpour, Parisa,Brun, Eva,Baldetorp, Bo,Borgstrom, Per,Wennerberg, Johan,Kjellen, Elisabeth 대한핵의학회 2010 핵의학 분자영상 Vol.44 No.3
Purpose Early metabolic response with a decrease in glucose demand after cytotoxic treatment has been reported to precede tumor volume shrinkage. However, preclinical studies report of a very early rise in metabolism, a flare, following treatment. To elucidate these observations, we performed an experimental study on early metabolic response with sequential analysis of metabolic changes. Methods Three squamous cell carcinoma cell lines and one nontumorigenic cell line were exposed to cisplatin. The uptake of the fluorescent glucose analogue 2-NBDG was examined at days 1.6 using fluorescence microscopy. The relation between 2-NBDG-uptake and cell survival was evaluated. Results The tumor cells exhibited a high uptake of 2-NBDG, whereas the uptake in the nonmalignant cells was low. The more cisplatin sensitive cell lines exhibited a more pronounced metabolic flare than the less sensitive cell line. Conclusion A metabolic flare was a very early sign of treatment response and potentially it could be used as an early marker of treatment sensitivity.
Siyamak Safapour,Majid Mazhar,Saiedeh Abedinpour 한국섬유공학회 2023 Fibers and polymers Vol.24 No.9
Reseda luteola L., commonly known as weld, is an important source of yellow natural dye used for dyeing the wool textiles since ancient times. In this study, to develop the color shades of weld on wool textiles, single and binary combinations of eight metal mordants, i.e., Al, Fe, Cu, Co, Zn, Sn, Ni, and Cr were explored using the premordanting method. Depending on the type and nature of mordant in the mixture, substantial variations in the color shades, lightness, color strength, and fastness of the samples resulted. In addition to metal mordants that individually improved color strength, color fastness and produced various color shades, binary mordanting showed several novel features in terms of the development of new color shades, the synergistic effect of dye uptake (color strength), and color fastness, etc. Furthermore, several rare or unique shades of high-cost and toxic mordants, such as Cr, could be reproduced using alternative binary low-cost and non- or less toxic mordants, such as Fe and Cu.